Laboratory for Stem Cell Biology
Group Director
Shin-Ichi NISHIKAWA
(M.D., Ph.D.)
Stem cells are one of the attractive sources for tissue regeneration. Recent technical advance to induce pluripotent stem cells from adult human somatic cells further prompted the research for guided differentiation of stem cells into specific cell lineages which can contribute to organ regeneration. Our research goal is to understand the mechanism of cell differentiation from pluripotent stem cells such as ES cells or iPS cells and the way how 'tissue -specific' stem cells are miantained as quiescent but expanded and recruited for tissue repair when necessary. We will study the in vitro differentiation of ES and iPS cells into mesodermal- hematopoietic or endothelial-cells and endodermal cells to utilize pluripotent stem cells for regeneration. As a model for tissue-specific stem cell system we will focus on melanocyte stem cell system especially aiming for the in vitro recaptulation of stem cell quinscence, proliferation and differentiation processes.
- Guided differentiation of pluripotent stem cells into mesodermal and endodermal cells
- Factors required for the maintanance, proliferation and differentiation of stem cells
- Investigation of the epigenetic changes controlling differentiation, reprogramming and tumorgenesis
- Molecular mechanism of cell-cell interaction during lymphoid organogenesis
- Kataoka Hiroshi,Hayashi Misato,Nakagawa Reiko, Tanaka Yosuke, Izumi Naoki, Nishikawa Satomi, Jakt L Martin, Tarui Hiroshi, Nishikawa Shinichi.:
"Etv2/ER71 induces vascular mesoderm from Flk1+PDGFRα+ primitive mesoderm."
Blood 118,6975-6986, 2011 - Ban Hiroshi, Nishishita Naoki, Fusaki Noemi, Tabata Toshiaki, