Disease Glycomics Team

Team Leader
Naoyuki TANIGUCHI (D.Med.Sci.)
Most of membrane receptors such as growth factor receptors are glycoproteins but the study on the role of their glycans are very limited. Very recently we found that these glycans directly or indirectly play pivotal roles as intra- and internal cell signaling molecules under physiological and disease conditions and also involved in the gene expression. Our laboratory aims to explore the role of glycans in the development and differentiation under physiological conditions, and down-regulated signals in the life tyle-related diseases such as diabetes and up-regulated signals in cancer, angogenesis and neurodegenerative diseases such as Alzheimer diseases. We will also focus on basic research in order to develop biomarkers and therapeutics using glycans.
- Glycan signals in cancer and lung emphysema
- Develpemtn of Cancer Biomarker
- Role of glycans in Alzheimer's disease
- Analysis of nucleotide sugars
- Role of glycans in angiogenesis
- October 21,2010
- Researchers identify amyloid β precursor protein specific to brain vessel endothelial cells
- March 02,2010
- Vascular endothelial cells regulate angiopoiesis through sialic acid formation:
- Li W., Lu, Q., Pang, Y., Jin, J., Wang, H., Cao, H., Li, Z., Wang, X., Ma, B., Chi, Y., Wang, R., Kondo, A., Gu, J., and Taniguchi, N.:
"Core Fucosylation of Heavy Chains Regulates Assembly and Intracellular Signaling of Precursor B Cell Receptors"
J. Biol. Chem. 287, 2500-2508. (2012) - Kizuka, Y., Kitazume, S., Yoshida, M., and Taniguchi, N.:
"Brain-specific expression of N-acetylglucosaminyltransferase IX (GnT-IX) is regulated by epigenetic histone modifications"
J. Biol. Chem. 286, 31875-31884.(2011) - Shirato K, Nakajima K, Korekane H, Takamatsu S, Gao C, Angata T, Ohtsubo K, Taniguchi N.:
"Hypoxic regulation of glycosylation via the N-acetylglucosamine cycle."
J Clin Biochem Nutr. 2011 Jan;48(1):20-5. - Takamatsu, S., Antonopoulos, A., Ohtsubo, K., Ditto, D., Chiba, Y., Le, DT., Morris, HR., Haslam, SM., Dell, A., Marth, JD., Taniguchi, N.:
"Physiological and glycomic characterization of N-acetylglucosaminyltransferase-IVa and -IVb double deficient mice."
Glycobiology, 2010, 20, 485-497 - Kitazume,S.,Imamaki,R.,Ogawa,K.,Komi,N.,Futakawa,S,.Kojima,S.,Hashimoto,Y.,Marth J.D.,Paulson,J.C.and Taniguchi,N.:
"α2,6-Sialic Acid on Platelet Endothelial Cell Adhesion Molecule (PECAM) Regulates Its Homophilic Interactions and Downstream Antiapoptotic Signaling"
J. Biol. Chem. 285, 6515-6521. (2010) - Kitazume, S.,Tachida,Y., Kato, M., Yamaguchi,Y., Honda,T., Hashimoto,Y., Wada,Y., Saito,T.,Iwata,N., Saido, T and Taniguchi, N.:
"Brain endothelial cells produce amyloid β from amyloid precursor protein 770 and preferentially secrete the O-glycosylated form"
J. Biol. Chem. 285, 40097-40103.(2010) - Nakajima, K,, Kitazume, S., Angata, T., Fujinawa, R., Ohtsubo, K., Miyoshi, E., and Taniguchi, N.:
"Simultaneous determination of nucleotide sugars involved in glycosylation with ion-pair reversed -phase HPLC"
Glycobiology 20, 865-871. (2010) - Kitazume,S., Oka,R., Ogawa, K., Futakawa,S., Hagiwara, S., Takigawa, H., Kato, M., Kasahara, A., Miyoshi, E., Taniguchi, N and Hashimoto, Y.:
"Molecular insights into β-galactoside α2,6-sialyltransferase secretion in vivo"
Glycobiology 19, 479-487. (2009) - Tachida, Y., Nakagawa, K., Saito, T., Saido, T.C., Honda, T, Saito, Y., Murayama, S., Endo, T., Sakaguchi, G.,Kato, A., Kitazume, S., and Hashimoto, Y.:
"Interleukin-1β up-regulates TACE to enhance -cleavage of APP in neurons: resulting decrease in Aβproduction"
J. Neurochem. 204, 1387-1393. (2008) - Sugimoto, I.,Futakawa, S., Oka, R., Ogawa, K., Marth, J. D., Miyoshi, E., Taniguchi, N., Hashimoto, Y. and Kitazume, S.:
"ST6Gal I cleavage by BACE1 enhances the sialylation of soluble glycoproteins : A novel regulatory mechanism for α2,6-sialylation"
J. Biol. Chem. 282, 34896-34903 (2007)
Principal Investigator
- Naoyuki TANIGUCHI
- Team Leader
Staff Scientist
- Shinobu KITAZUME
- Deputy Team Leader
- Kazuaki OHTSUBO
- Deputy Team Leader
- Ayako KURIMOTO
- ASI Research Scientist
- Congxiao GAO
- ASI Research Scientist
- Hiroaki KOREKANE
- ASI Research Scientist
- Yuriko TACHIDA
- ASI Technical Scientist
Postdoctoral Fellow
- Kenji KANEKIYO
- Postdoctoral Researcher
- Satoshi KOBAYASHI
- Postdoctoral Researcher
- Yasuhiko KIZUKA
- Postdoctoral Researcher
Student Trainee
- Kyohei OKAHARA
- Junior Research Associate
Technical Assistant
- Emi ITO
- Technical Staff I
- Reiko FUJINAWA
- Technical Staff I
- Rie IMAMAKI
- Technical Staff I
- Fumi OTA
- Technical Staff I
- Keiichi YOSHIDA
- Technical Staff II
Administrative Assistant
- Izumi FUNAYAMA
- Assistant
- Izumi SUGASE
- Assistant
Others
- Palacpac Emmanuel SIOTA
- Part-timer 1
- Akemi SUZUKI
- Part-timer 2
- Kazuko OGAWA
- Part-timer 2
- Shiho KOBAYASHI
- Part-timer 2
- Keiko SATO
- Part-timer 2