Research Areas

One of the major challenges in current biology is system-level understanding of dynamic and complex biological phenomena. The laboratory for systems biology has specific aims at development of the systems-biological technologies to dissect dynamic and complex biological systems, that covering atomic-level to molecular-level, cellular/tissue-level and organism-level, and their application for system-level understanding of the dynamic and complex organism-level biological processes such as mammalian circadian rhythm and early embryogenesis.

Research Subject

1. Robustness of biological clock from the atomic level
2. The season-detection mechanism of biological calendar from the molecular level.
3. The hourglass mechanism of sleep from the cellular level
4. Development of the systems-biological technologies to dissect dynamic and complex organism-level biological systems

Related links

1. RIKEN Center for Developmental Biology Website_Laboratories Page
2. Individual Website Laboratory Page

RIKEN RESEARCH

March 25,2011

Keeping to time counter-intuitively
Experimental work proves the theory that a circadian body clock requires a delay to function properly

January 28,2011

Gearing-up for spring
Rapid activation of specific genes readies the mammalian body for seasonal change

July 24,2009

Day in and day out
Fluctuations in the levels of various molecules in the blood provide a reliable indicator of the body's internal clo

March 05,2009

Decoding the rhythm of life
Genomic studies have now provided enough understanding to design clock genes

January 16,2009

Setting the cellular clock
Synthetic genetic circuits enable researchers to uncover the mechanisms by which cells set their internal clocks

February 01,2008

How light can scramble time
Researchers solve the mystery of how biological clocks are disrupted