Multiple Molecular Imaging Research Laboratory

Makoto Hiromura, Ph.D.

Research field : Molecular biology, Biochemistry

Papers

1. M Hiromura, Y Adachi, M Machida, M Hattori, H Sakurai, Glucose lowering activity by oral administration of bis(allixinato)oxidovanadium(IV) complex in streptozotocin-induced diabetic mice and gene expression profiling in their skeletal muscles, Metallomics, 1, 92-100, (2009)
2. M Hiromura, H Sakurai, Action mechanism of insulin-mimetic vanadyl-allixin complex, Chem. Biodivers., 8, 1615-21
3. A Nakayama, M Hiromura, Y Adachi, M Doi, H Sakurai, Molecular mechanism of antidiabetic zinc-allixin complexes: regulations of glucose utilization and lipid metabolism, J. Biol. Inorg. Chem., 13, 675-84, (2008).
4. M Hiromura, A Nakayama, Y Adachi, M Doi, H Sakurai, Action mechanism of bis (allixinato) oxovanadium (IV) as a novel potent insulin-mimetic complex, regulation of GLUT4 translocation and FoxO1 transcription factor, J. Biol. Inorg. Chem., 12, 1275-87, (2007).
5. T Fujimori, H Yasui, M Hiromura, H Sakurai, Suppressive effect of orally administered copper (II)-aspirinate (Cu2(asp)4) complex on the generation of reactive oxygen species in the skin of animals subjected to UVA exposure, Exp. Dermatol., 16, 746-52, (2007).
6. W Basuki, M Hiromura, H Sakurai, Molecular Mechanism for Antidiabetic Activity of [meso-Tetrakis(4-sulfonatophenyl)porphyrinato]oxovanadium (IV) (VO(tpps)) Complex. Studies on Akt Phosphorylation and GLUT4 Translocation in 3T3-L1 Adipocytes, Bull. Chem. Soc. Jpn., 80, 1605-1610, (2007).
7. W Basuki, M Hiromura, H Sakurai, Insulinomimetic Zn complex (Zn(opt)2) enhances insulin signaling pathway in 3T3-L1 adipocytes, J. Inorg. Biochem., 101, 692-9, (2007).
8. W Basuki, M Hiromura, Y Adachi, K Tayama, M Hattori, H Sakurai, Enhancement of insulin signaling pathway in adipocytes by oxovanadium(IV) complexes, Biochem. Biophys. Res. Commun., 349(3), 1163-70. 2006
9. M Hiromura, F Suizu, M Narita, K Kinowaki, M Noguchi, Identification of nerve growth factor-responsive element of the TCL1 promoter as a novel negative regulatory element, J Biol Chem., 281, 27753-64, (2006).
10. S Kataoka, H Yasui, M Hiromura, H Sakurai, Effect of insulin-mimetic vanadyl sulfate on cytochrome P450 2E1-dependent p-nitrophenol hydroxylation in the liver microsomes of streptozotocin-induced type 1 diabetic rats, Life Sci. 77, 2814-29, (2005).
11. M Angers, R Drouin, M Bachvarova, I Paradis, B Bissell, M Hiromura, A Usheva, D Bachvarov, In vivo DNase I-mediated footprinting analysis along the human bradykinin B1 receptor (BDKRB1) gene promoter, evidence for cell-specific regulation, Biochem J., 389, 37-46, (2005).
12. M Hiromura, F Okada, T Obata, D Auguin, T Shibata, C Roumestand, M Noguchi, Inhibition of Akt kinase activity by a peptide spanning the betaA strand of the proto-oncogene TCL1, J Biol Chem. 279, 53407-18, (2004).
13. CH Choi, G Kalosakas, KO Rasmussen, M Hiromura, AR Bishop, A Usheva, DNA dynamically directs its own transcription initiation, Nucleic Acids Res. 32, 1584-90, (2004).
14. CH Choi, M Hiromura, A Usheva, Transcription factor IIB acetylates itself to regulate transcription, Nature. 424, 965-9, (2003).
15. M Hiromura, CH Choi, NA Sabourin, H Jones, D Bachvarov, A Usheva, YY1 is regulated by O-linked N-acetylglucosaminylation (O-glcNAcylation).J Biol Chem. 278, 14046-52, (2003).
16. N Bodyak, PM Kang, M Hiromura, I Sulijoadikusumo, N Horikoshi, K Khrapko, A Usheva, Gene expression profiling of the aging mouse cardiac myocytes, Nucleic Acids Res. 30, 3788-94, (2002).
17. D Gao, M Hiromura, H Yasui, H Sakurai, Direct reaction between shikonin and thiols induces apoptosis in HL60 cells, Biol Pharm Bull. 25, 827-32, (2002).
18. M Hiromura, H Chino, T Sonoda, H Sakurai, Molecular cloning and characterization of a copper chaperone for copper/zinc superoxide dismutase from the rat, Biochem Biophys Res Commun. 275, 394-400, (2000).
19. M Hiromura, H Sakurai, Molecular cloning of rat ATX1 homologue protein, Biochem. Biophys. Res. Commun., 265, 509-12, (1999).
20. M Hiromura, M Yano, H Mori, M Inoue, H Kido, Intrinsic ADP-ATP exchange activity is a novel function of the molecular chaperone, Hsp70, J. Biol. Chem. 273, 5435-8, (1998).