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Laboratory for Local Neuronal Circuits
Toshihiko HOSOYA
Laboratory Head
Toshihiko HOSOYA (Ph.D.)
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Research Areas

One of the major goals in neuroscience is to understand information processing in the neocortex. The neocortex contains hundreds of neuronal subtypes, and these neurons form highly complicated circuits. This complexity has been an obstacle to the analysis of neocortical function.

The Hosoya lab investigates the structure and function of local neuronal circuits in the neocortex using molecular genetic and neurophysiological methods. The lab is currently interested in the structural rules of circuits composed of specific neuronal subtypes, and decomposition of complicated circuits into small component circuits.

The lab's researches have showed that a major subtype of layer V pyramidal neurons forms columnar functional microstructures, and that these microcolumns show periodic spatial organization. By further identifying important local structures in the cortical circuit and investigating their function, the laboratory aims to contribute to the understanding of the basic mechanisms of information processing in the neocortex.

Research Subject

  1. Functional analysis of microcolumnns in neocortical layer V.
  2. Identification of novel microorganizations in the neoroctical circuit.

Related links

  1. RIKEN Brain Science Institute Website_Laboratories PageNew Window

RIKEN RESEARCH

May 29, 2009
Elucidating the brain's neural networkNew Window

List of Selected Publications

  1. Maruoka H, Kubota K, Kurokawa R, Tsuruno S and Hosoya T.:
    " Periodic organization of a major subtype of pyramidal neurons in neocortical layer V."
    The Journal Neuroscience, 31(50), 18522-18542 (2011)
  2. Oizumi M, Ishii T, Ishibashi K, Hosoya T and Okada M.:
    " Mismatched decoding in the brain."
    The Journal Neuroscience, 30(13), 4815-4826 (2010)
  3. Agetsuma M, Aizawa H, Aoki T, Nakayama R, Takahoko M, Goto M, Sassa T, Amo R, Shiraki T, Kawakami K, Hosoya T, Higashijima S and Okamoto H.:
    " The habenula is crucial for experience-dependent modification of fear responses in zebrafish."
    Nature Neuroscience, 13(11), 1354-1356 (2010)
  4. Lesica NA, Ishii T, Stanley GB and Hosoya T.:
    " Estimating receptive fields from responses to natural stimuli with asymmetric intensity distributions."
    PLoS ONE. 3(8), e3060 (2008).
  5. Kaneda M, Ishii T and Hosoya T.:
    " Pathway-dependent modulation by P2-purinoceptors in the mouse retina."
    Eur J Neurosci. 28(1), 128-36 (2008).
  6. Hosoya T, Baccus S.A and Meister M.:
    " Dynamic predictive coding by the retina."
    Nature, 436(7047), 1971-77 (2005).
  7. Akiyama Y, Hosoya T, Poole AM and Hotta Y.:
    " The gcm-motif: a novel DNA-binding motif conserved in Drosophila and mammals."
    Proc Natl Acad Sci USA, 93(25), 14912-6(1996)
  8. Hosoya T, Takizawa K, Nitta K and Hotta Y.:
    " Glial cells missing: a binary switch between neuronal and glial determination in Drosophila."
    Cell, 82(6), 1025-36 (1995).

Members

Principal Investigator

Toshihiko HOSOYA
Laboratory Head

Members

Hisato MARUOKA
Research Scientist
Shun TSURUNO
Research Scientist
Nao NAKAGAWA
Research Scientist
Kaori KISO
Research Associate
Mai SAEKI
Research Associate
Rumi KUROKAWA
Technical Staff I
Naomi MATSUMOTO
Technical Staff I
Miyuki KISHINO
Assistant
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