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Bioengineering Laboratory
Mizuo MAEDA
Chief Scientist
Mizuo MAEDA (D.Eng.)
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Research Areas

The principal purpose of the laboratory is to explore a new frontier of research field which fuses engineering and biological science. On the basis of polymer chemistry, analytical chemistry, surface chemistry, biochemistry and molecular biology, we are studying on new materials comprising biological components, novel methodology for bioanalysis and medical diagnosis, and artificial systems for regulation of biological processes. Those new ideas and materials are being applied to the field of biomaterials science, environmental science, micro/nanoscience, life science and medical engineering. For example, we newly prepared DNA-vinyl polymer conjugates which have been applied for DNA biosensor, affinity electrophoresis, SNPs-responsive diagnostic nanoparticle, gene-responsive hydrogel, artificial gene regulation system, etc. These researches may be classified into a new category, i.e., "DNA engineering".

Research Subject

  1. DNA Conjugate Chemistry
  2. Bioanalytical Systems Engineering
  3. Biomacromolecular Science

Related links

  1. RIKEN Advanced Science Institute Website_Laboratories PageNew Window
  2. Individual Website Laboratory PageNew Window

Press release

November 8, 2012
New portable device enables RNA detection from ultra-small sample in only 20 minutes
April 21, 2009
Low-toxicity insulin-amyloid fibrils discovered that have a noodle rather than needle shape, marking a step toward clarifying the riddle of the toxic effects of needle amyloid in Alzheimer's disease
November 14, 2008
Elucidating a miraculous entero-symbiosis which supports the highly efficient decomposition of wood by termites, showing a multi-symbiotic mechanism between protists and bacteria

RIKEN RESEARCH

December 11,2009
Stacking at the flick of a switch
A switch that controls formation of stacks from nucleic acid strands has potential applications in gene expression and molecular machines New Window
August 07,2009
Giving DNA segments the golden touch
Controlled positioning of nucleic acids on gold nanoparticles creates new possibilities for bottom-up nanotechnologies New Window
July 03,2009
Of fibers and filaments
A chance observation leads to potential insights into the basis for cell damage associated with disorders like Alzheimer’s disease New Window
April 03, 2009
Partners in crime
A genomic study reveals important details about how microbes dwelling in the termite gut help their insect hosts to wreak havoc New Window
February 13, 2009
Making the switch for DNA
New switches could lead the way in controlling DNA duplex formation with potential nanotechnology applications New Window

List of Selected Publications

  1. Ooi, W. Y., Fujita, M., Pan, P., Tang, H. Y., Sudesh, K., Ito, K., Kanayama, N., Takarada, T., and Maeda, M.:
    "Structural Characterization of Nanoparticles from Thermoresponsive Poly(N-isopropylacrylamide)-DNA Conjugate"
    J. Colloid Interface Sci., in press.
  2. Han, A., Hosokawa, K., and Maeda, M.:
    "Activity Measurement of Protein Kinase and Protein Phosphatase by Microchip Phosphate-Affinity Electrophoresis"
    Anal. Biochem., 421, 782-784 (2012).
  3. Hiraishi, T., Yamashita, K., Sakono, M., Nakanishi, J., Tan, L. Z., Sudesh, K., Abe, H., and Maeda, M.:
    "Display of Functionally Active PHB Depolymerase on Escherichia Coli Cell Surface"
    Macromol. Biosci., 12, 218-224 (2012).
  4. Zako, T., Sakono, M., Kobayashi, T., Sorgjerd, K., Nilsson, K. P., Hammarstrom, P., Lindgren, M., and Maeda, M.:
    "Cell Interaction Study of Amyloid Using Luminescent Conjugated Polythiophene: Implication that Amyloid Cytotoxicity is Correlated with Prolonged Cellular Binding"
    ChemBioChem, 13, 358-363 (2012).
  5. Ozasa, K., Lee, J., Song, S., Hara, M., and Maeda, M.:
    "Two-Dimensional Optical Feedback Control of Euglena Confined in Closed-Type Microfluidic Channels"
    Lab Chip, 11, 1933-1940 (2011).
  6. Ogasawara, S., and Maeda, M.:
    "Photoresponsive 5'-Cap for the Reversible Photoregulation of Gene Expression"
    Bioorg. Med. Chem. Lett., 21, 5457-5459 (2011).
  7. Hiraishi, T., Komiya, N., Matsumoto, N., Abe, H., Fujita, M., and Maeda, M.:
    "Degradation and Adsorption Characteristics of PHB Depolymerase as Revealed by Kinetics for the Mutant Enzymes with Amino Acid Substitution in Substrate-Binding Domain"
    Biomacromolecules, 11, 113-119 (2010).
  8. Sakono, M., Zako, T., Drakulic, S., Valpuesta, J. M., Yohda, M., and Maeda, M.:
    "Size-Selective Recognition of Gold Nanoparticles by a Molecular Chaperone"
    Chem. Phys. Lett., 501, 108-112 (2010).
  9. Hosokawa, K., and Maeda, M.:
    "Spatial Distribution of Laminar Flow-Assisted Dendritic Amplification"
    Lab Chip, 9, 464-468 (2009).
  10. Kanayama, N., Shibata, H., Kimura, A., Miyamoto, D., Takarada, T., and Maeda, M.:
    "RAFT-Generated Polyacrylamide-DNA Block Copolymers for Single-Nucleotide Polymorphism Genotyping by Affinity Capillary Electrophoresis"
    Biomacromolecules, 10, 805-813 (2009).

Members

Principal Investigator

Mizuo MAEDA
Chief Scientist

Staff Scientist

Kazunari OZASA
Senior Research Scientist
Tamotsu ZAKO
Senior Research Scientist
Tomohiro HIRAISHI
Senior Research Scientist
Kazuo HOSOKAWA
Senior Research Scientist
Masahiro FUJITA
Senior Research Scientist
Tohru TAKARADA
Senior Research Scientist
Naoki KANAYAMA
ASI Research Scientist

Postdoctoral Fellow

SangWook LEE
Foreign Postdoctoral Researcher
Ken-Ichi WADA
Contract Researcher
Yoshitsugu AKIYAMA
Contract Researcher
Ryo ISHIHARA
Postdoctoral Researcher
Karin Margareta SORGJERD
Postdoctoral Researcher

Student Trainee

Eitaro KONDO
Junior Research Associate
Yi Chun CHEN
International Program Associate
Tong BU
International Program Associate
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