Laboratories
Laboratory for Vaccine Design
Yasuyuki ISHII
Team Leader
Yasuyuki ISHII (Ph.D.)
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Research Areas

We have been studying about immunoregulatory nano-capsules for the purpose of inducing regulatory dendritic cells (DCreg) and regulatory T cells (Treg) in body. A liposome formulation containing,b,c1d ligand and antigenic protein can induce DCreg and Treg in vivo, and suppress secondary IgE antibody response in an antigen-specific manner. We are going to start research and development of immunoregulatory nanocapsules as one casual immunotherapy for allergic patients.

Research Subject

  1. Research for immunotherapies to allergic diseases by inducing immune tolerance
  2. Research for technologies to manufacture allergy vaccines

Related links

  1. RIKEN Research Center for Allergy and Immunology Website_Laboratories PageNew Window
  2. REGiMMUNE PageNew Window

List of Selected Publications

  1. Ishii Y, Motohashi S, Shimizu K, Nakayama T, Taniguchi M, and Fujii S.:
    "Application of NKT cells in immunotherapy"
    Curr Immunology Rev, 2010, 6, 109-115. ISSN: 1573-3955
  2. Duramad O, Laysang A, Li J, Ishii Y and Namikawa R,:
    "Pharmacologic Expansion of Donor-Derived, Naturally Occurring CD4(+)Foxp3(+) Regulatory T Cells Reduces Acute Graft-versus-Host Disease Lethality Without Abrogating the Graft-versus-Leukemia Effect in Murine Models."
    Biol Blood Marrow Transplant 2010, Dec. 8
  3. Yasuda N, Masuda K, Tsukui T, Teng A, Ishii Y.:
    "Identification of canine natural CD3-positive T cells expressing an invariant T-cell receptor alpha chain."
    Vet Immunol Immunopathol. 2009 Dec 15;132(2-4):224-231
  4. Ishii Y, Nozawa R, Takamoto-Matsui Y, Teng A, Katagiri-Matsumura H, Nishikawa H, Fujita H, Tamura Y, Taniguchi M.:
    "Alpha-galactosylceramide-driven immunotherapy for allergy"
    Front Biosci. May 1;13:6214-6228 (2008)
  5. Tamura Y, Teng A, Nozawa R, Takamoto-Matsui Y, Ishii Y.:
    "Characterization of the immature dendritic cells and cytotoxic cells both expanded after activation of invariant NKT cells with alpha-galactosylceramide in vivo"
    Biochem Biophys Res Commun. May 2;369(2):485-492 (2008)
  6. Tashiro T, Hongo N, Nakagawa R, Seino K, Watarai H, Ishii Y, Taniguchi M, Mori K.:
    "RCAI-17, 22, 24-26, 29, 31, 34-36, 38-40, and 88, the analogs of KRN7000 with a sulfonamide linkage: their synthesis and bioactivity for mouse natural killer T cells to produce Th2-biased cytokines."
    Bioorg Med Chem. 2008 Oct 1;16(19):8896-8906 (2008)
  7. Ito T, Hasegawa A, Hosokawa H, Yamashita M, Motohashi S, Naka T, Okamoto Y, Fujita Y, Ishii Y, Taniguchi M, Yano I, Nakayama T.:
    "Human Th1 differentiation induced by lipoarabinomannan/lipomannan from Mycobacterium bovis BCG Tokyo-172"
    Int Immunol. Jul; 20(7):849-860 (2008)
  8. Fujita S, Yamashita N, Ishii Y, Sato Y, Sato K, Eizumi K, Fukaya T, Nozawa R, Takamoto Y, Yamashita N, Taniguchi M and Sato K.:
    "Regulatory dendritic cells protect against allergic airway inflammation in a murine asthmatic model"
    J Allergy Clin Immunol. Jan;121(1):95-104 (2008)
  9. Hijikata A, Kitamura H, Kimura Y, Yokoyama R, Aiba Y, Bao Y, Fujita S, Hase K, Hori S, Ishii Y, Kanagawa O, Kawamoto H, Kawano K, Koseki H, Kubo M, Kurita-Miki A, Kurosaki T, Masuda K, Nakata M, Oboki K, Ohno H, Okamoto M, Okayama Y, O-Wang J, Saito H, Saito T, Sakuma M, Sato K, Sato K, Seino K, Setoguchi R, Tamura Y, Tanaka M, Taniguchi M, Taniuchi I, Teng A, Watanabe T, Watarai H, Yamasaki S, and Ohara O,:
    "Construction of an open-access database that integrates cross-reference information from the transcriptome and proteome of immune cells"
    Bioinformatics 23:2933-2941 (2007)
  10. Harada M, Magara-Koyanagi K, Watarai H, Nagata Y, Ishii Y, Kojo S, Horiguchi S, Okamoto Y, Nakayama T, Suzuki N, Yeh W-C, Akira S, Kitamura H, Ohara O, Seino K, and Taniguchi M.:
    "IL-21-induced B cell apoptosis mediated by natural killer T cells suppresses IgE responses"
    J. Exp. Med. 203: 2929-2937 (2006)

Members

Principal Investigator

Yasuyuki ISHII
Team Leader

Members

Risa NOZAWA
 
Yoko KAITSU
 
Kaori KUSATSU
 
Hidetoshi AKIMOTO
Visiting Scientist
Emi FUKUDA
Visiting Scientist
Kenichi MASUDA
Visiting Scientist
Hirotake KATO
Visiting Scientist
Toshihito HIRAI
 
Masako IKEMIYAGI
 
Akihiro IWAMATSU