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Laboratory for Developmental Dynamics
Shuichi ONAMI
Team Leader
Shuichi ONAMI (D.V.M.,Ph.D.)
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Research Areas

Development of multicellular organism is a spatially and temporally dynamic process. A single cell, the fertilized egg, divides many times to generate many functionally different cells, each of which is brought to a specific position to produce complex multicellular structures, i.e. organs and the body. An effective approach to such spatially and temporally dynamic processes is quantitative and computational approach, which combines quantification, modeling and computer simulation. To understand the mechanism of development of multicellular organisms, we are developing mathematical models of developmental systems, such as C. elegans embryo, mouse embryo and three-dimensional cell culture system, by combining molecular cell biology, biophysics, genome science, computational science and mathematical science.

Research Subject

  1. System analysis of development by using large collections of quantitative dynamic information
  2. Mathematical modeling of development
  3. Development of technology for measuring developmental dynamics

Related links

  1. RIKEN Quantitative Biology Center Website_Laboratories PageNew Window
  2. Individual Website Laboratory PageNew Window

List of Selected Publications

  1. Kimura, A., Onami, S.:
    "Modeling microtubuel-mediated forces and centrosome positioning in Caenorhabditis elegans embryos"
    Methods Cell Biol., 97, 437-453 (2010)
  2. Hamahashi, S., Kitano, H., Onami, S.:
    "A system for measuring cell division patterns of early Caenorhabditis elegans embryos by using image processing and object tracking"
    Systems Comput. Jpn., 38(11), 12-24 (2007)
  3. Kimura, A., Onami, S.:
    "Local cortical pulling force repression switches centrosomal centration and posterior displacement in C. elegans"
    J. Cell Biol., 179, 1347-1354 (2007)
  4. Hamahashi, S., Onami, S., Kitano, H.:
    "Detection of nuclei in 4D Nomarski DIC microscope images of early Caenorhabditis elegans embryos using local image entropy and object tracking"
    BMC Bioinformatics 6, 125 (2005)
  5. Kimura, A., Onami, S.:
    "Computer simulations and image processing reveal length-dependent pulling force as the primary mechanism for C. elegans male pronuclear migration"
    Dev. Cell 8, 765-775 (2005)

Members

Principal Investigator

Shuichi ONAMI
Team Leader

Members

Koji KYODA
Research Scientist
Masashi FUJITA
Postdoctoral Researcher
Jun TAKAYAMA
Postdoctoral Researcher
Yusuke AZUMA
Postdoctoral Researcher
Hatsumi OKADA
Technical Staff I
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