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Molecular Genetics Laboratory
Shunsuke ISHII
Distinguished Senior Scientist
Shunsuke ISHII (D.Sci.)
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Research Areas

Regulation of transcription, a process of mRNA synthesis from DNA, is a basis of biological phenomena. Our laboratory aims to solve the mechanism of transcriptional control via analyzing transcriptional regulators. The finding that the mediators induce acetylation or deacetylation of histone indicated the important role of histone modification. Recently, epigenetic regulation via histone methylation has been focused, because this modification can be maintained for long period. We are analyzing various transcription factors which control cellular proliferation, development, and differentiation. Furthermore, using mice and Drosophila, we are analyzing diseases caused by abnormalities of these transcription factors.

Research Subject

  1. Nuclear oncogene product as a transcriptional regulator
  2. Gene expression by extracellular stimuli
  3. Genetic study of transcription factor using Drosophila

Related links

  1. RIKEN Advanced Science Institute Website_Laboratories PageNew Window
  2. Individual Website Laboratory PageNew Window

Press release

July 24, 2011
Mechanism for stress-induced epigenetic inheritance uncovered in new study

RIKEN RESEARCH

November 11,2011
Inheriting stress
Flies can pass the effects of stress to their young in the form of chromosomal modifications that alter expression of selected genes New Window

List of Selected Publications

  1. Seong KH, Li D, Shimizu H, Nakamura R & Ishii S.:
    "Inheritance of stress-induced, ATF-2-dependent epigenetic change. "
    Cell, 145, 1049-1061 (2011).
  2. Maekawa T, Kim S, Nakai D, Makino C, Takagi T, Ogura H, Yamada K, Chatton B & Ishii S.:
    "Social isolation stress induces ATF-7 phosphorylation and impairs silencing of the 5-HT 5B receptor gene."
    EMBO J., 29, 196-208 (2010).
  3. Yamauchi T, Ishidao T, Nomura T, Shinagawa T, Tanaka Y, Yonemura S & Ishii S.:
    "A B-Myb complex containing clathrin and filamin is required for mitotic spindle function."
    EMBO J., 27, 1852-1862 (2008).
  4. Jin W, Takagi T, Kanesashi S, Kurahashi T, Nomura T, Harada J & Ishii S.:
    "Schnurri-2 controls BMP-dependent adipogenesis via interaction with Smad proteins."
    Dev. Cell, 10, 461-471 (2006).
  5. Kanei-Ishii C, Ninomiya-Tsuji J, Tanikawa J, Nomura T, Ishitani T, Kishida S, Kokura K, Kurahashi T, Ichikawa-Iwata E, Kim Y, Matsumoto K & Ishii S.:
    "Wnt-1 signal induces phosphorylation and degradation of c-Myb protein via TAK1, HIPK2, and NLK."
    Genes Dev., 18, 816-829 (2004).
  6. Dai P, Akimaru H & Ishii S.:
    "A Hedgehog-responsive region in the Drosophila wing disc is defined by debra-mediated ubiquitination and lysosomal degradation of Ci."
    Dev. Cell, 4, 917-928 (2003).
  7. Shinagawa T & Ishii S.:
    "Generation of Ski-knock down mice by expressing a long double-strand RNA from an RNA polynerase II promoter."
    Genes Dev., 17, 1340-1345 (2003).
  8. Tahirov TH, Sato K, Ichikawa-Iwata E, Sasaki M, Inoue-Bungo T, Shiina M, Takata S, Fujikawa A, Morii H, Kumasaka T, Yamamoto M, Ishii S & Ogata K.:
    "Mechanism of c-Myb-C/EBPb cooperation from distantly separated sites on a promoter."
    Cell, 108, 57-70 (2002).
  9. Dai P, Shinagawa T, Nomura T, Harada J, Kaul SC, Wadhwa R, Akimaru H, Sasaki H, Colmenares C & Ishii S.:
    "Ski is involved in transcriptional regulation by the repressor and full-length forms of Gli3."
    Genes Dev., 16, 2843-2848 (2002).
  10. Okada M, Akimaru H, Hou DX, Takahashi T & Ishii S.:
    "Myb controls G2/M progression by inducing cyclin B expression in the Drosophila eye imaginal disc."
    EMBO J., 21,675-684 (2002).

Members

Principal Investigator

Shunsuke ISHII
Distinguished Senior Scientist

Staff Scientist

Toshie SHINAGAWA
Senior Research Scientist
Toshio MAEKAWA
ASI Research Scientist
Ki-Hyeon SEONG
ASI Research Scientist

Postdoctoral Fellow

Keisuke YOSHIDA
Special Postdoctoral Researcher
Ryoichi NAKAMURA
Postdoctoral Researcher
Daisuke TSUKAMOTO
Postdoctoral Researcher
Dong LI
Postdoctoral Researcher

Student Trainee

BinBin LIU
Junior Research Associate
Md. Mahabub-Uz ZAMAN
International Program Associate
Linh My HUYNH
Student Trainee

Technical Assistant

Yuko IIJIMA
Technical Staff I
Kaori YOSHIBA
Technical Staff II
Megumi TAKEMURA
Technical Staff II
Yuko MARUYAMA
Technical Staff II