Laboratory for Dendritic Cell Immunobiology
Team Leader
Katsuaki SATO (Ph.D.)
Dendritic cells (DCs) are a heterogeneous group of antigen-presenting cells (APCs) with two major subsets, conventional DCs (cDCs) and plasmacytoid DCs (pDCs). In vitro and ex vivo observations suggest that DCs play a crucial role in the link between innate and adaptive immunity under inflammatory conditions but also induce immunological tolerance to maintain immune homeostasis under steady-state conditions. However, it remains unclear how each DC subset controls immune response in vivo. Our goal is to clarify the role of murine DC subsets in the immune system in vivo and to identify the molecular basis for the regulation of their function.
- Analysis of the role of murine dendritic cell subsets in the immune system in vivo
- Analysis of the molecular basis for the regulation of function of murine dendritic cell subsets
- Development of immunotherapy focusing on dendritic cells for immune disorders
- May 07, 2009
- Mechanism discovered that prevents immunological rejection in the transplantation of organs such as hematopoietic stem cells: First ever proof of control mechanisms for graft-versus-host disease in mice
- Fukaya, T., Takagi, H., Sato, Y., Sato, K., Eizumi, K., Taya, H., Shin, T., Chen, L., Dong, C., Azuma, M., Yagita, H., Malissen, B. and Sato, K.
"Crucial roles of B7-H1 and B7-DC expressed on mesenteric lymph node dendritic cells in the generation of antigen-specific CD4+Foxp3+regulatory T cells in the establishment of oral tolerance."
Blood, 116, 2266-2276 (2010). - Sato, K., Eizumi, K., Fukaya, T., Fujita, S., Sato, Y., Takagi, H., Yamamoto, M., Yamashita, N., Hijikata, A., Kitamura, H., Ohara, O., Yamasaki, S., Saito, T. and Sato, K.:
"Naturally occurring regulatory dendritic cells regulate murine cutaneous chronic graft-versus-host disease."
Blood, 113, 4780-4789 (2009). - Fujita, S., Sato, Y., Sato, K., Eizumi, K., Fukaya, T., Kubo, M., Yamashita, N. and Sato, K.:
"Regulatory dendritic cells protect against cutaneous chronic graft-versus-host disease mediated through CD4+CD25+Foxp3+T cells."
Blood, 110, 3793-3803 (2007). - Sato, K. and Fujita, S.:
"Dendritic cells-Nature and classification."
Allergol. Int., 56, 183-191 (2007). - Matsumura, Y., Kobayashi, T., Ichiyama, K., Yoshida, R., Hashimoto, M., Takimoto, T., Tanaka, K., Chinen, T., Shichita, T., Wyss-Coray, T., Sato, K. and Yoshimura, A.:
"Selective expansion of Foxp3-positive regulatory T cells and immunosuppression by SOCS3-deficient dendritic cells."
J. Immunol., 179, 2170-2179 (2007) - Fujita, S., Seino, K., Sato, K., Sato, Y., Eizumi, K., Yamashita, N., Taniguchi, M. and Sato, K.:
"Regulatory dendritic cells act as regulators of acute lethal systemic inflammatory response."
Blood, 107, 3656-3664 (2006). - Sato, K., Nakaoka, T., Yamashita, N., Yagita, H., Kawasaki, H., Morimoto, C., Baba, M. and Matsuyama, T.:
"TRAIL-transduced dendritic cells protect mice from acute graft-versus-host disease and leukemia relapse"
J. Immunol., 174, 4025-4033 (2005). - Sato, K., Yamashita, N., Yamashita, N., Baba, M., and Matsuyama, T.:
"Regulatory dendritic cells protect mice from murine acute graft-versus-host disease and leukemia relapse"
Immunity, 18, 367-379 (2003). - Sato, K., Yamashita, N., Baba, M. and Matsuyama, T.:
"Modified myeloid dendritic cells act as regulatory dendritic cells to induce anergic and regulatory T cells"
Blood, 101, 3581-3589 (2003).
Principal Investigator
- Katsuaki SATO
- Team Leader
Members
- Hideaki TAKAGI
- Kaori SATO
- Yumiko SATO
- Azusa SHIBAZAKI
- Haruna OTSUKA
- Takeshi HOSOI
- Visiting Scientist