Molecular Probe Dynamics Laboratory

Team Leader
Yasuyoshi WATANABE
(M.D., Ph.D.)
Our team follows the dynamics of molecular probes developed in CMIS, and recruit the probes to translational research with the clinical research partners. We perform pharmacokinetics and pharmacodynamics (PK/PD) studies, and also could test the drug delivery system (DDS) in animals and humans. Our team also makes efforts to further develop highly elaborate quantitative molecular imaging (MI) methods, fusion MI, and next-generation MI techniques, as well as sophisticated MI database.
- Evaluation by molecular imaging for drug development on genetic diseases
- Pharmacodynamics/pharmacokinetics imaging
- Elaboration of molecular imaging tools and development of new-generation and fusion imaging methods for simultaneous multi-molecular imaging
- May 25, 2011
- Developmental changes in P-glycoprotein function in the blood-brain barrier of nonhuman primates: PET study with R-11C-verapamil and 11C-oseltamivir
- September 21, 2010
- World's largest oligosaccharide cluster reveals influence of molecular structure on metabolism
- September 01, 2010
- PET imaging reveals movement of drug-carrier molecules involved in bile-mediated excretion
- May 20, 2010
- Cancer recognition capability improved with technique to chemically inject glycan links into lymphocytes
- April 19, 2010
- Fluorescent labeling of living cells easily accomplished in only minutes using chemical reactions
- Yashio, K., Katayama, Y., Takashima, T., Ishiguro, N., Doi, H., Suzuki, M., Wada, Y., Tamai, I., and Watanabe, Y.:
"Synthesis of [11C]uric acid, using [11C]phosgene, as a possible biomarker in PET imaging for diagnosis of gout."
Bioorg. Med. Chem. Lett., 22(1): 115-119, 2012. - Ozawa, M., Takahashi, K., Akazawa, K., Takashima, T., Nagata, H., Doi, H., Hosoya, T., Wada, Y., Cui, Y.L., Kataoka, Y., and Watanabe, Y.:
"Positron emission tomography imaging of aromatase in gastric parietal cells using [11C]Vorozole."
J. Nucl. Med., 52(12): 1964-1969, 2011. - Takashima, T., Hashizume, Y., Katayama, Y., Murai, M., Wada, Y., Maeda, K., Sugiyama, Y., and Watanabe, Y.:
"The involvement of organic anion transporting polypeptide in the hepatic uptake of telmisartan in rats: PET studies with 11C telmisartan."
Mol. Pharm., 8(5): 1789-1798, 2011. - Takashima, T., Yokoyama, C., Mizuma, H., Yamanaka, H., Wada, Y., Onoe, K., Nagata, H., Tazawa, S., Doi, H., Takahashi, K., Morita, M., Kanai, M., Shibasaki, M., Kusuhara, H., Sugiyama, Y., Onoe, H., and Watanabe, Y.:
"Developmental changes in P-glycoprotein function in the blood-brain barrier of non-human primates: PET study with R-[11C] verapamil and [11C] oseltamivir."
J. Nucl. Med., 52(6): 950-957, 2011. - Takahashi, K., Yamagishi, G., Hiramatsu, T., Hosoya, A., Onoe, K., Doi, H., Nagata, H., Wada, Y., Onoe, H., Watanabe, Y., and Hosoya, T.:
"Practical synthesis of precursor of [N-methyl-(11)C]vorozole, an efficient PET tracer targeting aromatase in the brain."
Bioorg. Med. Chem., 19(4): 1464-1470, 2011. - Yamashita, S., Takashima, T., Kataoka, M., Oh, H., Sakuma, S., Takahashi, M., Suzuki, N., Hayashinaka, E., Wada, Y., Cui, Y., and Watanabe, Y.:
"PET imaging of the gastrointestinal absorption of orally administered drugs in conscious and anesthetized rats."
J. Nucl. Med., 52(2): 249-56, 2011. - Kuboyama, T., Nakamura, M., Yoshino, M., Cui, Y.L., Sako, T., Wada, Y., Imanishi, T., Obika, S., Watanabe, Y., Suzuki, M., and Doi, H.:
"Stoichiometry-focused 18F-labeling of alkyne-substituted oligodeoxynucleotides using azido([18f]fluoromethyl)benzenes by Cu-catalyzed Huisgen reation."
Bioorg. Med. Chem., 19(1): 249-255, 2011 - Takashima, T., Nagata, H., Nakae, T., Cui, Y., Wada, Y., Kitamura, S., Doi, H., Suzuki, M., Maeda, K., Kusuhara, H., Sugiyama, Y., and Watanabe, Y.:
"PET studies using 15R-[11C]TIC-Me for the evaluation of hepatobiliary transport."
J. Pharmacol. Exp. Ther., 335(2): 314-323, 2010. - Tanaka, K., Minami, K., Tahara, T., Fujii, Y., Siwu, E.R., Nozaki, S., Onoe, H., Yokoi, S., Koyama, K., Watanabe, Y., and Fukase, K.:
"Electrocyclization-based labeling allows efficient in vivo imaging of cellular trafficking."
Chem. Med. Chem., 5(6): 841-845, 2010. - Takashima-Hirano, M., Shukuri, M., Takashima, T., Goto, M., Wada, Y., Watanabe, Y., Onoe, H., Doi, H., and Suzuki, M.:
"General Method for the (11)C-Labeling of 2-Arylpropionic Acids and Their Esters: Construction of a PET Tracer Library for a Study of Biological Events Involved in COXs Expression."
Chemistry, 16(14):4250-4258, 2010.
Principal Investigator
- Yasuyoshi WATANABE
- Team Leader
Members
- Yasuhiro WADA
- Deputy Team Leader
- Yasuko MATSUMOTO
- William Ewan HUME
- Senior Scientist
- Yousuke KANAYAMA
- Research Scientist
- Satoshi NOZAKI
- Research Scientist
- Kayo TAKAHASHI
- Research Scientist
- Tadayuki TAKASHIMA
- Research Scientist
- Yasuko MATSUMOTO
- Research Scientist
- Hiroshi TOYODA
- Research Scientist
- Keiji YASHIO
- Research Scientist
- Kei MIZUNO
- Special Postdoctoral Researcher
- Hidefumi MUKAI
- Special Postdoctoral Researcher
- Takashi OKAUCHI
- Research Associate
- Ikuko NAKAMURA
- Junior Research Associate
- Emi HAYASHINAKA
- Technical Staff I
- Yuka NAKATANI
- Technical Staff I
- Kayo ONOE
- Technical Staff I
- Chinuyo SUMITA
- Technical Staff I
- Yumiko KATAYAMA
- Technical Staff I
- Maiko TAKAHASHI
- Technical Staff I
- Maki ZOUDA
- Technical Staff I
- Kanako TAJIMA
- Technical Staff I