主要論文

1. Zhang, K. Y. J.:
   "SQUASH　-　Combining Constraints for Macromolecular Phase Refinement and Extension."
   Acta Cryst., D49,　213-222(1993).
2. Nieh, Y. P., and Zhang, K. Y. J.:
   "A two-dimensional histogram-matching method for protein phase refinement and extension."
   Acta Cryst., D55,　1893-1900(1999).
3. O'Neil, J. W., Johnsen, K.., Kim, D. E., Baker, D., and Zhang, K. Y. J.:
   "Single site multations induce 3D domain-swapping in the B1 domain of Protein L from Peptostreptococcus magnus."
   Structure, 9. 1017-1027(2001).
4. Zhang, K. Y. J.:
   "Multidimensional histograms for density modification."
   Methods in Enzymology, 374, 188-203(2003).
5. Zhang, K. Y. J., Card, G. L., Suzuki, Y., Artis, D. R., Fong, D., Gillette, S., Hsieh, D., Neiman, J., West, B. L., Zhang, C., Milburn, M. V., Kim, S. H., Schlessinger, J., and Bollag, G.:
   "A Glutamine Switch Mechanism for Nucleotide Selectivity by Phosphodiesterases."
   Molecular Cell, 15, 279-286(2004).
6. Card., G. L., Blasdel, L., England, B. P., Zhang, C., Suzuki, Y., Gillette, S., Fong, D., Ibrahim, P. N., Artis, D. R., Bollag, G., Milburn, M. V., Kim, S. H., Schlessinger, J., and Zhang, K. Y. J.:
   "A family of phosphodiesterase inhibitors discovered by cocrystallography and scaffold-based drug design."
   Nature Biotechnology, 23, 201-207(2005)
7. Zhang, K. Y. J.:
   "Crystal structure of PDE families and the potential for rational drug design."
   Chapter 29 in Cyclic Nucleotide Phosphodiesterases in Health and Disease, pp 583-605, Eds. Joseph A. Beavo, Sharron H. Francis and Miles D. Houslay, CRC Press, Boca Raton/London/New York(2006).
8. Zhang, K. Y. J., Milburn, M. V., and Artis, D. R.:
   "Scaffold-based drug discover."
   Chapter 6 in Structure-based Drug Discovery, pp 129-153, Eds. Harren Jhoti and Andrew Leach, Springer, Dordrecht/Boston/London(2007).
9. Tsai, J., Lee, J. T., Wang, W., Zhang, J. Z., Cho, H., Mamo, S., Bremer, R., Gillette, S., Kong, J. Haass, N. K., Sproesser, K., Li, L., Smalley, K. S. M., Fong, D., Zhu, Y. L., Marimuthu, A., Nguyen, H., Lam, B., Liu, J., Cheung, I., Rice, J., Suzuki, Y.:
   "Discovery of a Novel Selective Inhibitor of Oncogenic B-Raf Kinase with Potent Anti-Melanoma Activity."
   PNAS, 105, 3041-3046(2008)
10. Artis, D. R., Lin, J. J., Zhang, C., Wang, W. Mehra, U., Perreault, M., Erbe, d., Krupka, H. I., England, B. P., Arnold, J., Plotnikov, A. N., Marimuthu, A., Nguyen, H., Will, S., Signaevsky, M., Kral, J. Cantwell, J., Settachatgull, C., Yan, D. P., Hirth.:
    "Scaffold-based discovery of indeglitazar, a PPAR pan-active anti-diabetic agent."
    PNAS, 106, 262-267(2009)

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