Theoretical Biology Laboratory
Chief Scientist
Atsushi MOCHIZUKI (D.Sci.)
The progress of modern biology causes rapid increase in the information of molecular level. We now understand that the biological phenomena are governed by complex interactions between molecules, cells or organs and that the biological functions are emerged from the whole of the systems. We adopt mathematical or theoretical methods to decipher huge amounts of molecular information, and to give integrative understanding for the complex biological systems. We have multiple projects of collaboration works with experimental biologists. In these projects we try to derive testable prediction as far as possible. At the same time, we try to develop general theories originated from the context of modern biology.
- Solving biological problems by mathematical or theoretical methods
- Develop general theories originated from the context of modern biology
- Nakazato, K., and Mochizuki, A.:
"Steepness of thermal gradient is essential to obtain a unified view of thermotaxis in C. elegans."
J. theor. Biol. 2009, 260, 56-65. - Mochizuki, A.:
"Structure of regulatory networks and diversity of gene expression patterns."
J. theor. Biol. 250, 307-321 (2008) - Sugimura,K., Shimono,K., Uemura,T. and Mochizuki,A.:
"Self-organizing mechanism for development of space-filling neuronal dendrites."
PLoS Comput Biol. 3(11), 2143-2154 (2007) - Otsuji, M., Ishihara, S., Co, C., Kaibuchi, K., Mochizuki, A., and Kuroda, K.:
"A Mass Conserved Reaction-Diffusion System Captures Properties of Cell Polarity."
PLoS Comput Biol. 3(6), 1040-1054 (2007) - Ishihara, S., Otsuji, M., and Mochizuki, A.:
"Transient and steady state of mass-conserved reaction-diffusion systems."
Phys. Rev. E 75 (1), 015203-1 - 015203-4 (2007) - Nakamura, T., Mine, N., Nakaguchi, E., Mochizuki, A., Yamamoto, M., Yashiro, K., Meno, C.,and Hamada, H.:
"Generation of robust left-right asymmetry in the mouse embryo requires a self-enhancement and lateral-inhibition system."
Dev. Cell 11, 495-504 (2006) - Fujita, H.,and Mochizuki, A.:
"Fujita, H. & Mochizuki, A. (2006) The Origin of the Diversity of Leaf Venation Pattern."
Dev. Dyn. 235, 2710-2721 (2006) - Takigawa-Imamura, H.,and Mochizuki, A.:
"Predicting regulation of the phosphorylation cycle of KaiC clock protein using mathematical analysis."
J Biol. Rhythms 21, 405-416 (2006) - Fujita, H.,and Mochizuki, A.:
"Pattern formation by the positive feedback regulation between flow of diffusible signal molecule and localization of its carrier."
J. theor. Biol.241, 541-551 (2006) - Takigawa-Imamura, H.,and Mochizuki, A.:
"Transcriptional Autoregulation by Phosphorylated and Non-Phosphorylated KaiC in Cyanobacterial Circadian Rhythms."
J. theor. Biol. 241, 178-192 (2006)
Principal Investigator
- Atsushi MOCHIZUKI
- Chief Scientist
Staff Scientist
- Masashi TACHIKAWA
- Research Scientist
- Gen KUROSAWA
- Research Scientist
Postdoctoral Fellow
- Koh HASHIMOTO
- Contract Researcher
- Kenichi NAKAZATO
- Postdoctoral Researcher
- Daisuke SAITO
- Postdoctoral Researcher
- Masaki TSUDA
- Postdoctoral Researcher
- Koichiro URIU
- Visiting Researcher