Molecular Characterization Team
Team Head
Hiroyuki KOSHINO (D.Agr.)
Our team provides diverse research support for molecular characterization. We develop new methods and technologies for structural elucidation of new organic compounds that are important in chemistry and related scientific fields such as chemical biology research. We maintain and operate MS, NMR, and CD instruments for researchers. Our research supporting activities include training on the machine use, technical assistance, acquisition of spectral data, and data analysis for structural determination of organic compounds. We support and collaborate with many research groups and continue to improve our capability and methodology for structural determination by spectroscopic analysis together with organic synthesis.
- Research support activity on mass spectrometry
- Research support activity on NMR
- Structural determination by spectroscopic methods and organic synthesis
- Development of new methods and technologies for NMR and MS analyses
- May 11 ,2011
- World's first MRI images taken using high-temperature superconducting bulk magnets
- October 26, 2007
- Techniques and skills rise to the challenge in structural analysis
- Ye, Y.-Q., Koshino, H., Onose, J., Yoshikawa, K., Abe, N., and Takahashi, S.:
"Expeditious synthesis of vialinin B, an extremely potent inhibitor of TNF-α production"
Org. Lett., 11, 5074 (2009). - Ye, Y.-Q., Koshino, H., Onose, J., Negishi, C., Yoshikawa, K., Abe, N., and Takahashi, S.:
"Structural revision of thelephantin G by total synthesis and the inhibitory activity against TNF-α production"
J. Org. Chem., 74, 4642 (2009). - Tani, H., Takahashi, S., Hasumi, K., Tatefuji, T., Hongo, Y., and Koshno, H.:
"Isolation of (E)-9,10-dihydroxy-2-decenoic acid from royal jelly and determination of the absolute configuration by chemical synthesis"
Tetrahedron: Asynmmetry, 20, 457 (2009). - Malon, M., Imakubo, T., and Koshino, H.:
"1H, 13C and 77Se NMR study of tetraselenafulvalene derivatives supported by novel H(Se)C and H(C)Se triple-resonance experiments at natural abundance"
Magn. Reson. Chem., 46, 150 (2008). - Hongo, Y., Sato, A., and Nakamura, T.:
"Factors governing peptide backbone cleavages in electron capture dissociation of triantennary complex-type N-glycosylated peptide"
J. Mass Spect. Soc. Jpn., 55, 279 (2007). - Hongo, Y., Li, B., Suzuki, K., and Nakamura, T.:
"An unexpected [M+I]+ ion formation in phosphasilene compounds detection by electrospray ionization mass spectrometry"
J. Mass Spectrom., 46, 956 (2011). - Ogawa, K., Nakamura, T., Terada, Y., Kose, K., and Haishi, T.:
"Development of a magnetic resonance microscope using a high Tc bulk superconducting magnet"
Appl. Phys. Lett., 98, 234101 (2011). - Izuchi, Y., Koshino, H., Hongo, Y., Kanomata, N., and Takahashi, S.:
"Synthesis and structural revision of phomopsin B, a novel polyketide carrying a 10-membered cyclic-ether ring"
Org. Lett., 13, 3360 (2011). - Guo, F., Nishiura, M., Koshino, H., and Hou, Z.:
"Cycloterpolymerization of 1,6-heptadiene with ethylene and styrene catalyzed by a THF-free half-sandwich scandium complex"
Macromolecules, 44, 2400 (2011). - Cho, S.-M., Yun, B.-S., Yoo, I.D., and Koshino, H:
"Structure of formitellan A, a mannofucogalactan from the fruiting bodies of Fomitella fraxinea"
Bioorg. Med. Chem. Lett., 21, 204 (2011).
Principal Investigator
- Hiroyuki KOSHINO
- Team Head
Staff Scientist
- Shun-ya TAKAHASHI
- Senior Research Scientist
- Takemichi NAKAMURA
- Senior Research Scientist
- Takashi NAKAMURA
- Senior Technical Scientist
- Yayoi HONGO
- Senior Technical Scientist
Student Trainee
- Daiki TAMADA
- Junior Research Associate