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Research Unit for Cellular Immunotherapy
Shin-ichiro FUJII
Unit Leader
Shin-ichiro FUJII
(M.D., Ph.D.)
mail

Research Areas

In our basic studies, we focus on the link between innate immunity and acquired immunity, especially dendritic cell and NKT cell interaction. The final goal of our team is to extend the basic study for advancing immunotherapy and the translational research, from basic studies back and forth to the bed side in the field of cancer and the control of transplantation.

Research Subject

  1. Cellular immunotherapy against cancers
  2. Evaluation of roles of dendritic cells (DCs) in induction of adaptive immunity
  3. Analyses of immune responses in leukemia patients and development for immunotherapy
  4. Translational research for cancer

Related links

  1. RIKEN Research Center for Allergy and Immunology Website_Laboratories PageNew Window

Press release

October 23, 2007
Unmasking and killing resistant tumors
Scientists at RIKEN improve an experimental therapy that harnesses the immune system to circumvent tumor resistanceNew Window

RIKEN RESEARCH

January 18, 2008
On the road to a vaccine against tumors
Researchers find how to generate an immune response in miceNew Window
September 22, 2006
Understanding optimized immune therapy
A single agent efficiently activates multiple arms of the immune responseNew Window

List of Selected Publications

  1. Fujii S, Motohashi S, Shimizu K, Nakayama T, Yoshiga Y, and Taniguchi M
    "Aduvant activity mediated by iNKT cells"
    Semin Immunol, 22, 97-102 (2010)
  2. Fujii S, Takayama T, Asakura M, Aki K, Fujimoto K, and Shimizu K.
    "Dendritic cell-based cancer immunotherapies."
    Arch Immunol Ther Exp., 57, 189-198 (2009)
  3. Fujii S, Goto A, and Shimizu K.
    "Antigen mRNA-transfected, allogeneic fibroblasts loaded with NKT cell ligand confer antitumor immunity"
    Blood, 113, 4262-4272 (2009)
  4. Shimizu K, and Fujii S.
    "DC therapy induces long-term NK reactivity to tumors via host DC"
    Eur J. Immunol., 39, 457-468 (2009)
  5. Shimizu K, and Fujii S.
    "An adjuvant role of in situ dendritic cells (DCs) in linking innate and adaptive immunity."
    Front in Bioscience., 13, 6193-6201 (2008)
  6. Fujii S.
    "Exploiting dendritic cells (DCs) and NKT cells in immunotherapy against malignancies."
    Trends Immunol., 29, 242-249 (2007)
  7. Fujii S, Shimizu K, Hemmi H, and Steinman RM.
    "Innate Va14+natural killer T cells mature dendritic cells, leading to strong adaptive immunity."
    Immunological Rev., 220, 183-198 (2007)
  8. Shimizu K, Kurosawa Y, Taniguchi M, Steinman RM, and Fujii S.
    "Cross-presentation of glycolipid from tumor cells loaded with alpha-galactosylceramide leads to potent and long-lived T cell mediated immunity via dendritic cells."
    J Exp Med., 204, 2641-2653 (2007).
  9. Shimizu K, Goto A, Fukui M, Taniguchi M, and Fujii S.
    "Tumor cells loaded with a-GalCer induce innate NKT and NK cell-dependent resistance-tumor implantation in mice."
    J Immunol., 178, 2853-2861 (2007).
  10. Shimizu K., Hidaka M, Kadowaki N, Makita N, Konishi N, Fujimoto K., Uchiyama T, Kawano F, Taniguchi M, and Fujii S.
    "Evaluation of the function of human invariant NKT cells from cancer patients using a-GalCer-loaded murine dendritic cells."
    J Immunol., 177, 3484-3492 (2006).

Members

Principal Investigator

Shin-ichiro FUJII
Unit Leader

Members

Jun SHINGA
 
Miki ASAKURA
 
Hidetoshi SUGAHARA
 
Yusuke SATO