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Viral Infectious Diseases Unit
Yoko AIDA
Unit Leader
Yoko AIDA (D.V.M., Ph.D.)
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Research Areas

Currently, infections account for about 30% of annual mortalities worldwide, and it is feared that the ratio may rise abruptly in the future. This is because new viral infections have recently emerged one after another. One representative of such infections is AIDS, which kills about three million people every year. As well as human immunodeficiency virus type I (HIV-I) is the etiologic agents of AIDS, human T cell leukemia virus type I (HTLV-I) induced adult T-cell leukemia (ATL) and bovine leukemia virus (BLV) induced enzootic bovine leukosis (EBL) constitute a unique subgroup within the retrovirus family. The main subject of our unit is to understand the molecular mechanisms of AIDS induced by HIV-I and leukemogenesis induced by HTLV-I and BLV, and, in addition, to develop new methods for prevention for these viral pathogenesis. In preparation for the coming threats from newly-emerging viruses, our unit focuses on the development of a new drug targeting a replication mechanism shared by many viruses.

Research Subject

  1. Pathogenesis of HIV-1-induced AIDS and development of anti-HIV-1 strategy
  2. Mechanisms of leukemogeneses by human and bovine leukemia viruses and development of new methods for prevention
  3. Molecular mechanisms of replication of influenza virus and development of new antiviral strategy

Related links

  1. RIKEN Advanced Science Institute Website_Laboratories PageNew Window

List of Selected Publications

  1. Takeda E, Matsuda G, Murakami T, Zako T, Maeda M, Aida Y.:
    "Nuclear Exportin Receptor CAS Regulates the NPI-1-mediated Nuclear Import of HIV-1 Vpr"
    PLOS ONE, 6(11): e27815, 2011
  2. Hebishima T, Tada S., Takeshima S-N, Akaike T, Ito Y, Aida Y.:
    "Induction of antigen-specific cellular and humoral immunity by pH-sensitive carbonate apatite"
    Biochem. Biophys. Res. Commun., 415:597-601, 2011
  3. Miyasaka T., Takeshima S-n., Matsumoto Y., Kobayashi N., Matsuhashi T., Miyazaki Y., Tanabe Y., Ishibashi K., Sentsui S., and Aida Y.:
    "The diversity of bovine MHC class II DRB3 and DQA1 alleles in different herds of Japanese Black and Holstein cattle in Japan"
    J. Dairy Sci., 95:420-31, 2011
  4. Takeshima S, Matsumoto Y, Miyasaka T, Arainga-Ramirez M, Saito H, Onuma M and Aida Y.:
    "A New Method for Typing Bovine Major Histocompatibility Complex Class II DRB3 Alleles by Combining Two Established PCR Sequence-Based Techniques"
    Antigens, 78: 208-213, 2011
  5. Jimba M, Takeshima S, Matoba K, Endoh D and Aida Y.:
    "BLV-CoCoMo-qPCR: Quantitation of bovine leukemia virus proviral load using the CoCoMo algorithm"
    Retorovirology, 7: 91, 2010
  6. Hagiwara K, Murakami T, Xue G, Shimizu Y, Takeda E, Hashimoto Y, Honda K, Kondoh Y, Osada Y and Aida Y.:
    "Identification of a novel Vpr-binding compound that inhibits HIV-1 multiplication in macrophages by chemical array"
    Biophysical Research Communications, 403, 40-45, 2010
  7. Xue G, Aida Y.:
    "Discovery of a Small Molecule Inhibitor of the Interaction Between HIV-1 Proteins nad Cellular Confactors: A Novel Candidate Anti-HIV-1 Drug"
    Current Chemical Biology, 4, 188-199, 2010
  8. Hagiwara K, Kondoh Y, Ueda A, Yamada K, Goto H, Watanabe T, Nakata T, Osada H and Aida Y.:
    "Discovery of novel antiviral agents directed against the influenza A virus nucleoprotein using photo-cross-linked chemical arrays"
    Biochem. Biophys. Res. Commun., 394, 721-727, 2010
  9. Miyasaka T, Takeshima S, Matsumoto Y, Kobayashi N, Matsuhashi T, Miyazaki Y, Tanabe Y, Ishibashi K, Sentsui H and Aida Y.:
    "The diversity of bovine MHC class II DRB3 and DQA1 alleles in different herds of Japanese Black and Holstein cattle in Japan"
    Gene, 472, 42-49, 2010
  10. Suzuki T., Yamamoto N., Nonaka M., Takeshima S., Hashimoto Y., Matsuda G., Matsuyama M., Igarashi T., Miura T., Tanaka R., Kato S., and Aida Y.:
    "Inhibition of human immunodeficiency virus type 1 (HIV-1) nuclear import via Vpr-Importin α interactions as a novel HIV-1 therapy"
    Biochem. Biophys. Res. Commun., 380: 838-843, 2009

Members

Principal Investigator

Yoko AIDA
Unit Leader

Staff Scientist

Shin-nosuke TAKESHIMA
ASI Research Scientist
Michinori KAKISAKA
Collaboration Research from Industry

Postdoctoral Fellow

Yutaka SASAKI
Postdoctoral Researcher
Jiyun KIM
Postdoctoral Researcher
Mayuko JIMBA
Postdoctoral Researcher
Guangai XUE
Visiting Researcher
Hironobu MURAKAMI
Visiting Researcher

Student Trainee

Tomoyuki MURAKAMI
Junior Research Associate
Kazunori YAMADA
Junior Research Associate
Mirai OHASHI
Junior Research Associate

Technical Assistant

Yuki MATSUMOTO
Technical Staff II