高次構造形成研究グループ

複雑な多細胞組織の形成機構について、細胞間の認識・接着、形態形成運動、神経組織のパターン形成、神経回路の形成、などの問題に焦点を当て、それらのメカニズムを研究しています。また、これらの研究の成果が、がんの浸潤・転移等の医学的問題の解決に役立つことを期待しています。

研究テーマ

• 形態形成のカドヘリンおよびカテニンによる制御機構
• がん細胞における細胞異常機構
• 神経回路形成における細胞認識機構
• 微小管動態と細胞構築

主要論文

1. Nagae, S., Meng, W., and Takeichi, M.:
   "Non-centrosomal microtubules regulate F-actin organization through the suppression of GEF-H1 activity."
   Genes to Cells in press. (2013)
2. Tanaka, N., Meng, W., Nagae, S., and Takeichi, M.:
   "Nezha/CAMSAP3 and CAMSAP2 cooperate in epithelial-specific organization of non-centrosomal microtubules. "
   Proc. Natl. Acad. Sci. USA. 109, 20029-20034 (2012)
3. Vassilev, V., Mandai, M., Yonemura, S., and Takeichi, M.:
   "Loss of N-cadherin from the endrothelium causes stromal edema and epithelial dysgenesis in the mouse cornea."
   Investigative Ophthalmology and Visual Science 53, 7183-7193 (2012)
4. Nishimura, T., Honda, H., and Takeichi, M.:
   "Planar cell polarity links axes of spatial dynamics in neuraltube closure."
   Cell 149, 1084-1097 (2012)
5. Hirano, S., and Takeichi, M.:
   "Cadherins in brain morphogenesis and wiring."
   Physiol. Rev. 92, 597-634 (2012)
6. Ishiuchi, T., and Takeichi M.:
   "Nectins localize Willin to cell-cell junctions."
   Genes Cells 17, 387-397(2012)
7. Taguchi, K., Ishiuchi, T., and Takeichi, M.:
   "Mechanosensitive EPLIN-dependent remodeling of adherens junctions regulates epithelial reshaping."
   J. Cell Biol. 194, 643-656 (2011)
8. Takeichi, M.:
   "Self-organization of animal tissues: cadherin-mediated processes."
   Dev. Cell 21, 24-26 (2011)
9. Togashi, H., Kominami, K., Waseda, M., Komura, H., Miyoshi, J., Takeichi, M., and Takai, Y.:
   "Nectins establish a checkerboard-like cellular pattern in the auditory epithelium."
   Science 333, 1144-1147 (2011)
10. Oda, H., and Takeichi, M.:
    "Structural and functional diversity of cadherin at the adherens junction."
    J. Cell Biol. 193, 1137-1146 (2011)