Laboratory for Immunogenomics

Group Director
Osamu OHARA (Ph.D.)
We construct a wide variety of platforms for transcriptomic and proteomic analyses to obtain a comprehensive understanding of various immunological events on the genomic basis. Fully exploiting the accumulated genomic resources and various biophysical technologies, we will make it possible to comprehensively describe cellular events of various immunological diseases in molecular terms.
- Analysis of post-transcriptional regulation of gene expression in immune cells
- Technical development for proteomic and transcriptomic analyses of the immune system
- Construction of immunogenomics reference database
- Analysis of primary immunodeficiency diseases
- February 04, 2010
- Molecular target identified in leukemia stem cell that causes regeneration of acute myeloid leukemia
- Kimura Y, Nagata K, Suzuki N, Yokoyama R, Yamanaka Y, Kitamura H, Hirano H, Ohara O.:
"Characterization of multiple alternative forms of heterogeneous nuclear ribonucleoprotein K by phosphor-affinity electrophoresis."
Proteomics. 10, 3884-3895 (2010) - Watarai H, Fujii SI., Yamada D, Rybouchkin A, Sakata S, et al.:
"Murine induced pluripotent stem cells can be derived from and differentiate into natural killer T cells."
J Clin Invest. 120, 2610-2618 (2010) - Saito Y, Kitamura H, Hijikata A, Tomizawa-Murasawa M, Tanaka S, et al.:
"Identification of therapeutic targets for quiescent, chemotherapy-resistant human leukemia stem cells."
Sci Transl Med. 2, 17ra19 (2010) - Hijikata A, Raju R, Keerthikumar S, Ramabadran S, Balakrishnan L, et al.:
"Mutation@A Glance: An Integrative Web Application for Analysing Mutations from Human Genetic Diseases."
DNA Res 17, 197-208 (2010) - Ohmura-Hoshino M, Matsuki Y, Mito-Yoshida M, Goto E, Aoki-Kawasumi M, et al.:
"Cutting edge: requirement of MARCH-I-mediated MHC II ubiquitination for the maintenance of conventional dendritic cells."
J Immunol. 183, 6893-7 (2009) - Kitajima M, Iwamura C, Miki-Hosokawa T, Shinoda K, Endo Y, et al.:
"Enhanced Th2 cell differentiation and allergen-induced airway inflammation in Zfp35-deficient mice."
J Immunol. 183, 5388-96 (2009) - Okamoto, M. et al.:
"Mina, an Il4 repressor, controls T helper type 2 bias."
Nat Immunol. 10, 872-9 (2009) - Ohara O.:
"From transcriptome analysis to immunogenomics: current status and future direction."
FEBS Lett. 583, 1662-7 (2009) - Keerthikumar S, Raju R, Kandasamy K, Hijikata A, Ramabadran S, Balakrishnan L, et al.:
"Resource of Asian Primary Immunodeficiency Diseases."
Nucleic Acids Res. 37, D863-867 (2009) - Fukada T, Civic N, Furuichi T, Shimoda S, Mishima K, Higashiyama H, Idaira Y, Asada Y, Kitamura H, et al.:
"The zinc transporter SLC39A13/ZIP13 is required for connective tissue development; its involvement in BMP/TGF-beta signaling pathways."
PLoS ONE 3, e3642 (2008)
Principal Investigator
- Osamu OHARA
- Group Director
Members
- Shinji NAKAOKA
- Yoko KUROKI
- Takashi WATANABE
- Atsushi HIJIKATA
- Mai SHIRASAKI
- Yoshitaka SHIRASAKI
- Asahi NAKAHARA
- Masayuki ISHII
- Nanako SHIMURA
- Keiko TATENO
- Naomi INAGAKI
- Tomoko HASEGAWA
- Nobutake SUZUKI
- Ritsuko OZAWA
- Atsuo KOBAYASHI
- Yoshinori HASEGAWA
- Visiting Scientist
- Yoshiharu YAMAMOTO
- Visiting Scientist
- Kazuyuki AIHARA
- Visiting Scientist
- Kenko UCHIDA
- Visiting Scientist
- Koji TSUMURA
- Visiting Scientist
- Shinji HARA
- Visiting Scientist
- Junichi IMURA
- Visiting Scientist
- Ken NONAKA
- Visiting Scientist
- Emi ABE
- Noriko UTSUMI
- Fumie YOKOYAMA
- Nobuyuki GOTO