Manabe Initiative Research Unit
Research Areas
The present stage of modern synthetic chemistry is far from truly ideal one. In the truly ideal synthetic chemistry, complex molecules should be synthesized from simple starting materials in one step or at most several steps (with high atom efficiency). To realize the ideal synthesis, we must significantly reduce the number of steps in synthetic routes to target molecules. Total atom efficiency of the synthetic routes must also be improved to a great extent. The aim of our research is to develop catalysts that can achieve the ideal synthesis.
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 Initiative Research Scientist Kei MANABE (D. Phar.)  |
Research Subject
(1) Development of tailor-made-type catalysts(2) Development of catalytic pinpoint reactions (3) Synthesis of functional oligomers |
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List of Selected Publications
| (1) | Wang, J.-R. and Manabe, K.: "High Ortho Preference in Ni-Catalyzed Cross-Coupling of Halophenols with Alkyl Grignard Reagents." Org. Lett. 11, 741-744 (2009). |
| (2) | Ishikawa, S. and Manabe, K.: "Synthesis of Substituted Monohalobenzenes via Ortho-Selective Cross-Coupling of Dihalobenzenes with Electron-Donating Ortho-Directing Groups." Synthesis 3180-3182 (2008). |
| (3) | Manabe, K. and Ishikawa, S.: "Ortho-Selective Cross-Coupling of Fluorobenzenes with Grignard Reagents. Acceleration by Electron-Donating Ortho-Directing Groups." Synthesis 2645-2649 (2008). |
| (4) | Manabe, K. and Ishikawa, S.; "Oligoarenes as Molecular Backbones of Catalysts: Synthesis and Applications." Chem. Commun. 3829-3838 (2008). |
| (5) | Ishikawa, S. and Manabe, K.: "Highly Ortho-Selective Cross Coupling of Dichlorobenzene Derivatives with Grignard Reagents." Org. Lett. 9, 5593-5595 (2007). |
| (6) | Ishikawa, S. and Manabe, K.: "ortho-Selective Cross Coupling of Dibromophenols and Dibromoanilines with Grignard Reagents in the Presence of Palladium Catalysts Bearing Hydroxylated Oligoarene-type Phosphine." Chem. Lett. 36, 1304-1305 (2007). |
| (7) | Ishikawa, S. and Manabe, K.: "Oligoarene Strategy for Catalyst Development. Hydroxylated Oligoarene-type Phosphines for Palladium-catalyzed Cross Coupling." Chem. Lett. 36, 1302-1303 (2007). |
| (8) | Ishikawa, S. and Manabe, K.: "Synthetic Method for Multifunctionalized Oligoarenes Using Pinacol Esters of Hydroxyphenylboronic Acids." Chem. Commun. 2589-2591 (2006). |
| (9) | Shimizu, H. and Manabe, K.: "Negishi Coupling Strategy of a Repetitive Two-Step Method for Oligoarene Synthesis." Tetrahedron Lett. 47, 5927-5931 (2006). |
| (10) | Ishikawa, S. and Manabe, K.: "Repetitive Two-Step Method for Oligoarene Synthesis through Rapid Cross-Coupling of Hydroxyphenylboronic Acids and Anhydrides." Chem. Lett. 35, 164-165 (2006). |