Research Unit for Inflammatory Regulation
Unit Leader
Takashi Tanaka (M.D., Ph.D.)
Inflammation is the host defense mechanism to fight against invading microbial pathogens. Inflammatory responses should be tightly regulated, since an excess of these responses can damage normal tissue and may cause autoimmune or allergic diseases. Our research goal is to identify key regulators of inflammation-related signal transduction pathways, and to clarify the molecular mechanisms for regulating inflammatory responses. These studies should contribute to the development of new therapeutic tools to control the exaggerated inflammation seen in certain human diseases. We now focus on the analysis of LIM proteins that negatively regulate inflammatory responses,
- The molecular mechanisms how inflammatory responses are regulated in vivo.
- The role of LIM proteins in innate and adaptive immune systems.
- Tomokazu Matsuda, Yoshiaki Kido, Shun-ichiro Asahara, Tsuneyasu Kaisho, Takashi Tanaka, et al.
"Ablation of C/EBPβ alleviates ER stress and pancreatic βcell failure through the GRP78 chaperone in mice"
J. Clin. Invest. 120, 115-126, 2010 - Yan, P., Fu, J., Qu, Z., Li, S., Tanaka, T., Grusby, M.J., and Xiao, G.
"PDLIM2 suppresses HTLV-I Tax-mediated tumorigenesis by targeting Tax into the nuclear matrix for proteasomal degradation"
Blood, 113, 4370-4380, 2009 - Kaisho, T. and Tanaka, T.
"Turning NF-κB and IRFs on and off in DCs"
Trends Immunol. 29, 329-336, 2008 - Uematsu, S., Kaisho, T., Tanaka, T., Matsumoto, M., Yamakami, M., Omori, H., Yamamoto, M., Yoshimori, T., Akira, S
"The C/EBPβ isoform 34kDa LAP is responsible for NF-IL6-mediated gene induction in activated macrophages, but is not essential for intracellular bacteria killing"
J. Immunol. 179, 5378-5386, 2007 - Tanaka, T. Grusby, M.J. and Kaisho, T.
"PDLIM2-mediated termination of transcription factor NF-κB activation by intranuclear sequestration and degradation of the p65 subunit."
Nat. Immunol. 8, 584-591, 2007 - Nakahira, M., Tanaka, T., Robson, B.E., Mizgerd, J.P. and Grusby, M.J.
"Regulation of Signal Transducer and Activator of Transcription Signaling by the Tyrosine Phosphatase PTP-BL."
Immunity 26, 163-176, 2007 - Hoshino. K., Sugiyama, T., Matsumoto, M., Tanaka, T., Saito, M., Hemmi, H., Ohara, O., Akira, S., and Kaisho, T.
"IκB kinase-α is critical for interferon-α production induced by Toll-like receptors 7 and 9."
Nature 440, 949-953, 2006 - Tanaka, T., Soriano, M.A. and Grusby, M.J.
"SLIM is a nuclear ubiquitin ligase that negatively regulates STAT signaling."
Immunity, 22, 729-736, 2005
Principal Investigator
- Takashi TANAKA
- Unit Leader
Members
- Masanaka SUGIYAMA
- Emiri HAGA
- Tsuneyasu KAISHO
- Senior Visiting Scientist
- Katsuaki HOSHINO
- Visiting Scientist
- Hiroaki HENMI
- Visiting Scientist