Laboratory for Transcriptional Regulation
Group Director
Ichiro TANIUCHI
(M.D., Ph.D.)
Transcriptional regulation by a transcription factors network plays central roles in regulating development of multicellular organisms. The aim of our researches in the laborastory for transcriptional regulation is to understand transcriptional regulations that govern genetic programming of lymphocyte development. In particular, we will focus on functions of Runx transcription factor family and mechanisms of silencer-mediated gene repression. Finally, we wish to apply our findings to develop new technology that will be applied to control human diseases.
- Roles of Runx family during immune cell development
- Mechanism of silencer-mediated gene regulation
- September 08, 2008
- Elucidation of the mechanism of differentiation of helper T-cells that govern immunity in thymus
- February 08, 2008
- How cells switch from killers to helpers
Researchers illuminate a pivotal network of closely linked checkpoints controlling the destiny of key immune cells.
- July 24, 2007
- Laboratory for Transcriptional Regulation of RCAI discovered that a transcription factor, Runx, regulates the production of IL-4, a substance associated with the body's allergic response.
- December 16, 2011
- Exploring the mechanism behind the differentiation of immune cells
- December 26, 2008
- Looping-the-loop
A unique model may describe the genetic switch that controls whether a T cell becomes a helper or a killer
- Sakaguchi S, Hombauer M, Bilic I Naoe Y, Schebesta A, Taniuchi I and Ellmeier W
"The zinc finger protein MAZR is part of the transcription factor network controlling CD4/CD8 cell fate decision of DP thymocytes."
Nat. Immunol. 11:442-448 (2010). - Kitoh A, Ono M, Naoe Y, Ohkura N, Yamaguchi T, Yaguchi H, Kitabayashi I, Tsukada T, Nomura T, Miyachi Y, Taniuchi I Sakaguchi S
"Indispensable role of Runx1/Cbfβ complexes for in vivo suppressive function of FoxP3+ regulatory T cells."
Immunity 31:609-620 (2009). - Collins A, Littman D.R, Taniuchi I.
"RUNX proteins in transcription factor networks that regulate T-cell lineage choice."
Nat. Rev. Immunol. 9:106-15 (2009). - Muroi S, Naoe Y, Miyamoto C, Akiyama K, Ikawa T, Masuda K, Kawamoto H and Taniuchi I.
"Cascading suppression of transcriptional silencers by ThPOK seals helper T cell fate."
Nat. Immunol. 9:1113-21 (2008). - Setoguchi R, Tachibana M, Naoe Y, Muroi S, Akiyama K, Tezuka C, Okuda T and Taniuchi I.
"Repression of the Transcription Factor Th-POK by Runx Complexes in Cytotoxic T Cell Development."
Science, 319, 816-819 (2008).
Principal Investigator
- Ichiro TANIUCHI
- Group Director
Members
- Hayato KANEDA
- Taku NAITO
- Mari TENNO
- Hirokazu TANAKA
- Wooseok SEO
- Hisashi WADA
- Sebastian NIEKE
- Risa CHIHARA
- Sawako MUROI
- Mayu OKOSHI
- Shiho NAKAMURA
- Chizuko MIYAMOTO
- Mika IKEGAYA
- Yoshinori NAOE
- Visiting Scientist