Synthetic Organic Chemistry Laboratory
Our laboratory focuses on the following research areas based on synthetic organic chemistry: 1) development of new reactions and methodologies for the efficient synthesis of bioactive molecules, 2) design and synthesis of molecules having unique biological activity, 3) biological researches using these unique molecules as biological probes. Our research interests encompass from transition metal-catalyzed enantioselective reactions to the design and synthesis of intracellular signal transduction modulators and their application to cell biology research. Design and synthesis of selective inhibitors of protein kinases and phosphatases, which are involved in the signal transduction of cell proliferation, aiming for the clarification of the functions of their target enzymes are of particular interest. Clarification of the unknown molecular mechanism of cell death (necrosis) by using our original cell death control molecules is also currently underway. We are also working on the synthesis of ganglioside analogues and several other natural products having interesting biological activities.
- Development of novel catalytic enantioselective reactions
- Development of selective inhibitors of protein kinases and phosphatases
- Development of cell death inhibitors and clarification of their molecular mechanism of action
- Development of molecular probes for clarification of human sialidase functions
- Development of new chemical method for the chemical biology research
- September 19,2008
- Twisting around the palladium
A metal catalyst teaches an old chemical reaction new tricks![]()
- Ayako Tsuchiya, Go Hirai, Yusuke Koyama, Kana Oonuma, Yuko Otani, Hiroyuki Osada, and Mikiko Sodeoka.:
"Dual-specificity Protein Phosphatase CDC25A/B Inhibitor Identified from a Focused Library with Non-electrophilic Enamine Core Structure"
ACS Med. Chem. Lett. in press - Hiromichi Egami, Shinji Kamisuki, Kosuke Dodo, Miwako Asanuma, Yoshitaka Hamashima and Mikiko Sodeoka.:
"Catch & release of alkyne-tagged molecules in water by polymer-supported cobalt complex"
Org. Biomol. Chem. 9, 7667-7670 (2011). - Hiroyuki Yamakoshi, Kosuke Dodo, Masaya Okada, Jun Ando, Almar Palonpon, Katsumasa Fujita, Satoshi Kawata, and Mikiko Sodeoka.:
"Imaging of EdU, an Alkyne-Tagged Cell Proliferation Probe, by Raman Microscopy"
J. Am. Chem. Soc. 133, 6102-6105 (2011). - Go Hirai, Ayako Tsuchiya, Yusuke Koyama, Yuko Otani, Kana Oonuma, Kosuke Dodo, Siro Simizu, Hiroyuki Osada, and Mikiko Sodeoka.:
"Development of a Vaccinia H1-Related (VHR) Phosphatase Inhibitor with a NonAcidic Phosphate-Mimicking Core Structure"
ChemMedChem, 6, 617-622 (2011). - Eriko Iwasa, Yoshitaka Hamashima, Shinya Fujishiro, Eisuke Higuchi, Akihiro Ito, Minoru Yoshida, and Mikiko Sodeoka.:
"Total Synthesis of (+)-Chaetocin and its Analogues: Their Histone Methyltransferase G9a Inhibitory Activity"
J. Am. Chem. Soc. 132, 4078-4079 (2010). - Ayako Nakamura, Sylvain Lectard, Daisuke Hashizume, Yoshitaka Hamashima, and Mikiko Sodeoka.:
"Diastereo- and Enantioselective Conjugate Addition of α-Ketoesters to Nitroalkenes Catalyzed by a Chiral Ni(OAc)2 Complex under Mild Conditions"
J. Am. Chem. Soc. 132, 4036-4037 (2010). - Yuou Teng, Katsuya Iuchi, Eriko Iwasa, Shinya Fujishiro, Yoshitaka Hamashima, Kosuke Dodo, and Mikiko Sodeoka.:
"Unnatural enantiomer of chaetocin shows strong apoptosis-inducing activity through caspase-8/caspase-3 activation"
Bioorg. Med. Chem. Lett. 20, 5085-5088 (2010). - Ryo Shimizu, Hiromichi Egami, Tatsuya Nagi, Jungha Chae, Yoshitaka Hamashima, and Mikiko Sodeoka.:
"Direct C2-trifluoromethylation of indole derivatives catalyzed by copper acetate"
Tetrahedron Lett. 51, 5947-5949 (2010) - Mikiko Sodeoka and Kosuke Dodo.:
"Development of Selective Inhibitors of Necrosis"
Chemical Record 10, 308-314 (2010). - Megumi Ohkubo, Go Hirai, and Mikiko Sodeoka.:
"Synthesis of DFGH-ring System of Type B Physalins : A Characteristic Highly Oxygen-functionalized and Cage-shaped Molecule"
Angew. Chem. Int. Ed. 48, 3862-3866 (2009).
Principal Investigator
- Mikiko SODEOKA
- Chief Scientist
Staff Scientist
- Go HIRAI
- Senior Research Scientist
- Kosuke DODO
- Research Scientist
- Yoshihiro SOHTOME
- Research Scientist
Postdoctoral Fellow
- Tatsuo SAITO
- Special Postdoctoral Researcher
- Frederic THUAUD
- Visiting Researcher
- Joaquin Javier Barjau VALLET
- Visiting Researcher
- Masaaki OZAWA
- Postdoctoral Researcher
- Daiki HOJO
- Postdoctoral Researcher
Student Trainee
- Marie KATO
- Student Trainee
- Ryo SHIMIZU
- Junior Research Associate
- Kenji HAYAMIZU
- Junior Research Associate
- Masaki MORITA
- Student Trainee
- Eisuke OTA
- Junior Research Associate
- Motonari SAKAI
- Student Trainee
- Eri NISHIZAWA
- Student Trainee
- Genta NAKAMURA
- Student Trainee
- Yoshihiko USUI
- Student Trainee
- Yuta KURAMOTO
- Student Trainee
- Shuntaro KOJIMA
- Student Trainee
- Yuya HIKONE
- Student Trainee
Technical Assistant
- Kana OONUMA
- Technical Staff II
Visiting Research Staff
- Yuki TAMURA
- Visiting Scientist
- Miwako ASANUMA
- Visiting Scientist
- Hiromichi EGAMI
- Visiting Scientist
- Ayato SATO
- Visiting Scientist
- Tito AKINDELE
- Visiting Scientist
- Takao YAMAGUCHI
- Visiting Scientist
- Hiroyuki YAMAKOSHI
- Visiting Scientist
- Jun ANDO
- Visiting Scientist
- Masateru OKAZAKI
- Visiting Scientist
- Ayako MIYAZAKI
- Visiting Scientist
- Moon-Il KANG
- Visiting Scientist
- Yohei SAITO
- Visiting Scientist
- Shuichi NAKANISHI
- Visiting Scientist
- Shintaro KAWAMURA
- Visiting Scientist

