Functional Probe Research Laboratory
Team Leader
Hirotaka ONOE (Ph.D.)
In cooperation with several other organizations, both domestically and overseas, the Functional Probe Research Laboratory works in the fields of developments of a novel PET molecular probe which recognizes a specific biological molecule for molecular imaging, and studies in vivo biological functions using that. Using this technique, we are attempting to realize the regenerative medicine with ES cell, iPS cell and gene manipulation techniques using non-primate subjects, and also are studying the involvements of neuroinflammation in the neurodegenerative diseases and also mechanisms of plasticity after stroke and spinal cord injury.
- Establishment of molecular imaging for the various biological functions
- Functional evaluation of molecular probes using gene-manipulated and disease animal models
- Molecular imaging for regenerative medicine
- Role of neuroinflammation in the neurodegenerative diseases
- Plasticity of neural network after the stroke and spinal cord injury.
- January 29, 2013
- New research uncovers the neural mechanism underlying drug cravings
- May 25, 2011
- Developmental changes in P-glycoprotein function in the blood-brain barrier of nonhuman primates: PET study with R-11C-verapamil and 11C-oseltamivir
- May 20, 2010
- Cancer recognition capability improved with technique to chemically inject glycan links into lymphocytes
- April 19,2010
- Fluorescent labeling of living cells easily accomplished in only minutes using chemical reactions
- March 09,2010
- Labeling of antipyretic and analgesic drugs enables successful visualization inside the body
- November 16, 2007
- The National Institute for Physiological Sciences and the Japan Science and Technology Agency, in collaboration with RIKEN and Hamamatsu Photonics K.K.'s Central Research Laboratory, have learned that after one to three months of rehabilitation training consisting of repetitively picking things up, Japanese macaque monkeys that had lost movement in their fingertips due to spinal injury start to move their fingertips as they did before the injury. The research also pinpointed the changes that occur during this process in the area of the brain related to the recovery.
- September 30, 2011
- Imaging inflammation in the living brain
A molecular probe that targets a pro-inflammatory enzyme allows visualization of inflammation during brain injury in rats
- Nishimura Y, Onoe H, Morichika Y, Perfiliev S, Tsukada H, Isa T.:
"Time-dependent central compensatory mechanisms of finger dexterity after spinal cord injury. "
Science, 318(5853):1150-5, 2007. - Mizuma H, Shukuri M, Hayashi T, Watanabe Y, Onoe H.:
"Establishment of in vivo brain imaging method in conscious mice."
J Nucl Med. 51(7):1068-1075, 2010. - Kawasaki T, Ago Y, Yano K, Araki R, Washida Y, Onoe H, Chaki S, Nakazato A, Hashimoto H, Baba A, Takuma K, Matsuda T.:
"Increased binding of cortical and hippocampal group II metabotropic glutamate receptors in isolation-reared mice."
Neuropharmacology. 60(2-3):397-404, 2011. - Shukuri M, Takashima-Hirano M, Tokuda K, Takashima T, Matsumura K, Inoue O, Doi H, Suzuki M, Watanabe Y, Onoe H.:
"In vivo expression of cyclooxygenase-1 in activated microglia/macrophages during neuroinflammation visualized by PET with 11C-Ketoprofen-methyl ester."
J Nucl Med. 52(7):1094-101, 2011. - Nishimura Y, Onoe H, Onoe K, Morichika Y, Tsukada H, Isa T.:
"Neural substrates for the motivational regulation of motor recovery after spinal-cord injury."
PLoS ONE. 6(9):e24854. 2011. - Shimazawa M, Ito Y, Inokuchi Y, Yamanaka H, Nakanishi T, Hayashi T, Ji B, Higuchi M, Suhara T, Imamura K, Araie M, Watanabe Y, Onoe H, Hara H.:
"An Alteration in the Lateral Geniculate Nucleus of Experimental Glaucoma Monkeys: In vivo Positron Emission Tomography Imaging of Glial Activation."
PLoS One. 7(1):e30526, 2012. - Doi D, Morizane A, Kikuchi T, Onoe H, Hayashi T, Kawasaki T, Motono M, Sasai Y, Saiki H, Gomi M, Yoshikawa T, Hayashi H, Shinoyama M, Mohamed R, Suemori H, Miyamoto S, Takahashi J.:
"Prolonged Maturation Culture Favors a Reduction in the Tumorigenicity and the Dopaminergic Function of Human ESC-Derived Neural Cells in a Primate Model of Parkinson's Disease."
Stem Cells. 2012. (in press)
Principal Investigator
- Hirotaka ONOE
- Team Leader
Members
- Takuya HAYASHI
- Deputy Team Leader
- Tsuyoshi TAHARA
- Research Scientist
- Hiroshi MIZUMA
- Research Scientist
- Chihiro YOKOYAMA
- Research Scientist
- Miho SHUKURI
- Research Scientist
- Toshiyuki KAWASAKI
- Research Scientist
- Hajime YAMANAKA
- Research Associate
- Yukako HIRAO
- Technical Staff I
- Masahiro OHNO
- Technical Staff I
- Takayuki OSE
- Technical Staff I
- Chiho TAKEDA
- Technical Staff II
- Akihiro KAWASAKI
- Technical Staff II