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RIKEN-TORII Joint Research Team
Masaru TANIGUCHI
Team Leader
Masaru TANIGUCHI (M.D., Ph.D.)
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Research Areas

Many Japanese people suffer from Japanese cedar pollinosis in early spring and the increase of the patients has become a severe social problem in Japan. However, the treatment for the pollinosis is mainly symptomatic treatment and curative treatment is not commonly conducted. We are developing a novel vaccine to cure the pollinosis and aim to introduce the vaccine to the Japanese market. Our team is cooperative laboratory with RCAI, RIKEN and TORII Pharmaceutical Co., Ltd. to contribute the social benefit through the development and the future supply of the vaccine to treat Japanese cedar pollinosis.

Research Subject

  1. Production and purification of immunotherapy vaccine for Japanese cedar pollinosis.
  2. To make mouse models of Japanese cedar pollinosis.

List of Selected Publications

  1. Fujimura T., Okamoto Y., Taniguchi M.:
    "Therapeutic effects and biomarkers in sublingual immunotherapy: a review."
    Journal of Allergy. 2012:ArticleID 381737 (2012)
  2. Fujimura T., Yonekura S., Horiguti S., Taniguchi Y., Saito A., Yasueda H., Inamine A., Nakayama T., Takemori T., Taniguchi M., Sakaguchi M., Okamoto Y.
    "Increase of regulatory T cells and the ratio of specific IgE to total IgE are candidates for response monitoring or prognostic biomarkers in two-years sublingual Immunotherapy (SLIT) for Japanese cedar pollinosis."
    Clin. Immunol. 139(1):65-74 (2011)
  3. Fujimura T., Yonekura S., Taniguchi Y., Horiguti S., Saito A., Yasueda H., Nakayama T., Takemori T., Taniguchi M., Sakaguchi M., Okamoto Y.
    "The induced regulatory T cell level, defined as the proportion of IL10+Foxp3+ cells among CD25+CD4+ leukocytes, is a potential therapeutic biomarker for sublingual immunotherapy: a preliminary report."
    Int. Arch. Allergy. Immunol. 153, 378-387 (2010)
  4. Fujimura T. and Okamoto Y.
    "Antigen-specific immunotherapy against allergic rhinitis: the state of the art"
    Allergol. Int. 59, 21-31 (2010)

Members

Principal Investigator

Masaru TANIGUCHI
Team Leader

Members

Takashi FUJIMURA
 
Masao MATSUDA
Visiting Scientist
Hiroyuki MIYAZAKI
Visiting Scientist
Yasushi OKUMURA
Visiting Scientist
Koji FUJINAMI
Visiting Scientist
Ryosuke ISHIKAWA
Visiting Scientist
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