Bioengineering Laboratory
Chief Scientist
Mizuo MAEDA (D.Eng.)
The principal purpose of the laboratory is to explore a new frontier of research field which fuses engineering and biological science. On the basis of polymer chemistry, analytical chemistry, surface chemistry, biochemistry and molecular biology, we are studying on new materials comprising biological components, novel methodology for bioanalysis and medical diagnosis, and artificial systems for regulation of biological processes. Those new ideas and materials are being applied to the field of biomaterials science, environmental science, micro/nanoscience, life science and medical engineering. For example, we newly prepared DNA-vinyl polymer conjugates which have been applied for DNA biosensor, affinity electrophoresis, SNPs-responsive diagnostic nanoparticle, gene-responsive hydrogel, artificial gene regulation system, etc. These researches may be classified into a new category, i.e., "DNA engineering".
- DNA Conjugate Chemistry
- Bioanalytical Systems Engineering
- Biomacromolecular Science
- April 21, 2009
- Low-toxicity insulin-amyloid fibrils discovered that have a noodle rather than needle shape, marking a step toward clarifying the riddle of the toxic effects of needle amyloid in Alzheimer's disease
- November 14, 2008
- Elucidating a miraculous entero-symbiosis which supports the highly efficient decomposition of wood by termites, showing a multi-symbiotic mechanism between protists and bacteria
- Pan, P., Fujita, M., Ooi, W. Y., Sudesh, K., Takarada, T., Goto, A., and Maeda, M.:
"DNA-Functionalized Thermoresponsive Bioconjugates Synthesized via ATRP and Click Chemistry"
Polymer, 52, 895-900 (2011). - Hiraishi, T., Masuda, E., Miyamoto, D., Kanayama, N., Abe, H., and Maeda, M.:
"Enzymatic Synthesis of Poly(α-ethyl β-aspartate) by Polyethylene Glycol-Modified Poly(aspartate) Hydrolase-1"
Macromol. Biosci., 11, 187-191 (2011). - Sakono, M., Zako, T., Drakulic, S., Valpuesta, J. M., Yohda, M., and Maeda, M.:
"Size-Selective Recognition of Gold Nanoparticles by a Molecular Chaperone"
Chem. Phys. Lett., 501, 108-112 (2010). - Hiraishi, T., Komiya, N., Matsumoto, N., Abe, H., Fujita, M., and Maeda, M.:
"Degradation and Adsorption Characteristics of PHB Depolymerase as Revealed by Kinetics for the Mutant Enzymes with Amino Acid Substitution in Substrate-Binding Domain"
Biomacromolecules, 11, 113-119 (2010). - Ozasa, K., Aono, M., Maeda, M., and Hara, M.:
"Simulation of Neurocomputing Based on the Photophobic Reactions of Euglena with Optical Feedback Stimulation"
Biosystems, 100, 101-107 (2010). - Ohshiro, T., and Maeda, M.:
"Single-Molecule Imaging of DNA Duplexes Immobilized on Surfaces with a Scanning Tunneling Microscope"
Chem. Commun, 46, 2581-2583 (2010). - Hosokawa, K., and Maeda, M.:
"Spatial Distribution of Laminar Flow-Assisted Dendritic Amplification"
Lab Chip, 9, 464-468 (2009). - Kanayama, N., Shibata, H., Kimura, A., Miyamoto, D., Takarada, T., and Maeda, M.:
"RAFT-Generated Polyacrylamide-DNA Block Copolymers for Single-Nucleotide Polymorphism Genotyping by Affinity Capillary Electrophoresis"
Biomacromolecules, 10, 805-813 (2009). - Zako, T., Sakono, M., Hashimoto, N., Ihara, M., and Maeda, M.:
"Bovine Insulin Filaments Induced by Reducing Disulfide Bonds Show a Different Morphology, Secondary Structure, and Cell Toxicity from Intact Insulin Amyloid Fibrils"
Biophys. J., 96, 3331-3340 (2009). - Ogasawara, S. and Maeda, M.:
"Reversible Photoswitching of a G-Quadruplex"
Angew. Chem. Int. Ed., 48, 6671-6674 (2009).
Principal Investigator
- Mizuo MAEDA
- Chief Scientist
Staff Scientist
- Kazunari OZASA
- Senior Research Scientist
- Tamotsu ZAKO
- Senior Research Scientist
- Tomohiro HIRAISHI
- Senior Research Scientist
- Kazuo HOSOKAWA
- Senior Research Scientist
- Masahiro FUJITA
- Senior Research Scientist
- Tohru TAKARADA
- Senior Research Scientist
Postdoctoral Fellow
- Makoto TAKEMASA
- Special Postdoctoral Researcher
- Aya MIZUTANI
- Special Postdoctoral Researcher
- Karin Margareta SORGJERD
- Foreign Postdoctoral Researcher
- Naoki KANAYAMA
- Contract Researcher
- Ken-Ichi WADA
- Contract Researcher
Student Trainee
- Wei Yang OOI
- International Program Associate
- Liu Tzea TAN
- International Program Associate
- Yi Chun CHEN
- International Program Associate
- Tong BU
- International Program Associate