Laboratory for Immunogenetics
Team Leader
Hisahiro YOSHIDA
(M.D., Ph.D.)
Disruption of the immune system sometimes results in the attack against self tissue or irritation with too strong immune response. They are the autoimmune disease like rheumatoid arthritis or SLE, or allergic disease like pollinosis. The cause of such a disease is thought to be a combination of the environmental and genetic disorders. We are screening the ENU induced mutant mice stock to find out the auto-immune or allergic disease model animals by means of phenotype analysis. After establishment of specific mutant lines, we will detect the mutant loci and clarify the function of the gene product in immune system to find out the way to cure human allergic or immunologic disease under the light of mutant analysis. Recently, we have screened 8000 mice from 84 pedigree, and responsible loci mapping is underway. In topic,we have succeeded to clarify the mechanism of atopic dermatitis development and to prevent the disease onset under the light of our findings by using an AD model mouse line.
- Establishment of immune disease model in ENU induced mutant mice
- Investigation of peripheral lymphoid organ development
- Study on atopic dermatitis development and its treatment
- August 28, 2009
- New gene themis identified that is indispensable for T-cell maturation
- Tachibana M, Tenno M, Tezuka C, Sugiyama M, Yoshida H, Taniuchi I.:
"Runx1/Cbf β2 complexes are required for lymphoid tissue inducer cell differentiation at two developmental stages."
J Immunol. 186(3):1450-7 (2011) - Yoshibumi Matsushima, Yoshiaki Kikkawa, Toyoyuki Takada, Kunie Matsuoka, Yuta Seki, Hisahiro Yoshida, Yoshiyuki Minegishi, Hajime Karasuyama, and Hiromichi Yonekawa.:
"An Atopic Dermatitis-Like Skin Disease with Hyper-IgE-Emia Develops in Mice Carrying a Spontaneous Recessive Point Mutation in the Traf3ip2 (Act1/CIKS) Gene."
J Immunol. 185(4),2340-9 (2010) - Nabeyama A, Kurita A, Asano K, Miyake Y, Yasuda T, Miura I, Nishitai G, Arakawa S, Shimizu S, Wakana S, Yoshida H, Tanaka M.:
"xCT deficiency accelerates chemically induced tumorigenesis."
Proc Natl Acad Sci U S A. 107(14),6436-41.(2010) - Wada H., Yasuda T., Miura I., Watabe K., Sawa C., Kamijuku H., Kojo S., Taniguchi M., Nishino I., Wakana S., Yoshida H., Seino K.
"Establishment of an improved mouse model for infantile neuroaxonal dystrophy that shows early disease onset and bears a point mutation in Pla2g6"
Am J Pathol. 175(6), 2257-63 (2009) - Kakugawa K., Yasuda T., Miura I., Kobayashi A., Fukiage H., Satoh R., Matsuda M., Koseki H., Wakana S., Kawamoto H., Yoshida H.:
"A novel gene essential for the development of single positive thymocytes"
Mol Cell Biol. 29(18), 5128-35. (2009) - Aoki H. ,Yoshida H. ,Hara A. ,Suzuki T. ,and Kunisada T.:
"Transplantation of melanocytes into iris: method for iris repigmentation."
Transplantation. 85, 492-494 (2008) - Hamanaka S., Nabekura T., Otsu M., Yoshida H., Nagata M., Usui J., Takahashi S., Nagasawa T., Nakauchi H., Onodera M.:
"Stable transgene expression in mice generated from retrovirally transduced embryonic stem cells."
Mol Ther. 15(3),560-5(2007) - Piao JH., Yoshida H., Yeh WC., Doi T., Xue X., Yagita H., Okumura K., Nakano H.:
"TNF receptor-associated factor 2-dependent canonical pathway is crucial for the development of Peyer's patches."
J Immunol. 178(4),2272-7(2007) - Sato T., Endoh M., Yoshida H., Yasuo S., Katsuno T., Saito Y., Isono K., Koseki H. Mammalian Polycomb:
"Mammalian Polycomb complexes are required for Peyer's patch development by regulating lymphoid cell proliferation."
Gene. 379, 166-74(2006) - Tosaki H,Kunisada T.,Motohashi T.,Aoki H.,Yoshida H.,Kitajima Y.:
"Mice Transgenic for KitV620A:Recapitulation of Piebaldism but not Progressive Depigmentation Seen in Humans with this Mutation."
J Invest Dermato. 126, 1111-1118(2006)
Principal Investigator
- Hisahiro YOSHIDA
- Team Leader
Members
- Takuwa YASUDA
- Akimi BANNO
- Ayako KOBAYASHI
- Hitomi FUKIAGE
- Takehiro URA
- Visiting Scientist
- Mikiko SATOH
- Takeyuki GOTOU