主要論文

1. Matsumoto, G., Wada, K., Okuno, M., Kurosawa, M. & Nukina, N.:
   " Serine 403 phosphorylation of p62/SQSTM1 regulates selective autophagic clearance of ubiquitinated proteins."
   Mol. Cell 44, 279-289 (2011).
2. Kino, Y., Washizu, C., Aquilanti, E., Okuno, M., Kurosawa, M., Yamada, M., Doi, H. & Nukina, N.:
   " Intracellular localization and splicing regulation of FUS/TLS are variably affected by amyotrophic lateral sclerosis-linked mutations."
   Nucleic Acids Res. 39, 2781-2798 (2011).
3. Bauer, P.O., Goswami, A., Wong, H.K., Okuno, M., Kurosawa, M., Yamada, M., Miyazaki, H., Matsumoto, G., Kino, Y., Nagai, Y. & Nukina, N.:
   " Harnessing chaperone-mediated autophagy for the selective degradation of mutant huntingtin protein."
   Nat. Biotechnol. 28, 256-263 (2010).
4. Furukawa, Y., Kaneko, K., Matsumoto, G., Kurosawa, M. & Nukina, N.:
   " Cross-seeding fibrillation of Q/N-rich proteins offers new pathomechanism of polyglutamine diseases."
   J. Neurosci. 29, 5153-5162 (2009).
5. Sakurai, T., Kaneko, K., Okuno, M., Wada, K., Kashiyama, T., Shimizu, H., Akagi, T., Hashikawa, T. and Nukina, N.:
   " Membrane microdomain switching: a regulatory mechanism of amyloid precursor protein processing."
   J. Cell Biol. 183, 339-352 (2008).
6. Wong, H.K., Bauer, P.O., Kurosawa, M., Goswami, A., Washizu, C., Machida, Y., Tosaki, A., Yamada, M., Knopfel, T., Nakamura, T. and Nukina, N.:
   " Blocking acid-sensing ion channel 1 alleviates Huntington's disease pathology via an ubiquitin-proteasome system-dependent mechanism."
   Hum. Mol. Genet. 17, 3223-3235 (2008).
7. Yamanaka, T., Miyazaki, H., Oyama, F., Kurosawa, M., Washizu, C., Doi, H. and Nukina, N.:
   " Mutant Huntingtin reduces HSP70 expression through the sequestration of NF-Y transcription factor."
   EMBO J. 27, 827-839 (2008).
8. Doi, H., Okamura, K., Bauer, P.O., Furukawa, Y., Shimizu, H., Kurosawa, M., Machida, Y., Miyazaki, H., Mitsui, K., Kuroiwa, Y. and Nukina, N.:
   " RNA-binding protein TLS is a major nuclear aggregate-interacting protein in huntingtin exon 1 with expanded polyglutamine-expressing cells."
   J. Biol. Chem. 283, 6489-6500 (2008).
9. Tanaka, M., Machida, Y., Niu, S., Ikeda, T., Jana, N-R., Doi, H., Kurosawa, M., Nekooki, M., and Nukina, N.:
   " Trehalose effectively alleviates polyglutamine-mediated pathology in a transgenic mouse model of Huntington's disease"
   Nat. Med. 10, 148-154 (2004).
10. Jana, N-R., Zemskov, E-A., Wang, G. and Nukina, N.:
    " Altered proteasomal function due to the expression of polyglutamine-expanded truncated N-terminal huntingtin induces apoptosis by caspase activation through mitochondrial cytochrome c release"
    Hum. Mol. Genet. 10, 1049-1059 (2001).

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