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Disease Glycomics Team
Naoyuki TANIGUCHI
Team Leader
Naoyuki TANIGUCHI (D.Med.Sci.)
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Research Areas

Most of membrane receptors such as growth factor receptors are glycoproteins but the study on the role of their glycans are very limited. Very recently we found that these glycans directly or indirectly play pivotal roles as intra- and internal cell signaling molecules under physiological and disease conditions and also involved in the gene expression. Our laboratory aims to explore the role of glycans in the development and differentiation under physiological conditions, and down-regulated signals in the life tyle-related diseases such as diabetes and up-regulated signals in cancer, angogenesis and neurodegenerative diseases such as Alzheimer diseases. We will also focus on basic research in order to develop biomarkers and therapeutics using glycans.

Research Subject

  1. Glycan signals in cancer and lung emphysema
  2. Develpemtn of Cancer Biomarker
  3. Role of glycans in Alzheimer's disease
  4. Analysis of nucleotide sugars
  5. Role of glycans in angiogenesis

Related links

  1. RIKEN Advanced Science Institute Website_Laboratories PageNew Window

Press release

October 21,2010
Researchers identify amyloid β precursor protein specific to brain vessel endothelial cells
March 02,2010
Vascular endothelial cells regulate angiopoiesis through sialic acid formation:

RIKEN RESEARCH

June 17, 2011
Exposing the potential of sugar chains for the diagnosis and treatment of disease
Research into cellular sugar chains is revealing a series of new properties and functions with potential application in the diagnosis and treatment of diseaseNew Window

List of Selected Publications

  1. Kitazume,S.,Imamaki,R.,Ogawa,K.,Komi,N.,Futakawa,S,.Kojima,S.,Hashimoto,Y.,Marth J.D.,Paulson,J.C.and Taniguchi,N,.:
    "α2,6-Sialic Acid on Platelet Endothelial Cell Adhesion Molecule (PECAM) Regulates Its Homophilic Interactions and Downstream Antiapoptotic Signaling"
    J. Biol. Chem. 285, 6515-6521. (2010)
  2. Kitazume, S.,Tachida,Y., Kato, M., Yamaguchi,Y., Honda,T., Hashimoto,Y., Wada,Y., Saito,T.,Iwata,N., Saido, T and Taniguchi, N.,:
    "Brain endothelial cells produce amyloid β from amyloid precursor protein 770 and preferentially secrete the O-glycosylated form"
    J. Biol. Chem. 285, 40097-40103.(2010)
  3. K. Nakajima, S. Kitazume, T. Angata, R. Fujinawa, E. Miyoshi, and N. Taniguchi,:
    "Simultaneous determination of nucleotide sugars involved in glycosylation with ion-pair reversed -phase HPLC"
    Glycobiology 20, 865-871. (2010)
  4. Kitazume,S., Oka,R., Ogawa, K., Futakawa,S., Hagiwara, S., Takigawa, H.,:
    "Kato, M., Kasahara, A., Miyoshi, E., Taniguchi, N and Hashimoto, Y Molecular insights into β-"
    galactoside α2,6-sialyltransferase secretion in vivo Glycobiology in press. (2009)
  5. Taniguchi,N.,:
    "Toward cancer biomarker discovery using the glycomics approach."
    Proteomics 8, 3205-3208.(2008)
  6. Tachida, Y., Nakagawa, K., Saito, T., Saido, T.C., Honda, T, Saito, Y., Murayama, S., Endo, T., Sakaguchi, G.,:
    "Kato, A., Kitazume, S., and Hashimoto, Y. Interleukin-1β up-regulates TACE to enhance -cleavage of"
    APP in neurons: resulting decrease in Aβproduction J. Neurochem. 204, 1387-1393. (2008)
  7. Taniguchi, N.,:
    "A sugar-coated switch for cellular growth and arrest."
    Nat. Chem. Biol. 3, 307-309 (2007).
  8. Sugimoto, I.,Futakawa, S., Oka, R., Ogawa, K., Marth, J. D., Miyoshi, E., Taniguchi, N., Hashimoto, Y. and Kitazume, S.,:
    "ST6Gal I cleavage by BACE1 enhances the sialylation of soluble glycoproteins : A novel regulatory mechanism for α2,6-sialylation"
    J. Biol. Chem. 282, 34896-34903 (2007)
  9. Taniguchi, N., Miyoshi, E., Gu, J., Honke, K., and Matsumoto, A.:
    "Decoding sugar functions by identifying target glycoproteins."
    Curr. Opin. Struct. Biol. 16, 561-566 (2006).
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