Viral Infectious Diseases Unit
Currently, infections account for about 30% of annual mortalities worldwide, and it is feared that the ratio may rise abruptly in the future. This is because new viral infections have recently emerged one after another. One representative of such infections is AIDS, which kills about three million people every year. As well as human immunodeficiency virus type I (HIV-I) is the etiologic agents of AIDS, human T cell leukemia virus type I (HTLV-I) induced adult T-cell leukemia (ATL) and bovine leukemia virus (BLV) induced enzootic bovine leukosis (EBL) constitute a unique subgroup within the retrovirus family. The main subject of our unit is to understand the molecular mechanisms of AIDS induced by HIV-I and leukemogenesis induced by HTLV-I and BLV, and, in addition, to develop new methods for prevention for these viral pathogenesis. In preparation for the coming threats from newly-emerging viruses, our unit focuses on the development of a new drug targeting a replication mechanism shared by many viruses.
- Pathogenesis of HIV-1-induced AIDS and development of anti-HIV-1 strategy
- Mechanisms of leukemogeneses by human and bovine leukemia viruses and development of new methods for prevention
- Molecular mechanisms of replication of influenza virus and development of new antiviral strategy
- Takeda E, Matsuda G, Murakami T, Zako T, Maeda M, Aida Y.:
"Nuclear Exportin Receptor CAS Regulates the NPI-1-mediated Nuclear Import of HIV-1 Vpr"
PLOS ONE, 6(11): e27815, 2011 - Hebishima T, Tada S., Takeshima S-N, Akaike T, Ito Y, Aida Y.:
"Induction of antigen-specific cellular and humoral immunity by pH-sensitive carbonate apatite"
Biochem. Biophys. Res. Commun., 415:597-601, 2011 - Miyasaka T., Takeshima S-n., Matsumoto Y., Kobayashi N., Matsuhashi T., Miyazaki Y., Tanabe Y., Ishibashi K., Sentsui S., and Aida Y.:
"The diversity of bovine MHC class II DRB3 and DQA1 alleles in different herds of Japanese Black and Holstein cattle in Japan"
J. Dairy Sci., 95:420-31, 2011 - Takeshima S, Matsumoto Y, Miyasaka T, Arainga-Ramirez M, Saito H, Onuma M and Aida Y.:
"A New Method for Typing Bovine Major Histocompatibility Complex Class II DRB3 Alleles by Combining Two Established PCR Sequence-Based Techniques"
Antigens, 78: 208-213, 2011 - Jimba M, Takeshima S, Matoba K, Endoh D and Aida Y.:
"BLV-CoCoMo-qPCR: Quantitation of bovine leukemia virus proviral load using the CoCoMo algorithm"
Retorovirology, 7: 91, 2010 - Hagiwara K, Murakami T, Xue G, Shimizu Y, Takeda E, Hashimoto Y, Honda K, Kondoh Y, Osada Y and Aida Y.:
"Identification of a novel Vpr-binding compound that inhibits HIV-1 multiplication in macrophages by chemical array"
Biophysical Research Communications, 403, 40-45, 2010 - Xue G, Aida Y.:
"Discovery of a Small Molecule Inhibitor of the Interaction Between HIV-1 Proteins nad Cellular Confactors: A Novel Candidate Anti-HIV-1 Drug"
Current Chemical Biology, 4, 188-199, 2010 - Hagiwara K, Kondoh Y, Ueda A, Yamada K, Goto H, Watanabe T, Nakata T, Osada H and Aida Y.:
"Discovery of novel antiviral agents directed against the influenza A virus nucleoprotein using photo-cross-linked chemical arrays"
Biochem. Biophys. Res. Commun., 394, 721-727, 2010 - Miyasaka T, Takeshima S, Matsumoto Y, Kobayashi N, Matsuhashi T, Miyazaki Y, Tanabe Y, Ishibashi K, Sentsui H and Aida Y.:
"The diversity of bovine MHC class II DRB3 and DQA1 alleles in different herds of Japanese Black and Holstein cattle in Japan"
Gene, 472, 42-49, 2010 - Suzuki T., Yamamoto N., Nonaka M., Takeshima S., Hashimoto Y., Matsuda G., Matsuyama M., Igarashi T., Miura T., Tanaka R., Kato S., and Aida Y.:
"Inhibition of human immunodeficiency virus type 1 (HIV-1) nuclear import via Vpr-Importin α interactions as a novel HIV-1 therapy"
Biochem. Biophys. Res. Commun., 380: 838-843, 2009
Principal Investigator
- Yoko AIDA
- Unit Leader
Staff Scientist
- Shin-nosuke TAKESHIMA
- ASI Research Scientist
- Michinori KAKISAKA
- Collaboration Research from Industry
Postdoctoral Fellow
- Yutaka SASAKI
- Postdoctoral Researcher
- Jiyun KIM
- Postdoctoral Researcher
- Mayuko JIMBA
- Postdoctoral Researcher
- Guangai XUE
- Visiting Researcher
- Hironobu MURAKAMI
- Visiting Researcher
Student Trainee
- Tomoyuki MURAKAMI
- Junior Research Associate
- Kazunori YAMADA
- Junior Research Associate
- Mirai OHASHI
- Junior Research Associate
Technical Assistant
- Yuki MATSUMOTO
- Technical Staff II

