Laboratories
Molecular Imaging Integration Unit
Kazuhiro TAKAHASHI
Unit Leader
Kazuhiro TAKAHASHI (Ph.D.)
mail

Research Areas

Our Unit supports the research and development of integrated techniques for molecular imaging such as the efficient production of noble radio-labeled probes, highly sensitive measurements of the metabolites of labeled probes and the effective analysis of images measured by PET and the other modalities. We are currently developing a new multipurpose automatic synthesizer module with sterile, disposable kits capable of performing a number of critical tasks under cGMP conditions. The principle design goal is to use disposable kits that meet regulatory purity requirements, in most of the production processes. In addition, the Unit's flexible programming system makes it an ideal system for routine productions of useful compounds such as [11C]acetate, [11C]methionine, and [18F]FLT

Research Subject

  1. research and development of production of radionuclides with clinical cyclotrons
  2. development of automated chemical modules for noble radio-labeled probes
  3. development of effective productions of radio-labeled probes.
  4. development of high sensitive measurements of the metabolites
  5. development of effective analysis of images by PET and other modalities

Related links

  1. RIKEN Center for Molecular Imaging Science Website_Laboratories PageNew Window

List of Selected Publications

  1. T. Yano, S. Tazawa, K Takahashi.:
    "GMP Validation for PET Radiopharmaceuticals in RIKEN CMIS -Part 1-"
    PHARM TECH JAPAN, 26 (7), 1095-1100, 2010.
  2. K. Takahashi, S. Tazawa, T. Yano.:
    "GMP Validation for PET Radiopharmaceuticals in RIKEN CMIS -Part 2-"
    PHARM TECH JAPAN, 26 (8), 1405-1409, 2010.
  3. S. Tazawa, K. Takahashi, T. Yano.:
    "GMP Validation for PET Radiopharmaceuticals in RIKEN CMIS -Part 3-"
    PHARM TECH JAPAN, 26 (10), 1883-1888, 2010.
  4. S. Tazawa, K. Hasegawa, K. Takahashi, T. Yano, Y. Watanabe.:
    "Current Practice of producing 64Cu-DOTA-Trastuzumab Injections RIKEN CMIS according to GMP for Investigational Products."
    PHARM TECH JAPAN, 27(4), 27-36, 2011.

Members

Principal Investigator

kazuhiro TAKAHASHI
Unit Leader

Members

Shusaku TAZAWA
Research Scientist
Kohki AKIYAMA
Research Scientist
Akiko TACHIBANA
Technical Staff I
Riyo ZOCHI
Technical Staff I
Yoko MORIMOTO
Technical Staff I