LSA System Development Group

Project Director
Jun KAWAI (Ph.D.)
LSA System Development Group aims at schematization of variety of genome-wide technologies to establishing the 'Life Science Accelerator (LSA)', which is a versatile system for elucidating molecular network. The research group collaborates strongly with the other gruops in the Omics Science Center. Especially, we standardize the technologies that are developed by the LSA Technology Development Group to apply them to the large-scale data generation system.
The group widely provides the accumulated technololgies for transcriptome analysis utilizing the next-generation sequencers to the industry, academia and government as a service system 'GeNAS (Genome Network Analysis Service)'.
- Genome Science
- Molecular Biology
- Ravasi T, Suzuki H, Cannistraci CV, Katayama S, Bajic VB, Tan K, Akalin A, Schmeier S, Kanamori-Katayama M, Bertin N, Carninci P, Daub CO, Forrest AR, Gough J, Grimmond S, Han JH, Hashimoto T, Hide W, Hofmann O, Kamburov A, Kaur M, Kawaji H, Kubosaki A, Lassmann T, van Nimwegen E, MacPherson CR, Ogawa C, Radovanovic A, Schwartz A, Teasdale RD, Tegnér J, Lenhard B, Teichmann SA, Arakawa T, Ninomiya N, Murakami K, Tagami M, Fukuda S, Imamura K, Kai C, Ishihara R, Kitazume Y, Kawai J, Hume DA, Ideker T, Hayashizaki Y.:
"An atlas of combinatorial transcriptional regulation in mouse and man."
Cell. 140(5):744-752 (2010) - H Suzuki, A Forrest, E van Nimwegen, CO Daub, P Balwierz, KM Irvine, T Lassmann, T Ravasi, Y Hasegawa, MJ De Hoon, S Katayama, K Schroder, P Carninci, Y Tomaru, M Kanamori, A Kubosaki, A Akalin, Y Ando, E Arner, M Asada, H Asahara, T Bailey, VB Bajic, D B.:
"The transcriptional network that controls growth arrest and differentiation in a human myeloid leukemia cell line"
Nature Genetics, 41 (5), 553-562 (2009) - A Kubosaki, Y Tomaru, M Tagami, E Arner, H Miura, T Suzuki, M Suzuki, H Suzuki, Y Hayashizaki,:
"Genome-wide investigation of in vivo EGR-1 binding sites in monocytic differentiation"
Genome Biology, 10 (R41), 1-14 (2009) - GJ Faulkner, Y Kimura, CO Daub, S Wani, C Plessy, KM Irvine, K Schroder, N Cloonan, AL Steptoe, T Lassmann, K Waki, N Hornig, T Arakawa, H Takahashi, J Kawai, A Forrest, H Suzuki, Y Hayashizaki, DA Hume, V Orlando, S Grimmond, P Carninci,:
"The regulated retrotransposon transcriptome of mammalian cells"
Nat Genet, 41(5), 563-571 (2009) - RJ Taft, E Glazov, N Cloonan, C Simons, S Stephen, GJ Faulkner, T Lassmann, A Forrest, S Grimmond, K Schroder, KM Irvine, T Arakawa, M Nakamura, A Kubosaki, K Hayashida, C Kawazu, M Murata, H Nishiyori, S Fukuda, J Kawai, CO Daub, DA Hume, H Suzuki, V Orl,:
"Tiny RNAs associated with transcription start sites in animals"
Nat Genet, 41:5, 572-578 (2009) - Carninci P, Sandelin A, Lenhard B, Katayama S, Shimokawa K, Ponjavic J, Semple CA, Taylor MS, Engström PG, Frith MC, Forrest AR, Alkema WB, Tan SL, Plessy C, Kodzius R, Ravasi T, Kasukawa T, Fukuda S, Kanamori-Katayama M, Kitazume Y, Kawaji H, Kai C, Naka,:
"Genome-wide analysis of mammalian promoter architecture and evolution"
Nat Genet, 38, 626-635 (2006) - Harukazu Suzuki, Alistair Forrest, Erik van Nimwegen, Carsten Daub, Piotr Balwierz, Katharine Irvine, Timo Lassmann, Timothy Ravasi, Yuki Hasegawa, Michiel De Hoon, Shintaro Katayama, Kate Schroder, Piero Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi,:
"Antisense transcription in the mammalian transcriptome"
Science, 309, 1564-1566 (2005) - Carninci P, Kasukawa T, Katayama S, Gough J, Frith MC, Maeda N, Oyama R, Ravasi T, Lenhard B, Wells C, Kodzius R, Shimokawa K, Bajic VB, Brenner SE, Batalov S, Forrest AR, Zavolan M, Davis MJ, Wilming LG, Aidinis V, Allen JE, Ambesi-Impiombato A, Apweiler,:
"The transcriptional landscape of the mammalian genome"
Science, 309, 1559-1563 (2005) - Okazaki Y, Furuno M, Kasukawa T, Adachi J, Bono H, Kondo S, Nikaido I, Osato N, Saito R, Suzuki H, Yamanaka I, Kiyosawa H, Yagi K, Tomaru Y, Hasegawa Y, Nogami A, Schönbach C, Gojobori T, Baldarelli R, Hill DP, Bult C, Hume DA, Quackenbush J, Schriml LM.:
"Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs"
Nature, 420, 563-573 (2002) - Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, M.:
"Functional annotation of a full-length mouse cDNA collection"
Nature, 409, 685-690 (2001)
Principal Investigator
- Jun KAWAI
- Project Director
Staff Scientist
- Carsten Oliver DAUB
- Deputy Project Director
LSA System Development Unit
Principal Investigator
- Jun KAWAI
- Unit Leader
- Masaaki FURUNO
- Senior Scientist
- Hiroshi TARUI
- Senior Scientist
- Riichiroh MANABE
- Senior Scientist
- Thierry SENGSTAG
- Senior Scientist
- Syunji YAMAMORI
- Senior Technical Scientist
- Kengo USUI
- Michihira TAGAMI
- Technical Scientist
- Naoko SUZUKI
- Technical Scientist
- Yumiko YAMAMOTO
- Technical Scientist
- Shigehiro YOSHIDA
- Technical Scientist
- Hiroo INABA
- Technical Scientist
- Shiro FUKUDA
- Technical Scientist
- Fumi HORI
- Technical Scientist
- Takahiro ARAKAWA
- Technical Scientist
Technical Assistant
- Kumi NAKAMURA
- Technical Staff I
- Tsugumi KAWASHIMA
- Technical Staff I
- Shohei NOMA
- Technical Staff I
- Takehiro HASHIMOTO
- Technical Staff I
- Mizuho SAKAI
- Technical Staff I
- Hiromi SANO
- Technical Staff I
- Kaoru KAIDA
- Technical Staff I
Omics Regulation Research Unit
Principal Investigator
- Masayoshi ITO
- Unit Leader
Omics Function Research Unit
Principal Investigator
- Jun KAWAI
- Unit Leader
Technical Assistant
- Jean-Etienne MORLIGHEM
- Technical Staff I
Genome Technology Practical Implementation Unit
Principal Investigator
- Sotaro UEMURA
- Unit Leader