Nano Medical Engineering Laboratory

Chief Scientist
Yoshihiro ITO (D.Eng.)
This laboratory aims to create new functional materials by a new method which will be developed by combination of chemical and biotechnological methodology. We use organic synthetic chemistry, combinatorial chemistry, molecular engineering, polymer engineering, hybrid materials engineering, gene and protein engineering, microfabrication technology, and nanotechnology to synthesize new materials and the systems for development of regenerative medicine, artificial organs, drug delivery systems, nanomedicine, molecular imaging, biochips, bioelectronics, artificial enzymes and artificial antibodies.
- Biomaterials for regenerative medicine
- Nanomedicine using RNAi
- Development of microarray biochips
- Development of molecular probes for cellular imaging
- Development of high perfromance organic catalyst by combinatorial engineering
- Noveber 16, 2012
- Creating new products through 'bio-fabrication'
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- December 09, 2011
- Turning the spotlight on drug-resistant tumors
A newly developed group of fluorescent probes highlights cancer cells resistant to anticancer drugs![]()
- August 31, 2007
- All-round immobilization revolutionizes medicine
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- Kazuhiro Furukawa, Hiroshi Abe, Yasutsugu Tamura, Rei Yoshimoto, Minoru Yoshida, Satoshi Tsuneda and Yoshihiro Ito.:
"Fluorescent detection of intron lariat RNAs with reduction-triggered fluorescence probe"
Angew. Chem. Int. Edn., 50(50), 12020-12023 (2011) - Katarina Johansson, Mika Ito, Carolien Schophuizen, Sherin T. Mathew, Vanina Heuser, Jie Zhang, Miyuki Shimoji, Marie Vahter, Wee Han Ang, Paul Dyson, Aya Shibata, Satoshi Shuto, Yoshihiro Ito, Hiroshi Abe, and Ralf Morgenstern.:
"Characterization of new potential anti-cancer drugs designed to overcome glutathione transferase mediated resistance"
Mol. Pharma., 8, 1698-1708 (2011) - Jie Zhang, Aya Shibata, Mika Ito, Satoshi Shuto, Yoshihiro Ito, Bengt Mannervik, Hiroshi Abe, and Ralf Morgenstern.:
"Synthesis and characterization of a series of highly fluorogenic substrates for glutathione transferases, a general strategy"
J. Am. Chem. Soc., 133, 14109-14119 (2011) - Binata Joddar, Takashi Kitajima, and Yoshihiro Ito.:
"The effects of covalently immobilized hyaluronic acid substrates on the adhesion, expansion, and differentiation of embryonic stem cells for in vitro tissue engineering"
Biomaterials, 32, 8404-8415(2011) - Wei Wang, Shuta Hara, Mingzhe Liu, Toshiro Aigaki, Shigeru Shimizu, and Yoshihiro Ito.:
"Polypeptide aptamer selection using a stabilized ribosome display"
J. Biosci. Bioeng., 112(5), 515-517(2011) - Naoko Abe, Hiroshi Abe, Chisato Nagai, Mitsuru Harada, Hiroto Hatakeyama, Hideyoshi Harashima, Takahito Ohshiro, Mizuki Nishihara, KazuhiroFurukawa, Mizuo Maeda, Satoshi Tsuneda, and Yoshihiro Ito.:
"Synthesis, structure, and biological activity of dumbbell-shaped nanocircular RNAs for RNA interference"
Bioconj. Chem., 22, 2082-2092 (2011) - Makoto Sakuragi, Takashi Kitajima, Teruyuki Nagamune, and Yoshihiro Ito.:
"Recombinant hBMP4 incorporated with non-canonical amino acid for binding to hydroxyapatite"
Biotechnol. Lett., 33, 1885-1890(2011) - Yuko Nakashima, Hiroshi Abe, Naoko Abe, Kyoko Aikawa, and Yoshihiro Ito.:
"Branched RNA nanostructures for RNA interference"
Chem. Commun., 47(29), 8367-8369(2011) - Takashi Kitajima, Sei Obuse, Takahiro Adachi, Masahiro Tomita and Yoshihiro Ito.:
"Recombinant human gelatin substitute with photoreactive properties for cell culture and tissue engineering"
Biotechnol. Bioeng., 108(10), 2468-2476(2011) - Naoko Abe, Hiroshi Abe, Takahito Oshiro, Yuko, Nakashima, Mizuo Maeda, and Yoshihiro Ito.:
"Synthesis and characterization of small circular double-stranded RNAs"
Chem Commun. , 47, 2125-2127 (2011)
Principal Investigator
- Yoshihiro ITO
- Chief Scientist
Staff Scientist
- Hiroshi ABE
- Senior Research Scientist
- Takanori UZAWA
- Research Scientist
Postdoctoral Fellow
- Aya SHIBATA
- Special Postdoctoral Researcher
- Yuko NAKASHIMA
- Special Postdoctoral Researcher
- Binata JODDAR
- Foreign Postdoctoral Researcher
- Di ZHOU
- Foreign Postdoctoral Researcher
- Takashi KITAJIMA
- Contract Researcher
- Kyoji HAGIWARA
- Contract Researcher
- Hisao SANEYOSHI
- Postdoctoral Researcher
- Seiichi TADA
- Postdoctoral Researcher
- Yukiko NAKANO
- Postdoctoral Researcher
- Kenya KOBAYASHI
- Postdoctoral Researcher
- Wei WANG
- Postdoctoral Researcher
- Sivakumar Malliappan PONNURENGAM
- Visiting Researcher
- Kazumitsu ONIZUKA
- Visiting Researcher
Student Trainee
- Pallavi Ananda KADENGODLU
- Junior Research Associate
- Zha LI
- Junior Research Associate
- Hideto MARUYAMA
- Junior Research Associate
- Yasodha MANANDHAR
- Junior Research Associate