生体機能評価研究チーム

生体まるごとを対象にした非侵襲的なin vivo のライヴイメージング技術は、疾患の早期発見，診断，そして治療薬の開発に欠かすことのできない重要なツールです。当チームはライヴイメージング技術により生体内における分子の挙動を解析し、その分子の持つ本来の機能と役割を解明することで生命機能の統合的理解を計ります。またこの技術を活用し、正常と病態とのモデル動物での比較や、霊長類とヒトの比較、発生・発達・老化に関わる時間生物学観点からの研究を行います。

研究分野

生物学 & 生化学 / 薬学 & 毒物学 / 神経科学 & 行動科学

研究テーマ

• 次世代のオリジナルPETトレーサー候補化合物の創出
• 生物現象追跡のための分子イメージング技術

主要論文

1. Mizuma H, Shukuri M, Hayashi T, Watanabe Y, Onoe H.:
   Establishment of in vivo brain imaging method in conscious mice.
   J Nucl Med 51(7), 1068-1075 (2010).
2. Kawasaki T, Ago Y, Yano K, Araki R, Washida Y, Onoe H, Chaki S, Nakazato A, Hashimoto H, Baba A, Takuma K, Matsuda T.:
   Increased binding of cortical and hippocampal group II metabotropic glutamate receptors in isolation-reared mice.
   Neuropharmacology 60(2-3), 397-404 (2011).
3. * Kambe T, Motoi Y, Inoue R, Kojima N, Tada N, Kimura T, Sahara N, Yamashita S, Mizoroki T, Takashima A, Shimada K, Ishiguro K, Mizuma H, Onoe H, Mizuno Y, Hattori N.:
   Differential regional distribution of phosphorylated tau and synapse loss in the nucleus accumbens in tauopathy model mice.
   Neurobiol Dis 42(3), 404-14 (2011).
4. Takashima T, Yokoyama C, Mizuma H, Yamanaka H, Wada Y, Onoe K, Nagata H, Tazawa S, Doi H, Takahashi K, Morita M, Kanai M, Shibasaki M, Kusuhara H, Sugiyama Y, Onoe H, Watanabe Y.:
   Developmental Changes in P-glycoprotein Function in the Blood-Brain Barrier of Non-Human Primates: PET Study with R-11C-Verapamil and [11C]Oseltamivir.
   J Nucl Med 52(6), 950-7 (2011).
5. Shukuri M, Takashima-Hirano M, Tokuda K, Takashima T, Matsumura K, Inoue O, Doi H, Suzuki M, Watanabe Y, Onoe H.:
   In vivo expression of cyclooxygenase-1 in activated microglia/macrophages during neuroinflammation visualized by PET with 11C-Ketoprofen-methyl ester.
   J Nucl Med 52(7), 1094-101 (2011).
6. * Nishimura Y, Onoe H, Onoe K, Morichika Y, Tsukada H, Isa T.:
   Neural substrates for the motivational regulation of motor recovery after spinal-cord injury.
   PLoS ONE 6(9), e24854 (2011).
7. * Shimazawa M, Ito Y, Inokuchi Y, Yamanaka H, Nakanishi T, Hayashi T, Ji B, Higuchi M, Suhara T, Imamura K, Araie M, Watanabe Y, Onoe H, Hara H.:
   An Alteration in the Lateral Geniculate Nucleus of Experimental Glaucoma Monkeys: In vivo Positron Emission Tomography Imaging of Glial Activation.
   PLoS One 7(1), e30526 (2012).
8. Yokoyama C, Kawasaki A, Hayashi T, Onoe H.:
   Linkage Between the Midline Cortical Serotonergic System and Social Behavior Traits: Positron Emission Tomography Studies of Common Marmosets.
   Cereb Cortex (in press) (2012).
9. * Nakazawa S, Yokoyama C, Nishimura N, Horisawa T, Kawasaki A, Mizuma H, Doi H, Onoe H.:
   Evaluation of dopamine D(2)/D (3) and serotonin 5-HT (2A) receptor occupancy for a novel antipsychotic, lurasidone, in conscious common marmosets using small-animal positron emission tomography.
   Psychopharmacology (Berl) 225(2), 329-39 (2013).
10. * Yeh HH, Tian M, Hinz R, Young D, Shavrin A, Mukhapadhyay U, Flores LG, Balatoni J, Soghomonyan S, Jeong HJ, Pal A, Uthamanthil R, Jackson JN, Nishii R, Mizuma H, Onoe H, Kagawa S, Higashi T, Fukumitsu N, Alauddin M, Tong W, Herholz K, Gelovani JG.:
    Imaging epigenetic regulation by histone deacetylases in the brain using PET/MRI with (18)F-FAHA.
    Neuroimage 64, 630-9 (2013).