Laboratory for Immune Regulation
Group Director
Masaru TANIGUCHI (M.D., Ph.D.)
Immune system is maintained by the interaction of various lymphocytes with different functions. The dysfunction of the immune system causes various autoimmune diseases such as rheumatoid arthritis, SLE, type I diabetes, systemic sclerosis, and allergic diseases as asthma. Organ transplantation is required to control this immune function to succeed in induction of allograft tolerance. Our lab researches on these important issues in the regulation of immune system.
- To clarify the molecular and cellular mechanisms of regulation of immune responses focus on the NKT cells
- November 17, 2008
- Identification of 'a bad cell' causing respiratory tract hypersensitivity syndromes such as allergic asthma, a strategic target for radical treatment of allergic and inflammatory diseases
- August 13, 2010
- Creating a life-saving killer
Cancer may be kept in check by a method for generating patient-specific immune cells with antitumor activity
- April 30, 2010
- Ever alert for inflammation
Regulatory T cells can travel to and from the skin while controlling immune responses in that organ
- Watarai H, Fujii SI, Yamada D, Rybouchkin A, Sakata S, Nagata Y, Iida-Kobayashi M, Sekine-Kondo E, Shimizu K, Shozaki Y, Sharif J, Matsuda M, Mochiduki S, Hasegawa T, Kitahara G, Endo T, Toyoda T, Ohara O, Harigaya KI, Koseki H, Taniguchi M.:
"Murine induced pluripotent stem cells can be derived from and differentiate into natural killer T cells."
J. Clin. Invest. 120, 2610-2618 (2010). - Watarai H, Rybouchkin A, Hongo N, Nagata Y, Sakata S, Sekine E, Dashtsoodol N, Tashiro T, Fujii SI, Shimizu K, Mori K, Masuda K, Kawamoto H, Koseki H, Taniguchi M.:
"Generation of functional NKT cells in vitro from embryonic stem cells bearing rearranged invariant Vα14-Jα18 TCRα gene."
Blood, 115, 230-237 (2010). - Taniguchi M, Tashiro T, Dashtsoodol N, Hongo N, Watarai H.:
"The specialized iNKT cell system recognizes glycolipid antigens and bridges the innate and acquired immune systems with potential applications for cancer therapy."
Int. Immunol.. 22, 1-6 (2010). - Watarai H, Rybouchkin A, Hongo N, Nagata Y, Sakata S, Sekine E, Dashtsoodol N, Tashiro T, Fujii SI, Shimizu K, Mori K, Masuda K, Kawamoto H, Koseki H, Taniguchi M.:
"Generation of functional NKT cells in vitro from embryonic stem cells bearing rearranged invariant Vα14-Jα18 TCRα gene."
Blood, 115, 230-237 (2010). - Terashima A, Watarai H, Inoue S, Sekine E, Nakagawa R, Hase K, Iwamura C, Nakajima H, Nakayama T, Taniguchi M.:
"A novel subset of mouse NKT cells bearing the IL-17 receptor B responds to IL-25 and contributes to airway hyperreactivity."
J. Exp. Med. 205, 2727-2733 (2008). - Watarai H, Nakagawa R, Omori-Miyake M, Dashtsoodol N, Taniguchi M.:
"Methods for detection, isolation and culture of mouse and human invariant NKT cells."
Nat. Protoc. 3, 70-78 (2008). - Taniguchi M, Harada M, Kojo S, Nakayama T, Wakao H.:
"The regulatory role of Vα14 NKT cells in innate and acquired immune response"
Annu. Rev. Immunol., 21, 483-513 (2003). - Kawano T, Cui J, Koezuka Y, Toura I, Kaneko Y, Motoki K, Ueno H, Nakagawa R, Sato H, Kondo E, Koseki H, Taniguchi M.:
"CD1d-restricted and TCR-mediated activation of Vα14 NKT cells by glycosylceramides."
Science 278, 1626-1629 (1997). - Cui J, Shin T, Kawano T, Sato H, Kondo E, Toura I, Kaneko Y, Koseki H, Kanno M, Taniguchi M.:
"Requirement for Va14 NKT cells in IL-12-mediated rejection of tumors."
Science 278, 1623-1626 (1997).
Principal Investigator
- Masaru TANIGUCHI
- Group Director
Members
- Hiroshi WATARAI
- Michishige HARADA
- Takuya TASHIRO
- Masao SHIOZAKI
- Dashtsoodol NYAMBAYAR
- Sakura SAKATA
- Yuko NAGATA
- Tomokuni SHIGEURA
- Minako AIHARA
- Ritsuko OZAWA
- Kayo NAGATA
- Yue REN
- Sabrina HAMOUCHE
- Kenichiro SEINO
- Visiting Scientist
- Koji MUTEKI
- Visiting Scientist