LSA Bioinformatics Core Facility
The LSA Bioinformatics Core Facility collaborates strongly with the other group and team of the Omics Sciences Center (OSC) at RIKEN. In joint research projects, we develop and implement the Bioinformatics methods required for the analysis of the novel and original data arising from novel high throughput experimental methods developed within the OSC. We also cooperate with other research groups at RIKEN and outside of RIKEN as well as with a large number of international collaborators. The LSA Bioinformatics Core Facility is the core Bioinformatics group of the Functional Annotation of the Mammalian Genome (FANTOM) project.
Currently, 10 researchers and 10 technical scientists and scientific programmers are working in the LSA Bioinformatics Core Facility together with 3 system engineers taking care of the computational infrastructure. We frequently welcome visiting scientists and interns and we recently started to accept PhD students in collaborations with several national and international universities like The University of Tokyo, Keio University, Tokyo Medical and Dental University, and the Karolinska Institute.
- Functional Annotation of the Mammalian cDNA (FANTOM)
- Further develop the Bioinformatics aspects of the Cap Analysis of Gene Expression (CAGE) technology for Next Generation Sequencing technologies
- Find novel classes of functional non-coding RNA
- de Hoon, M.J., Taft, R.J., Hashimoto, T., Kanamori-Katayama, M., Kawaji, H., Kawano, M., Kishima, M., Lassmann, T., Faulkner, G.J., Mattick, J.S., Daub, C.O., Carninci, P., Kawai, J., Suzuki, H., Hayashizaki, Y.:
" Cross-mapping and the identification of editing sites in mature microRNAs in high-throughput sequencing libraries."
Genome Res Jan 5 (2010) - Arner, E., Hayashizaki, Y., Daub, C.O.:
" NGSView: an extensible open source editor for next-generation sequencing data."
Bioinformatics Jan 1;26(1):125-6 (2010) - Lassmann, T., Hayashizaki, Y., Daub, C.O.:
" TagDust--a program to eliminate artifacts from next generation sequencing data."
Bioinformatics Nov 1;25(21):2839-40 (2009) - Takahashi, Y., Forrest, A.R., Maeno, E., Hashimoto, T., Daub, CO., Yasuda, J.:
" MiR-107 and MiR-185 can induce cell cycle arrest in human non small cell lung cancer cell lines."
PLoS One Aug 18;4(8):e6677 (2009) - Balwierz, P.J., Carninci, P., Daub, C.O., Kawai, J., Hayashizaki, Y., Van Belle, W., Beisel, C., van Nimwegen, E.:
" Methods for analyzing deep sequencing expression data: constructing the human and mouse promoterome with deepCAGE data."
Genome Biol 10(7):R79 (2009) - Hashimoto, T., de Hoon, M.J., Grimmond, S.M., Daub, C.O., Hayashizaki, Y., Faulkner, G.J.:
" Probabilistic resolution of multi-mapping reads in massively parallel sequencing data using MuMRescueLite."
Bioinformatics 1;25(19):2613-4 (2009) - Kawaji, H., Hayashizaki, Y., Daub, C.O.:
" SDRF2GRAPH: a visualization tool of a spreadsheet-based description of experimental processes."
BMC Bioinformatics 7;10:133 (2009) - Taft, R.J., Glazov, E.A., Cloonan, N., Simons, C., Stephen, S., Faulkner, G.J., Lassmann, T., Forrest, A.R., Grimmond, S.M., Schroder, K., Irvine, K., Arakawa, T., Nakamura, M., Kubosaki, A., Hayashida, K., Kawazu, C., Murata, M., Nishiyori, H., Fukuda, S., Kawai, J., Daub, C.O., Hume, D.A., Suzuki, H., Orlando, V., Carninci, P., Hayashizaki, Y., Mattick, J.S.:
" Tiny RNAs associated with transcription start sites in animals."
Nat Genet 41(5):572-8 (2009) - Faulkner, G.J., Kimura, Y., Daub, C.O., Wani, S., Plessy, C., Irvine, K.M., Schroder, K., Cloonan, N., Steptoe, A.L., Lassmann, T., Waki, K., Hornig, N., Arakawa, T., Takahashi, H., Kawai, J., Forrest, A.R., Suzuki, H., Hayashizaki, Y., Hume, D.A., Orlando, V., Grimmond, S.M., Carninci, P.:
" The regulated retrotransposon transcriptome of mammalian cells."
