Semyanov Research Unit

Unit Leader
Alexey SEMYANOV (Ph.D.)
We use electrophysiological and imaging techniques to reveal the functions of extrasynaptic interactions in the brain. This involves studying release and uptake of extrasynaptic signalling molecules, their diffusion in the extracellular space, and localisation and properties of their receptors.
- Role of astrocytes in synaptic transmission and extrasynaptic signaling (Wu, Y-W)
- Tonic activation of extrasynaptic GABA receptors in neurons of GAD65 knockout animals (Song, I, Brenner T.)
- Functional role of cell compartment specific activation of extrasynaptic NMDA receptors (Wu, Y-W)
- Regulation of glutamate transporter function in astrocytes (Shih, P-Y)
- Scimemi, A., Semyanov, A., Sperk, G., Kullmann, DM., and Walker, MC.:
" Multiple and plastic receptors mediate tonic GABAA receptor currents in the hippocampus"
J.Neurosci., 25(44) (2005). - Semyanov, A., Walker, M.C., Kullmann, D.M., and Silver, R.A.:
" Tonically active GABAA receptors: modulating gain and maintaining the tone"
Trends in Neurosciences, 27 262-269 (2004). - Semyanov, A., Walker, M.C., and Kullmann, D.M.:
" GABA uptake regulates cortical excitability via cell type-specific tonic inhibition"
Nature Neurosci., 6 484-490 (2003). - Semyanov, A. and Kullmann, D.M.:
" Kainate receptor-dependent axonal depolarization and action potential initiation in interneurons"
Nature Neurosci., 4, 718-723 (2001). - Semyanov, A. and Kullmann, D.M.:
" Modulation of GABAergic signaling among interneurons by metabotropic glutamate receptors"
Neuron, 25, 663-672 (2000). - Semyanov, A.:
" Can diffuse extrasynaptic signaling form a guiding template"
Neurochem Int. 2008 Jan;52(1-2):31-3 - Rama S, Vetrivel L, and Semyanov A.:
" Second-harmonic generation voltage imaging at subcellular resolution in rat hippocampal slices"
J Biophotonics, 3(12), 784-90 (2010) - Wanaverbecq N, Semyanov A, Pavlov I, Walker MC and Kullmann DM.:
" Cholinergic Axons Modulate GABAergic Signaling among Hippocampal Interneurons via Postsynaptic 7 Nicotinic Receptors"
J.Neurosci. 2007 V.27(21):5683-5693 - Pavlov I, Savtchenko L, Kullmann DK, Semyanov A, Walker MC.:
" Outwardly rectifying tonically active GABAA receptors in pyramidal cells modulate neuronal offset, not gain"
J.Neurosci. 2009, 29(48):15341-15350 - Song I, Savtchenko L, and Semyanov A.:
" Tonic excitation or inhibition is set by GABA(A) conductance in hippocampal interneurons"
Nat Commun, 2, 376 (2011)
Principal Investigator
- Alexey SEMYANOV
- Unit Leader
Members
- Inseon SONG
- Research Scientist
- Evgenia MALININA
- Visiting Researcher
- Pei-Yu SHIH
- Research Associate
- Yu-Wei WU
- Research Associate
- Iuliia DEMBITCKAIA
- Research Associate
- Akiko ASHIKARI
- Assistant
- Leonid Petrovich SAVCHENKO
- Visiting Scientist
- Mikhail DRUZIN
- Visiting Scientist
- Victor KAZANTSEV
- Visiting Scientist
- Zeug Steffen ANDRE
- Visiting Scientist
- Wei-Shan LAI
- Part-time Staff