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Nano Medical Engineering Laboratory
Yoshihiro ITO
Chief Scientist
Yoshihiro ITO (D.Eng.)
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Research Areas

This laboratory aims to create new functional materials by a new method which will be developed by combination of chemical and biotechnological methodology. We use organic synthetic chemistry, combinatorial chemistry, molecular engineering, polymer engineering, hybrid materials engineering, gene and protein engineering, microfabrication technology, and nanotechnology to synthesize new materials and the systems for development of regenerative medicine, artificial organs, drug delivery systems, nanomedicine, molecular imaging, biochips, bioelectronics, artificial enzymes and artificial antibodies.

Research Subject

  1. Biomaterials for regenerative medicine
  2. Nanomedicine using RNAi
  3. Development of microarray biochips
  4. Development of molecular probes for cellular imaging
  5. Development of high perfromance organic catalyst by combinatorial engineering

Related links

  1. RIKEN Advanced Science Institute Website_Laboratories PageNew Window
  2. Individual Website Laboratory PageNew Window

Press release

November 15, 2007
Nano production techniques applied to gene-switching RNA
Researchers find a means to extend the useful life of synthetic RNA that could be utilized to safely combat hereditary diseases. New Window

RIKEN RESEARCH

Noveber 16, 2012
Creating new products through 'bio-fabrication'New Window
December 09, 2011
Turning the spotlight on drug-resistant tumors
A newly developed group of fluorescent probes highlights cancer cells resistant to anticancer drugs New Window
May 16, 2008
No loose ends
Tying short RNA molecules into loops gives them a stability boost, which could lead to more effective therapeutic strategies for modulating gene expression New Window
August 31, 2007
All-round immobilization revolutionizes medicine New Window

List of Selected Publications

  1. Kazuhiro Furukawa, Hiroshi Abe, Yasutsugu Tamura, Rei Yoshimoto, Minoru Yoshida, Satoshi Tsuneda and Yoshihiro Ito.:
    "Fluorescent detection of intron lariat RNAs with reduction-triggered fluorescence probe"
    Angew. Chem. Int. Edn., 50(50), 12020-12023 (2011)
  2. Katarina Johansson, Mika Ito, Carolien Schophuizen, Sherin T. Mathew, Vanina Heuser, Jie Zhang, Miyuki Shimoji, Marie Vahter, Wee Han Ang, Paul Dyson, Aya Shibata, Satoshi Shuto, Yoshihiro Ito, Hiroshi Abe, and Ralf Morgenstern.:
    "Characterization of new potential anti-cancer drugs designed to overcome glutathione transferase mediated resistance"
    Mol. Pharma., 8, 1698-1708 (2011)
  3. Jie Zhang, Aya Shibata, Mika Ito, Satoshi Shuto, Yoshihiro Ito, Bengt Mannervik, Hiroshi Abe, and Ralf Morgenstern.:
    "Synthesis and characterization of a series of highly fluorogenic substrates for glutathione transferases, a general strategy"
    J. Am. Chem. Soc., 133, 14109-14119 (2011)
  4. Binata Joddar, Takashi Kitajima, and Yoshihiro Ito.:
    "The effects of covalently immobilized hyaluronic acid substrates on the adhesion, expansion, and differentiation of embryonic stem cells for in vitro tissue engineering"
    Biomaterials, 32, 8404-8415(2011)
  5. Wei Wang, Shuta Hara, Mingzhe Liu, Toshiro Aigaki, Shigeru Shimizu, and Yoshihiro Ito.:
    "Polypeptide aptamer selection using a stabilized ribosome display"
    J. Biosci. Bioeng., 112(5), 515-517(2011)
  6. Naoko Abe, Hiroshi Abe, Chisato Nagai, Mitsuru Harada, Hiroto Hatakeyama, Hideyoshi Harashima, Takahito Ohshiro, Mizuki Nishihara, KazuhiroFurukawa, Mizuo Maeda, Satoshi Tsuneda, and Yoshihiro Ito.:
    "Synthesis, structure, and biological activity of dumbbell-shaped nanocircular RNAs for RNA interference"
    Bioconj. Chem., 22, 2082-2092 (2011)
  7. Makoto Sakuragi, Takashi Kitajima, Teruyuki Nagamune, and Yoshihiro Ito.:
    "Recombinant hBMP4 incorporated with non-canonical amino acid for binding to hydroxyapatite"
    Biotechnol. Lett., 33, 1885-1890(2011)
  8. Yuko Nakashima, Hiroshi Abe, Naoko Abe, Kyoko Aikawa, and Yoshihiro Ito.:
    "Branched RNA nanostructures for RNA interference"
    Chem. Commun., 47(29), 8367-8369(2011)
  9. Takashi Kitajima, Sei Obuse, Takahiro Adachi, Masahiro Tomita and Yoshihiro Ito.:
    "Recombinant human gelatin substitute with photoreactive properties for cell culture and tissue engineering"
    Biotechnol. Bioeng., 108(10), 2468-2476(2011)
  10. Naoko Abe, Hiroshi Abe, Takahito Oshiro, Yuko, Nakashima, Mizuo Maeda, and Yoshihiro Ito.:
    "Synthesis and characterization of small circular double-stranded RNAs"
    Chem Commun. , 47, 2125-2127 (2011)

Members

Principal Investigator

Yoshihiro ITO
Chief Scientist

Staff Scientist

Hiroshi ABE
Senior Research Scientist
Takanori UZAWA
Research Scientist

Postdoctoral Fellow

Aya SHIBATA
Special Postdoctoral Researcher
Yuko NAKASHIMA
Special Postdoctoral Researcher
Binata JODDAR
Foreign Postdoctoral Researcher
Di ZHOU
Foreign Postdoctoral Researcher
Takashi KITAJIMA
Contract Researcher
Kyoji HAGIWARA
Contract Researcher
Hisao SANEYOSHI
Postdoctoral Researcher
Seiichi TADA
Postdoctoral Researcher
Yukiko NAKANO
Postdoctoral Researcher
Kenya KOBAYASHI
Postdoctoral Researcher
Wei WANG
Postdoctoral Researcher
Sivakumar Malliappan PONNURENGAM
Visiting Researcher
Kazumitsu ONIZUKA
Visiting Researcher

Student Trainee

Pallavi Ananda KADENGODLU
Junior Research Associate
Zha LI
Junior Research Associate
Hideto MARUYAMA
Junior Research Associate
Yasodha MANANDHAR
Junior Research Associate