Laboratories
Disease Glycomics Team
Naoyuki TANIGUCHI
Team Leader
Naoyuki TANIGUCHI (D.Med.Sci.)
mail

Research Areas

Most of membrane receptors such as growth factor receptors are glycoproteins but the study on the role of their glycans are very limited. Very recently we found that these glycans directly or indirectly play pivotal roles as intra- and internal cell signaling molecules under physiological and disease conditions and also involved in the gene expression. Our laboratory aims to explore the role of glycans in the development and differentiation under physiological conditions, and down-regulated signals in the life tyle-related diseases such as diabetes and up-regulated signals in cancer, angogenesis and neurodegenerative diseases such as Alzheimer diseases. We will also focus on basic research in order to develop biomarkers and therapeutics using glycans.

Research Subject

  1. Glycan signals in cancer and lung emphysema
  2. Develpemtn of Cancer Biomarker
  3. Role of glycans in Alzheimer's disease
  4. Analysis of nucleotide sugars
  5. Role of glycans in angiogenesis

Related links

  1. RIKEN Advanced Science Institute Website_Laboratories PageNew Window

Press release

October 21,2010
Researchers identify amyloid β precursor protein specific to brain vessel endothelial cells
March 02,2010
Vascular endothelial cells regulate angiopoiesis through sialic acid formation:

RIKEN RESEARCH

June 17, 2011
Exposing the potential of sugar chains for the diagnosis and treatment of disease
Research into cellular sugar chains is revealing a series of new properties and functions with potential application in the diagnosis and treatment of diseaseNew Window

List of Selected Publications

  1. Li W., Lu, Q., Pang, Y., Jin, J., Wang, H., Cao, H., Li, Z., Wang, X., Ma, B., Chi, Y., Wang, R., Kondo, A., Gu, J., and Taniguchi, N.:
    "Core Fucosylation of Heavy Chains Regulates Assembly and Intracellular Signaling of Precursor B Cell Receptors"
    J. Biol. Chem. 287, 2500-2508. (2012)
  2. Kizuka, Y., Kitazume, S., Yoshida, M., and Taniguchi, N.:
    "Brain-specific expression of N-acetylglucosaminyltransferase IX (GnT-IX) is regulated by epigenetic histone modifications"
    J. Biol. Chem. 286, 31875-31884.(2011)
  3. Shirato K, Nakajima K, Korekane H, Takamatsu S, Gao C, Angata T, Ohtsubo K, Taniguchi N.:
    "Hypoxic regulation of glycosylation via the N-acetylglucosamine cycle."
    J Clin Biochem Nutr. 2011 Jan;48(1):20-5.
  4. Takamatsu, S., Antonopoulos, A., Ohtsubo, K., Ditto, D., Chiba, Y., Le, DT., Morris, HR., Haslam, SM., Dell, A., Marth, JD., Taniguchi, N.:
    "Physiological and glycomic characterization of N-acetylglucosaminyltransferase-IVa and -IVb double deficient mice."
    Glycobiology, 2010, 20, 485-497
  5. Kitazume,S.,Imamaki,R.,Ogawa,K.,Komi,N.,Futakawa,S,.Kojima,S.,Hashimoto,Y.,Marth J.D.,Paulson,J.C.and Taniguchi,N.:
    "α2,6-Sialic Acid on Platelet Endothelial Cell Adhesion Molecule (PECAM) Regulates Its Homophilic Interactions and Downstream Antiapoptotic Signaling"
    J. Biol. Chem. 285, 6515-6521. (2010)
  6. Kitazume, S.,Tachida,Y., Kato, M., Yamaguchi,Y., Honda,T., Hashimoto,Y., Wada,Y., Saito,T.,Iwata,N., Saido, T and Taniguchi, N.:
    "Brain endothelial cells produce amyloid β from amyloid precursor protein 770 and preferentially secrete the O-glycosylated form"
    J. Biol. Chem. 285, 40097-40103.(2010)
  7. Nakajima, K,, Kitazume, S., Angata, T., Fujinawa, R., Ohtsubo, K., Miyoshi, E., and Taniguchi, N.:
    "Simultaneous determination of nucleotide sugars involved in glycosylation with ion-pair reversed -phase HPLC"
    Glycobiology 20, 865-871. (2010)
  8. Kitazume,S., Oka,R., Ogawa, K., Futakawa,S., Hagiwara, S., Takigawa, H., Kato, M., Kasahara, A., Miyoshi, E., Taniguchi, N and Hashimoto, Y.:
    "Molecular insights into β-galactoside α2,6-sialyltransferase secretion in vivo"
    Glycobiology 19, 479-487. (2009)
  9. Tachida, Y., Nakagawa, K., Saito, T., Saido, T.C., Honda, T, Saito, Y., Murayama, S., Endo, T., Sakaguchi, G.,Kato, A., Kitazume, S., and Hashimoto, Y.:
    "Interleukin-1β up-regulates TACE to enhance -cleavage of APP in neurons: resulting decrease in Aβproduction"
    J. Neurochem. 204, 1387-1393. (2008)
  10. Sugimoto, I.,Futakawa, S., Oka, R., Ogawa, K., Marth, J. D., Miyoshi, E., Taniguchi, N., Hashimoto, Y. and Kitazume, S.:
    "ST6Gal I cleavage by BACE1 enhances the sialylation of soluble glycoproteins : A novel regulatory mechanism for α2,6-sialylation"
    J. Biol. Chem. 282, 34896-34903 (2007)

Members

Principal Investigator

Naoyuki TANIGUCHI
Team Leader

Staff Scientist

Shinobu KITAZUME
Deputy Team Leader
Kazuaki OHTSUBO
Deputy Team Leader
Ayako KURIMOTO
ASI Research Scientist
Congxiao GAO
ASI Research Scientist
Hiroaki KOREKANE
ASI Research Scientist
Yuriko TACHIDA
ASI Technical Scientist

Postdoctoral Fellow

Kenji KANEKIYO
Postdoctoral Researcher
Satoshi KOBAYASHI
Postdoctoral Researcher
Yasuhiko KIZUKA
Postdoctoral Researcher

Student Trainee

Kyohei OKAHARA
Junior Research Associate

Technical Assistant

Emi ITO
Technical Staff I
Reiko FUJINAWA
Technical Staff I
Rie IMAMAKI
Technical Staff I
Fumi OTA
Technical Staff I
Keiichi YOSHIDA
Technical Staff II

Administrative Assistant

Izumi FUNAYAMA
Assistant
Izumi SUGASE
Assistant

Others

Palacpac Emmanuel SIOTA
Part-timer 1
Akemi SUZUKI
Part-timer 2
Kazuko OGAWA
Part-timer 2
Shiho KOBAYASHI
Part-timer 2
Keiko SATO
Part-timer 2