Laboratory for Cognitive Brain Mapping
Research Areas
| To reveal mechanisms of higher brain functions such as recognition and decision making, we are conducting experiments with non-human primates and functional MRI with a 4T system on normal human subjects. In the research with non-human primates, the animals are trained with various behavioral paradigms, and single-cell recordings are conducted from the prefrontal and inferotemporal association cortical areas during the task performance. We are focusing on the mechanisms of visual object recognition in the inferotemporal cortex and those of goal-directed behavior in the prefrontal cortex. To relate research results in human subjects with those in experimental animals, we are also making efforts to increase the spatial resolution of fMRI with human subjects. |  Laboratory Head Keiji TANAKA (Ph.D.)  |
Research Subjects
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List of Selected Publications
| (1) | Mansouri, F.A., Buckley, M.J., and Tanaka, K.: "Mnemonic function of lateral prefrontal cortex in conflict-induced behavioral adjustment." Science 318: 987-990 (2007) |
| (2) | Sun, P., Ueno, K., Waggoner, R. A., Gardner, J. L., Tanaka, K., and Cheng, K.: "A temporal frequency-dependent functional architecture in human V1 revealed by high-resolution fMRI." Nature Neurosci. 10, 1404-1406 (2007) |
| (3) | Matsumoto, M., Matsumoto, K., Abe, H., and Tanaka, K.: "Medial Prefrontal Cell Activity Signaling Prediction Errors of Action Values." Nature Neuroscience, 10, 647-656 (2007) |
| (4) | Lehky, S.R. and Tanaka, K.: "Enhancement of object representations in primate perirhinal cortex during a visual working memory task." J. Neurophysiology, 97, 1298-1310 (2007). |
| (5) | Mogami, T. and Tanaka, K.: "Reward association affects neuronal responses to visual stimuli in macaque temporal and perirhinal cortices." J. Neuroscience, 26, 6761-6770 (2006). |
| (6) | Mansouri, F., Matsumoto, K., and Tanaka, K.: "Prefrontal cell activities related to monkeys' success and failure in adapting to rule changes in a Wisconsin Card Sorting Test (WCST) analog." J. Neuroscience, 26, 2745-2756 (2006). |
| (7) | Wang, G., Obama, S., Yamashita, W., Sugihara, T., and Tanaka, K.: "View-invariant object recognition without experience of object rotations." Nature Neuroscience, 8, 1568-1575 (2005). |
| (8) | Gardner, J.L., Sun, P., Waggoner, R.A., Ueno, K., Tanaka, K., and Cheng, K.: "Contrast adaptation and representation in human early visual cortex." Neuron, 47, 1-14 (2005). |
| (9) | Matsumoto, K., Suzuki, W., and Tanaka, K.: "Neuronal correlates of goal-based motor selection in the prefrontal cortex." Science, 301, 229-232 (2003). |
| (10) | Cheng, K., Waggoner, R. A., and Tanaka, K.: "Human ocular dominance columns as revealed by high-field functional magnetic resonance imaging." Neuron, 32, 359-374 (2001). |