BSI Group Director Katsuhiko Mikoshiba will be presented with the Naito Memorial Award for his work "Studies on the development and differentiation of the central nervous system - discovery of IP3 receptor and analysis of its function". A presentation ceremony will be held in Tokyo in March.
Summary:
By detailed analysis of the behavior and morphogenesis of normal mice compared with mutant mice, Dr. Mikoshiba succeeded in correlating behavior, morphology and molecules. With a unique method of analysis, he analyzed the molecular mechanism of neuronal positioning, lobule formation of the brain, myelination, and neural induction.
One of his pioneering works was the discovery of the IP3 receptor. He also found that the IP3 receptor is a calcium channel and is located at the endoplasmic reticulum inside the cell. He found that calcium release from endoplasmic reticulum through the IP3 receptor is essential for various phenomena in living systems. Some of the results are listed in the figure.
Reference:
The Naito Foundation (in Japanese only)
Dr. Katsuhiko Mikoshiba, CURRICULUM VITAE
Present Address:
- * Group Director,
- Neuro-Development Disorder Research Group,
Brain Science Institute, RIKEN
2-1 Hirosawa , Wako, Saitama 351-0198 JAPAN
- ** Research Director,
- Solution Oriented Research for Science and Technology
(calcium oscillation project)
Japan Science and Technology Agency (JST)
2-1 Hirosawa , Wako, Saitama 351-0198 JAPAN
Education:
| 1969 | M.D. Keio University School of Medicine |
| 1973 | Ph.D. (Dr. of Medical Science), Keio University |
Professional Training and Employment:
| 1974-1982 |
Assistant Professor, Department of Physiology,
Keio University School of Medicine |
| 1976-1977 |
Research Associate
Pasteur Institute, Paris, France (c/o Dr. Jean-Pierre Changeux) |
| 1982-1985 |
Associate Professor, Department of Physiology,
Keio University School of Medicine |
| 1985-1992 |
Professor, Division of Regulation of Macromolecular
Function, Institute for Protein Research, Osaka University |
| 1986-1991 |
Professor, Division of Behavior and Neurobiology,
National Institute for Basic Biology (Adjunct position) |
| 1992-1997 |
Chief Scientist, Molecular Neurobiology Laboratory,
The Institute of Physical and Chemical Research (RIKEN),
Tsukuba Life Science Center (Adjunct position) |
| 1992-2007 |
Professor, Department of Molecular Neurobiology,
Institute of Medical Science, University of Tokyo |
| 1995-Present |
Research Director, ICORP-SORST Japan Science and
Technology Agency (JST) |
| 1998-Present |
Team Leader, Laboratory for Developmental Neurobiology,
Group Director, Neuro-Development Disorder Research Group,
Brain Science Institute, RIKEN |
| 2003-Present |
Foreign Professor (Adjunct Professor), Karolinska Institute |
| 2004-Present |
Adjunct Professor, Jikeikai Medical School,
Yamagata University |
| 2005-Present |
Member, Science Council of Japan |
| 2007-Present |
Professor Emeritus, University of Tokyo |
Honors:
| 1997 | Uehara Prize (with Prof. Shigekazu Nagata) |
| 1998 | The Keio Medical Science Prize (International Prize) with Dr. M.J. Folkman |
| 2002 | Medal of Honor in Japan (Medal with Purple Ribbon-Emperor's Prize) |
| 2003 | Klaus Joachim Zülch -Preis (Germany • Max-Planck Institute, Gertrud
Reemtsma Foundation) with Professor Fred H. Gage (Salk Institute) |
| 2004 | Takeda Medical Science Prize (Takeda Foundation, Japan) |
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