Nat Genet 41(5):563-71 (2009) - Suzuki, H., Forrest, A.R., van Nimwegen, E., Daub, C.O., Balwierz, P.J., Irvine, K.M., Lassmann, T., Ravasi, T., Hasegawa, Y., de Hoon, M.J., Katayama, S., Schroder, K., Carninci, P., Tomaru, Y., Kanamori-Katayama, M., Kubosaki, A., Akalin, A., Ando, Y., Arner, E., Asada, M., Asahara, H., Bailey, T., Bajic, V.B., Bauer, D., Beckhouse, A.G., Bertin, N., Björkegren. J., Brombacher, F., Bulger, E., Chalk, A.M., Chiba, J., Cloonan, N., Dawe, A., Dostie, J., Engström, P.G., Essack, M., Faulkner, G.J., Fink, J.L., Fredman, D., Fujimori, K., Furuno, M., Gojobori, T., Gough, J., Grimmond, S.M., Gustafsson, M., Hashimoto, M., Hashimoto, T., Hatakeyama, M., Heinzel, S., Hide, W., Hofmann, O., Hörnquist, M., Huminiecki, L., Ikeo, K., Imamoto, N., Inoue, S., Inoue, Y., Ishihara, R., Iwayanagi, T., Jacobsen, A., Kaur, M., Kawaji, H., Kerr, M.C., Kimura, R., Kimura, S., Kimura, Y., Kitano, H., Koga, H., Kojima, T., Kondo, S., Konno, T., Krogh, A., Kruger, A., Kumar, A., Lenhard, B., Lennartsson, A., Lindow, M., Lizio, M., Macpherson, C., Maeda, N., Maher, C.A., Maqungo, M., Mar, J., Matigian, N.A., Matsuda, H., Mattick, J.S., Meier, S., Miyamoto, S., Miyamoto-Sato, E., Nakabayashi, K., Nakachi, Y., Nakano, M., Nygaard, S., Okayama, T., Okazaki, Y., Okuda-Yabukami, H., Orlando, V., Otomo, J., Pachkov, M., Petrovsky, N., Plessy, C., Quackenbush, J., Radovanovic, A., Rehli, M., Saito, R., Sandelin, A., Schmeier, S., Schönbach, C., Schwartz, A.S., Semple, C.A., Sera, M., Severin, J., Shirahige, K., Simons, C., St Laurent, G., Suzuki, M., Suzuki, T., Sweet, M.J., Taft, R.J., Takeda, S., Takenaka, Y., Tan, K., Taylor, M.S., Teasdale, R.D., Tegnér, J., Teichmann, S., Valen, E., Wahlestedt, C., Waki, K., Waterhouse, A., Wells, C.A., Winther, O., Wu, L., Yamaguchi, K., Yanagawa, H., Yasuda, J., Zavolan, M., Hume, D.A., Arakawa, T., Fukuda, S., Imamura, K., Kai, C., Kaiho, A., Kawashima, T., Kawazu, C., Kitazume, Y., Kojima, M., Miura, H., Murakami, K., Murata, M., Ninomiya, N., Nishiyori, H., Noma, S., Ogawa, C., Sano, T., Simon, C., Tagami, M., Takahashi, Y., Kawai, J., Hayashizaki, Y.:
"The transcriptional network that controls growth arrest and differentiation in a human myeloid leukemia cell line."
Nat Genet 41(5):553-62 (2009)
Principal Investigator
- Alistair FORREST
- Facility Director
Staff Scientist
- Timo LASSMANN
- Senior Scientist
- Jessica Michelle SEVERIN
- Senior Technical Scientist
- Hideya KAWAJI
- Erik Anders ARNER
- Research Scientist
- Nicolas BERTIN
- Research Scientist
- Michiel Jan Laurens DE HOON
- Research Scientist
- Alexander Maxwell BURROUGHS
- Research Scientist
- Akira HASEGAWA
- Technical Scientist
Student Trainee
- Morana VITEZIC
- International Program Associate
- Kazuhiro KAJIYAMA
- Junior Research Associate
Technical Assistant
- Marina LIZIO
- Technical Staff 1

