Laboratory for Organogenesis and Neurogenesis
Research Areas
| Vertebrate embryogenesis is a complicated process that involves a number of cell-cell interactions in emrbyonic tissues. This group in focusing on molecular mechnisms underlying cell-cell interaction (inductive process) in organogenesis of complex organs such as brain. Also, we attempt to establish scientific bases for therapeutic application of in vitro differentiation systems. |  Group Director Yoshiki SASAI (M. D., Ph. D.)  |
Research Subjects
| (1) | Molecular mechanisms of fine positional information controlling brain development |
| (2) | Molecular analysis on brain pattern formation by using ES cells |
| (3) | Selective in vitro differentiation of cells and tissues for therapeutic application |
List of Selected Publications
| (1) | Eiraku, M, Watanabe, K., Matsuo-Takasaki, M., Kawada, M., Yonemura, S., Matsumura, M., Wataya, T., Nishiyama, A., Muguruma, K., and Sasai, Y. "Self-Organized Formation of Polarized Cortical Tissues from ES cells and its Active Manipulation by Extrinsic Signals." Cell Stem Cell 3, 519-532 (2008). |
| (2) | Wataya, T., Ando, S., Muguruma, K., Ikeda, H., Watanabe, K., Eiraku, M., Kawada, M., Takahashi, J., Hashimoto, N., and Sasai, Y.: "Minimization of Exogenous Signals in ES Cell Culture Induces Rostral Hypothalamic Differentiation." Proc Natl Acd Sci USA 105, 11796-11801. (2008). |
| (3) | Inomata, H., Haraguchi, T., and Sasai, Y.: "Robust Stability of the Embryonic Dorsal Axial Pattern Requires ONT1, a Secreted Scaffold for Chordin Degradation." Cell 134, 854-865 (2008). |
| (4) | Sasai, N., Yakura, R,, Kamiya, D., Nakazawa, Y., and Sasai, Y.: "Ectodermal Factor Restricts Mesoderm Differentiation by Inhibiting p53." Cell 133, 878-890 (2008). |
| (5) | Ikeya, M., Nosaka, T., Fukushima, K., Kawada, M., Furuta, Y., Kitamura, T., and Sasai, Y.: "Twisted gastrulation mutation suppresses skeletal defect phenotypes in Crossveinless 2 mutant mice." Mech Dev. 125, 832-842 (2008). |
| (6) | Watanabe, K., Ueno, M., Kamiya, D., Nishiyama, A., Matsumura, M., Wataya, T., Takahashi, J.B., Nishikawa, S., Nishikawa, S.-i., Muguruma, K., and Sasai, Y.: "A ROCK inhibitor permits survival of dissociated human embryonic stem cells." Nature Biotechnology 25, 681 - 686 (2007) |
| (7) | Onai, T., Matsuo-Takasaki, M., Inomata, H., Aramaki, T., Matsumura, M., Yakura, R., Sasai, N., and Sasai, Y.: "XTsh3 is an essential enhancing factor of canonical Wnt signaling in Xenopus axial determination." EMBO J 26, 2350-2360.(2007) |
| (8) | Arakawa, A., Matsuo-Takasaki, M., Takai, A., Inomata, H., Matsumura, M., Ikeya, M., Takahashi, K., Miyachi, Y., Sasai, N., and Sasai, Y.: "The secreted EGF-Discoidin factor xDel1 is essential for dorsal development of the Xenopus embryo." Developmental Biology 306, 160-169 (2007) |
| (9) | Ikeya, M., Kawada, M., Kiyonari, H., Sasai, N., Nakao, K., Furuta, Y., and Sasai, Y.: "Essential Pro-BMP Roles of Crossveinless 2 in Mouse Organogenesis." Development 133, 4463-4473. (2006) |
| (10) | Ueno, M., Matsumura, M., Watanabe, K., Nakamura, T., Osakada, F., Takahashi, M., Kawasaki, H., Kinoshita, S., and Sasai, Y.: "Neural Conversion of Embryonic Stem Cells by an Inductive Activity on Human Amniotic Membrane Matrix." Proc. Natl. Acad. Sci. USA 103, 9554-9559 (2006) |