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Multiple Molecular Imaging Research Laboratory
Shuichi ENOMOTO
Team Leader
Shuichi ENOMOTO (D.Phar.,Sci.)
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Research Areas

The aim of the Multiple Molecular Imaging Research Laboratory is engaged in research on molecular imaging and metals in biology. In order to achieve the better understandings of roles, functions and regulation of metals in biological systems, we developed the multitracer technology and the multiple molecular imaging systems which is using by semiconductor Compton telescope. The Multiple Molecular Imaging Research Laboratory performs following researches: (1) Developments of the multitracer technology by using accelerator facilities. (2) Application studies of the multitracer technology in the fields of chemistry, biology, medicine, pharmacy, nutrition, environment, agriculture, etc. (3) Developments of the Gamma Ray Emission Imaging as a tool for the multi-molecular imaging apparatus (4) Basic research for drug discovery for use the multi-molecular imaging. (5) Researches of biological and physiological function of bio-trace elements by using the new technology. (6) Bioinformatics challenges for new molecular imaging probes developments.

Research Subject

  1. Developments and application studies on the multitracer technology
  2. Developments of the Gamma Ray Emission Imaging as a tool for the multi-molecular imaging apparatus
  3. Basic research for drug discovery for use the molecular imaging
  4. Researches of biological and physiological function of bio-trace elements by using the new technology
  5. Bioinformatics challenges for new molecular imaging probes developments

Related links

  1. RIKEN Center for Molecular Imaging Science Website_Laboratories PageNew Window
  2. Individual Website Laboratory PageNew Window
  3. Department of Pharmaceutical Analytical Chemistry PageNew Window

Press release

July 03, 2008
Successful development of a new diagnostic apparatus enabling simultaneous imaging of several radioactive drugs in a single measurement using mice, for the first time in the world

RIKEN RESEARCH

December 19, 2008
Many tracers make light work
A new type of biological camera can trace several different molecules at once in a live animal New Window

List of Selected Publications

  1. Fukuchi T, Arai Y, Watanabe F, Motomura S, Takeda S, Kanayama Y, Haba H, Watanabe Y, and Enomoto S.:
    "A Digital Signal Processing Module for Ge Semiconductor Detectors"
    IEEE Transactions on Nuclear Science, (2011) in press
  2. Kamino S, Horio Y, Komeda S, Minoura K, Ichikawa H, Horigome J, Tatsumi A, Kaji S, Yamaguchi T, Usami Y, Hirota S, Enomoto S, and Fujita Y.:
    "A new class of rhodamine luminophores: design, syntheses and aggregation-induced emission enhancement"
    Chem. Commun., 46(47): 9013-9015, (2010)
  3. Hiromura M, Kanayama Y, Igarashi K, Haba H, and Enomoto S.:
    "Metabolic interaction of bittern and various trace elements in mice using multi-tracer technology and gamma-ray emission imaging system (GREI) as new modality for multiple molecular imaging"
    Bull. Soc. Sea Water Sci. 64, 196-201, (2010).
  4. Kanayama Y, Motomura S, and Enomoto S.:
    "Development of multiple molecular imaging method using semiconductor Compton camera"
    Bunseki 9, 496-502, (2009).
  5. Motomura S, Kanayama Y, Haba H, Watanabe Y, Enomoto S:
    "Multiple molecular simultaneous imaging in a live mouse using semiconductor Compton camera"
    J. Anal. At. Spectrom., 23, 1089-1092 (2008)
  6. Motomura S, Enomoto S, Haba H, Igarashi K, Gono Y, Yano Y:
    "Gamma-ray Compton imaging of multitracer in biological samples using strip germanium telescope"
    IEEE Transaction on Nuclear Science, 54, 710-717 (2007)
  7. Enomoto S, Motomura S:
    "Development of the multiple nuclides simultaneous imaging by using Ge Compton telescope"
    Isotope News, 4, 2-5, (2006)
  8. Haba H, Kaji D, Kanayama Y, Igarashi K, Enomoto S.:
    "Development of a gas-jet multitarget system for multitracer production"
    Radiochim. Acta, 93, 539-542 (2005).
  9. Kanayama Y, Tsuji T, Enomoto S, Amano R:
    "Multitracer screening: Brain delivery of trace elements by eight different administration methods"
    BioMetals. 18, 553-565 (2005).
  10. Enomoto S:
    "Development of Multitracer Technology and Application Studies on Biotrace Element Research"
    Biomed. Res. Trace Elem., 16, 233-240 (2005).

Members

Principal Investigator

Shuichi ENOMOTO
Team Leader

Members

Makoto HIROMURA
Deputy Team Leader
Shinichiro KAMINO
Research Scientist
Tomonori FUKUCHI
Research Scientist
Shinji MOTOMURA
Research Scientist
Masanari TANIGUCHI
Junior Research Associate
Keiko WATANABE
Technical Staff I
Mitsue HAGIHARA
Technical Staff II
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