Laboratories
Molecular Probe Dynamics Laboratory
Yasuyoshi WATANABE
Team Leader
Yasuyoshi WATANABE
(M.D., Ph.D.)
mail

Research Areas

Our team follows the dynamics of molecular probes developed in CMIS, and recruit the probes to translational research with the clinical research partners. We perform pharmacokinetics and pharmacodynamics (PK/PD) studies, and also could test the drug delivery system (DDS) in animals and humans. Our team also makes efforts to further develop highly elaborate quantitative molecular imaging (MI) methods, fusion MI, and next-generation MI techniques, as well as sophisticated MI database.

Research Subject

  1. Evaluation by molecular imaging for drug development on genetic diseases
  2. Pharmacodynamics/pharmacokinetics imaging
  3. Elaboration of molecular imaging tools and development of new-generation and fusion imaging methods for simultaneous multi-molecular imaging

Related links

  1. RIKEN Center for Molecular Imaging Science Website_Laboratories PageNew Window

Press release

May 25, 2011
Developmental changes in P-glycoprotein function in the blood-brain barrier of nonhuman primates: PET study with R-11C-verapamil and 11C-oseltamivir
September 21, 2010
World's largest oligosaccharide cluster reveals influence of molecular structure on metabolism
September 01, 2010
PET imaging reveals movement of drug-carrier molecules involved in bile-mediated excretion
May 20, 2010
Cancer recognition capability improved with technique to chemically inject glycan links into lymphocytes
April 19, 2010
Fluorescent labeling of living cells easily accomplished in only minutes using chemical reactions

RIKEN RESEARCH

November 26,2010
A clear view through trees
Large tree-like sugar clusters provide potential in vivo probes for cancer cells New Window
July 23,2010
Bright lights for live cells
Surface-selective fluorescent labeling enables cell tracking in the body while preserving initial cell function New Window

List of Selected Publications

  1. Yashio, K., Katayama, Y., Takashima, T., Ishiguro, N., Doi, H., Suzuki, M., Wada, Y., Tamai, I., and Watanabe, Y.:
    "Synthesis of [11C]uric acid, using [11C]phosgene, as a possible biomarker in PET imaging for diagnosis of gout."
    Bioorg. Med. Chem. Lett., 22(1): 115-119, 2012.
  2. Ozawa, M., Takahashi, K., Akazawa, K., Takashima, T., Nagata, H., Doi, H., Hosoya, T., Wada, Y., Cui, Y.L., Kataoka, Y., and Watanabe, Y.:
    "Positron emission tomography imaging of aromatase in gastric parietal cells using [11C]Vorozole."
    J. Nucl. Med., 52(12): 1964-1969, 2011.
  3. Takashima, T., Hashizume, Y., Katayama, Y., Murai, M., Wada, Y., Maeda, K., Sugiyama, Y., and Watanabe, Y.:
    "The involvement of organic anion transporting polypeptide in the hepatic uptake of telmisartan in rats: PET studies with 11C telmisartan."
    Mol. Pharm., 8(5): 1789-1798, 2011.
  4. Takashima, T., Yokoyama, C., Mizuma, H., Yamanaka, H., Wada, Y., Onoe, K., Nagata, H., Tazawa, S., Doi, H., Takahashi, K., Morita, M., Kanai, M., Shibasaki, M., Kusuhara, H., Sugiyama, Y., Onoe, H., and Watanabe, Y.:
    "Developmental changes in P-glycoprotein function in the blood-brain barrier of non-human primates: PET study with R-[11C] verapamil and [11C] oseltamivir."
    J. Nucl. Med., 52(6): 950-957, 2011.
  5. Takahashi, K., Yamagishi, G., Hiramatsu, T., Hosoya, A., Onoe, K., Doi, H., Nagata, H., Wada, Y., Onoe, H., Watanabe, Y., and Hosoya, T.:
    "Practical synthesis of precursor of [N-methyl-(11)C]vorozole, an efficient PET tracer targeting aromatase in the brain."
    Bioorg. Med. Chem., 19(4): 1464-1470, 2011.
  6. Yamashita, S., Takashima, T., Kataoka, M., Oh, H., Sakuma, S., Takahashi, M., Suzuki, N., Hayashinaka, E., Wada, Y., Cui, Y., and Watanabe, Y.:
    "PET imaging of the gastrointestinal absorption of orally administered drugs in conscious and anesthetized rats."
    J. Nucl. Med., 52(2): 249-56, 2011.
  7. Kuboyama, T., Nakamura, M., Yoshino, M., Cui, Y.L., Sako, T., Wada, Y., Imanishi, T., Obika, S., Watanabe, Y., Suzuki, M., and Doi, H.:
    "Stoichiometry-focused 18F-labeling of alkyne-substituted oligodeoxynucleotides using azido([18f]fluoromethyl)benzenes by Cu-catalyzed Huisgen reation."
    Bioorg. Med. Chem., 19(1): 249-255, 2011
  8. Takashima, T., Nagata, H., Nakae, T., Cui, Y., Wada, Y., Kitamura, S., Doi, H., Suzuki, M., Maeda, K., Kusuhara, H., Sugiyama, Y., and Watanabe, Y.:
    "PET studies using 15R-[11C]TIC-Me for the evaluation of hepatobiliary transport."
    J. Pharmacol. Exp. Ther., 335(2): 314-323, 2010.
  9. Tanaka, K., Minami, K., Tahara, T., Fujii, Y., Siwu, E.R., Nozaki, S., Onoe, H., Yokoi, S., Koyama, K., Watanabe, Y., and Fukase, K.:
    "Electrocyclization-based labeling allows efficient in vivo imaging of cellular trafficking."
    Chem. Med. Chem., 5(6): 841-845, 2010.
  10. Takashima-Hirano, M., Shukuri, M., Takashima, T., Goto, M., Wada, Y., Watanabe, Y., Onoe, H., Doi, H., and Suzuki, M.:
    "General Method for the (11)C-Labeling of 2-Arylpropionic Acids and Their Esters: Construction of a PET Tracer Library for a Study of Biological Events Involved in COXs Expression."
    Chemistry, 16(14):4250-4258, 2010.

Members

Principal Investigator

Yasuyoshi WATANABE
Team Leader

Members

Yasuhiro WADA
Deputy Team Leader
Yasuko MATSUMOTO
William Ewan HUME
Senior Scientist
Yousuke KANAYAMA
Research Scientist
Satoshi NOZAKI
Research Scientist
Kayo TAKAHASHI
Research Scientist
Tadayuki TAKASHIMA
Research Scientist
Yasuko MATSUMOTO
Research Scientist
Hiroshi TOYODA
Research Scientist
Keiji YASHIO
Research Scientist
Kei MIZUNO
Special Postdoctoral Researcher
Hidefumi MUKAI
Special Postdoctoral Researcher
Takashi OKAUCHI
Research Associate
Ikuko NAKAMURA
Junior Research Associate
Emi HAYASHINAKA
Technical Staff I
Yuka NAKATANI
Technical Staff I
Kayo ONOE
Technical Staff I
Chinuyo SUMITA
Technical Staff I
Yumiko KATAYAMA
Technical Staff I
Maiko TAKAHASHI
Technical Staff I
Maki ZOUDA
Technical Staff I
Kanako TAJIMA
Technical Staff I