Laboratories
Laboratory for Immunochaperones
Heiichiro UDONO
Team Leader
Heiichiro UDONO
(M.D.,Ph.D.)
mail

Research Areas

Our team proposes to call intracellular molecular chaperones as immunochaperones when they are playing roles in a variety of immune response. We examine novel functions of these immunochaperones in immunity. Particularly we focus on those in antigen processing linked with protein degradation by ubiquitin-proteasome system, and in activation of innate and acquired immunity. Besides, unpredictable observation associated with chaperones found in ongoing experiments will drive us to dig those up to construct a new paradigm of a world of molecular chaperones in immunity and life science.

Research Subject

  1. Analysis of molecular mechanism of hsp90 in MHC class I antigen processing
  2. Functional analysis of molecular chaperones in antigen cross-presentation

Related links

  1. RIKEN Research Center for Allergy and Immunology Website_Laboratories PageNew Window

List of Selected Publications

  1. Ichiyanagi T, Imai T, Kajiwara C, Mizukami S, Nakai A, Nakayama T, Udono, H:
    "Essential role of endogenous HSP90 of dendritic cells in antigen cross-presentation."
    J. Immunol. 185, 2693-2700 (2010)
  2. Udono H, Ichiyanagi T, Mizukami S, Imai T:
    "Heat shock proteins in antigen trafficking - Implications on antigen presentation to T cells -"
    International Journal of Hyperthermia 25, 617-625 (2009).
  3. Yamano, T, Mizukami S, Murata S, Chiba T, Tanaka K, Udono, H:
    "Hsp90 mediated assembly of the 26S proteasome is involved in major histocompatibility complex class I antigen processing"
    J. Biol.Chem. 283, 28060-28065 (2008)
  4. Yamano, T, Sugahara H, Mizukami S, Murata S, Chiba T, Tanaka K, Yui, K, Udono, H:
    "Allele-selective effect of PA28 in major histocompatibility complex class I antigen processing"
    J. Immunol., 181, 1655-1664 (2008).
  5. Mizukami S, Kajiwara C, Ishikawa H, Katayama I, Yui K, Udono H.
    "Both CD4+ and CD8+ T cell epitopes fused to heat shock cognate protein 70 (hsc70) can function to eradicate tumors"
    Cancer Science, 99, 1008-1015 (2008).
  6. Honma, K., Udono, H., Kohno, T., Yamamoto, K., Ogawa, A., Takemori, T., Kumatori, A., Suzuki, S., Matsuyama, T., and Yui, K.:
    "Interferon regulatory factor-4 negatively regulates the production of proinflammatory cytokines by macrophages in response to LPS."
    Proc. Natl Acad. Sci. USA., 102, 16001-16006 (2005).
  7. Furukawa, H., Doh-ura, K., Okuwaki, R., Shirabe, S., Yamamoto, K., Udono, H., Ito, T., Katamine, S., and Niwa, M.:
    "A Pitfall in Diagnosis of Human Prion Diseases Using Detection of Protease-resistant Prion Protein in Urine. CONTAMINATION WITH BACTERIAL OUTER MEMBRANE PROTEINS"
    J. Biol. Chem., 279, 23661-23667 (2004).
  8. Ohkusu-Tsukada, K., Tominaga, N., Udono, H., and Yui, K.:
    "Regulation of the Maintenance of Peripheral T-Cell Anergy by TAB1-Mediated p38 Activation"
    Mol. Cell. Biol., 24, 6957-6966 (2004).
  9. Yamano, T., Murata, S., Shimbara, N., Tanaka, N., Chiba, T., Tanaka, K., Yui, K., and Udono, H.:
    "Two distinct pathway mediated by PA28 and hsp90 in major histocompatibility complex class I antigen processing"
    J. Exp. Med., 196, 185-196 (2002).
  10. Murata, S., Udono, H., Tanahashi, N., Hamada, N., Watanabe, K., Adachi, K., Yamano, T., Yui, K., Kobayashi, N., Kasahara, M., Tanaka, K., and Chiba, T.:
    "Immunoproteasome assembly and antigen presentation in mice lacking both PA28α and PA28"
    EMBO J., 20, 5898-5907 (2001).

Members

Principal Investigator

Heiichiro UDONO
Team Leader

Members

Shizuha UDA
 
Yu KATO
 
Takashi MATSUURA
 
Chiaki KAJIWARA
 
Shusaku MIZUKAMI
Visiting Scientist