Research Unit for Cellular Immunotherapy

Unit Leader
Shin-ichiro FUJII
(M.D., Ph.D.)
In our basic studies, we focus on the link between innate immunity and acquired immunity, especially dendritic cell and NKT cell interaction. The final goal of our team is to extend the basic study for advancing immunotherapy and the translational research, from basic studies back and forth to the bed side in the field of cancer and the control of transplantation.
- Cellular immunotherapy against cancers
- Evaluation of roles of dendritic cells (DCs) in induction of adaptive immunity
- Analyses of immune responses in leukemia patients and development for immunotherapy
- Translational research for cancer
- Fujii S, Motohashi S, Shimizu K, Nakayama T, Yoshiga Y, and Taniguchi M
"Aduvant activity mediated by iNKT cells"
Semin Immunol, 22, 97-102 (2010) - Fujii S, Takayama T, Asakura M, Aki K, Fujimoto K, and Shimizu K.
"Dendritic cell-based cancer immunotherapies."
Arch Immunol Ther Exp., 57, 189-198 (2009) - Fujii S, Goto A, and Shimizu K.
"Antigen mRNA-transfected, allogeneic fibroblasts loaded with NKT cell ligand confer antitumor immunity"
Blood, 113, 4262-4272 (2009) - Shimizu K, and Fujii S.
"DC therapy induces long-term NK reactivity to tumors via host DC"
Eur J. Immunol., 39, 457-468 (2009) - Shimizu K, and Fujii S.
"An adjuvant role of in situ dendritic cells (DCs) in linking innate and adaptive immunity."
Front in Bioscience., 13, 6193-6201 (2008) - Fujii S.
"Exploiting dendritic cells (DCs) and NKT cells in immunotherapy against malignancies."
Trends Immunol., 29, 242-249 (2007) - Fujii S, Shimizu K, Hemmi H, and Steinman RM.
"Innate Va14+natural killer T cells mature dendritic cells, leading to strong adaptive immunity."
Immunological Rev., 220, 183-198 (2007) - Shimizu K, Kurosawa Y, Taniguchi M, Steinman RM, and Fujii S.
"Cross-presentation of glycolipid from tumor cells loaded with alpha-galactosylceramide leads to potent and long-lived T cell mediated immunity via dendritic cells."
J Exp Med., 204, 2641-2653 (2007). - Shimizu K, Goto A, Fukui M, Taniguchi M, and Fujii S.
"Tumor cells loaded with a-GalCer induce innate NKT and NK cell-dependent resistance-tumor implantation in mice."
J Immunol., 178, 2853-2861 (2007). - Shimizu K., Hidaka M, Kadowaki N, Makita N, Konishi N, Fujimoto K., Uchiyama T, Kawano F, Taniguchi M, and Fujii S.
"Evaluation of the function of human invariant NKT cells from cancer patients using a-GalCer-loaded murine dendritic cells."
J Immunol., 177, 3484-3492 (2006).
Principal Investigator
- Shin-ichiro FUJII
- Unit Leader
Members
- Jun SHINGA
- Miki ASAKURA
- Hidetoshi SUGAHARA
- Yusuke SATO