Laboratory for Organogenesis and Neurogenesis

Group Director
Yoshiki SASAI
(M.D., Ph.D.)
Vertebrate embryogenesis is a complicated process that involves a number of cell-cell interactions in emrbyonic tissues. This group in focusing on molecular mechnisms underlying cell-cell interaction (inductive process) in organogenesis of complex organs such as brain. Also, we attempt to establish scientific bases for therapeutic application of in vitro differentiation systems.
- Molecular mechanisms of fine positional information controlling brain development
- Molecular analysis on brain pattern formation by using ES cells
- Selective in vitro differentiation of cells and tissues for therapeutic application
- September 13,2010
- Death dance reveals secrets of apoptosis in dissociated human ES cells
- September 05, 2008
- Knowing when to stop: New stability factor controls robustness of the dorsal-ventral axis
- May 28,2007
- Laboratory for Organogenesis and Neurogenesis of CDB succeeded in massive cell generation and the production of cerebral neural cells according to the development of a unique protocol for culturing cells from human embryonic stem cells.
- November 05,2010
- Replacing faulty neurons
An effective method for generating cerebellar neurons could lead to new treatments for movement disorders
- Suga, H., Kadoshima, T., Minaguchi, M., Ohgushi, M., Soen, M.,Nakano, T., Takata, N., Wataya, T., Muguruma, K., Miyoshi, H., Yonemura, S., Oiso, Y. & Sasai, Y.:
"Self-formation of functional adeno-hypophysis in three-dimensional culture."
Nature 480, 57-62 (2011) - Eiraku, M., Takata, N., Ishibashi, H., Kawada, M., Sakakura, E., Okuda, S., Sekiguchi, K., Adachi, T. and Sasai, Y.:
"Self-organizing optic-cup morphogenesis in three-dimensional culture. "
Nature 472, 51-56 .(2011) - Kamiya, D., Banno, S., Sasai, N., Ohgushi, M., Watanabe, K., Kawada, M., Yakura, R., Jakt , L.M., Nishikawa, S. and Sasai. Y.:
"Intrinsic transition of ES cell differentiation into neural progenitors."
Nature 470, 503-509 (2011) - Aramaki, T., Sasai, N., Yakura, R., Sasai, Y.:
"Jiraiya attenuates BMP signaling by interfering with type II BMP receptors in neuroectodermal patterning."
Dev Cell 19, 547-561 (2010). - Muguruma, K., Nishiyama, A., Ono, Y., Miyawaki, H., Mizuhara, E., Hori, S., Kakizuka, A., Obata, K., Yanagawa, Y., Hirano, T., Sasai, Y.:
"Ontogeny-recapitulating generation and tissue integration of ES cell-derived Purkinje cells."
Nature Neuroscience 13, 1171-1181 (2010). - Ohgushi, M., Matsumura, M., Eiraku, M., Murakami, K., Aramaki, T., Nishiyama, A., Muguruma, K., Nakano, T., Suga, H., Ueno, M., Ishizaki, T., Suemori, H., Narumiya, S., Niwa, H. and Sasai, Y.:
"Molecular Pathway and Cell State Responsible for Dissociation-Induced Apoptosis in Human Embryonic Stem Cells."
Cell Stem Cell 7, 225-39 (2010) - Takai, A., Inomata, H., Arakawa, A., Yakura, R., Matsuo-Takasaki, M., Sasai, Y.:
"Anterior neural development requires Del1, a matrix-associated protein that attenuates canonical Wnt signaling via the Ror2 pathway."
Development 137, 3293-3302 (2010). - Eiraku, M, Watanabe, K., Matsuo-Takasaki, M., Kawada, M., Yonemura, S., Matsumura, M., Wataya, T., Nishiyama, A., Muguruma, K. and Sasai, Y.:
"Self-Organized Formation of Polarized Cortical Tissues from ES cells and its Active Manipulation by Extrinsic Signals."
Cell Stem Cell 3, 519-532 (2008). - Wataya, T., Ando, S., Muguruma, K., Ikeda, H., Watanabe, K., Eiraku, M., Kawada, M., Takahashi, J., Hashimoto, N. and Sasai, Y.:
"Minimization of Exogenous Signals in ES Cell Culture Induces Rostral Hypothalamic Differentiation."
Proc Natl Acd Sci USA 105, 11796-11801. (2008). - Inomata, H., Haraguchi, T. and Sasai, Y.:
"Robust Stability of the Embryonic Dorsal Axial Pattern Requires ONT1, a Secreted Scaffold for Chordin Degradation."
Cell 134, 854-865 (2008).
Principal Investigator
- Yoshiki SASAI
- Group Director
Members
- Hidehiko INOMATA
- Senior Scientist
- Keiko MUGURUMA
- Research Specialist
- Nozomu TAKATA
- Research Scientist
- Makoto NASU
- Research Scientist
- Hideya SAKAGUCHI
- Technical Staff II
- Ayaka NISHIYAMA
- Technical Staff II
- Masako KAWADA
- Technical Staff II
- Tomoko HARAGUCHI
- Technical Staff II
- Rieko YAKURA
- Technical Staff II
- Mika SOUEN
- Technical Staff II