Laboratory for Infectious Immunity
Team Leader
Satoshi ISHIDO
(M.D.,Ph.D.)
We are focusing on a novel family of E3 ubiquitin ligases (E3s) that function as an immunosuppressor. These molecules have been classified into two groups: viral E3s and mammalian E3s. Interestingly, these E3s target a different set of antigen presentation-related molecules such as MHC class I, B7, ICAM-1. However, the molecular mechanisms for specific targeting and a physiological function of mammalian E3s are still unknown. We are exploring a new paradigm in immunoregulation and a novel immunotherapy by investigating a molecular and physiological function of a novel class of E3 ubiquitin ligases.
- Molecular mechanism on specific recognition by a novel E3 family
- Physiological function of a novel E3 family
- Establishment of a novel immunosuppressive therapy using immunosuppressive E3s
- Goto, E., Yamanaka, Y., Ishikawa, A., Aoki-Kawasumi, M., Mito-Yoshida, M., Ohmura-Hoshino, M., Matsuki, Y., Kajikawa, M., Hirano, H., and Ishido, S
"Contribution of K11-linked ubiquitination to MIR2-mediated MHC class I internalization."
J Biol Chem. 2010 Nov;285(46):35311-9. Epub 2010 Sep 10. - Walseng, E., Furuta, K., Bosch, B., Weih, KA., Matsuki, Y., Bakke, O., Ishido, S., and Roche, PA.
"Ubiquitination Regulates MHC Class II-Peptide Complex Retention and Degradation in Dendritic Cells."
Proc. Natl. Acad. Sci. U S A. 2010 Nov;107(47):20465-70. Epub 2010 Nov 8 - Ishido, S., Matsuki, Y., Goto, E., Kajikawa, M., Ohmura-Hoshino, M.
"MARCH-I: a new regulator of dendritic cell function."
Mol Cells. 2010 Mar;29(3):229-32. Epub 2010 Mar 4. - Ohmura-Hoshino M, Matsuki Y, Mito-Yoshida M, Goto E, Aoki-Kawasumi M, Nakayama M, Ohara O, Ishido S.
"Requirement of MARCH-I-mediated MHC II ubiquitination for the maintenance of conventional dendritic cells."
J Immunol. 2009 Dec 1;183(11):6893-7. Epub 2009 Nov 16. - Goto, E., Mito-Yoshida, M., Uematsu, M., Aoki, M., Matsuki, Y., Ohmura-Hoshino, M., Hotta, H., Miyagishi, M. and Ishido, S.
"An excellent monitoring system for surface ubiquitination-induced internalization in mammals."
PLoS ONE. 2008 Jan 30;3(1):e1490. - Matsuki, Y., Ohmura-Hoshino, M., Goto E., Aoki M., Mito-Yoshida M., Uematsu M., Hasegawa T., Koseki H., Ohara O., Nakayama M., Toyooka K., Matsuoka K., Hotta H., Yamamoto A. and Ishido,S.
"Novel regulation of MHC class II function in B cells"
EMBO J. 2007 Feb.7; 26(3);846-854;Epub. 2007 Jan 25, - Ohmura-Hoshino, M., Goto,E., Matsuki,Y., Aoki,M., Mito,M., Uematsu,M., Hotta, H. and Ishido, S.
"A novel family of membrane-bound E3 ubiquitin ligases."
J. Biochem. (Tokyo) 2006 Aug; 140(2): 147-54. - Yonashiro, R., Ishido,S., Kyo,S., Fukuda,T., Goto,E., Matsuki,Y., Ohmura-Hoshino,M., Sada,K., Hotta,H., Yamamura,H., Inatome,R. and Yanagi, S.
"A novel mitochondrial ubiquitin ligase plays a critical role in mitochondrial dynamics."
EMBO J. 2006 Aug 9; 25(15): 3618-26. Epub. 2006 Jul 27. - Ohmura-Hoshino, M., Matsuki, Y., Aoki,M., Goto, E., Mito, M., M. Uematsu,, Kakiuchi, T., Hotta, H. and Ishido, S.
"Inhibition of MHC class II expression and immune responses by c-MIR1"
J. Immunol. 2006 Jul 1; 177(1): 341-54. - Uchida, D., Hatakeyama, S., Matsushima, A., Han, H., Ishido, S., Hotta, H., Kudoh, J., Shimizu, N., Doucas, V., Nakayama, KI., Kuroda, N. and Matsumoto, M.
"Related Articles, Links AIRE functions as an E3 ubiquitin ligase."
J Exp. Med. 19,199(2):167-72., 2004
Principal Investigator
- Satoshi ISHIDO
- Team Leader
Members
- Mari HOSHINO
- Eiji GOTO
- Mizuho KAJIKAWA
- Pai-Chi LI
- Rikiya ISHIKAWA
- Mari MITO
- Masami AOKI
- Naoko TACHIBANA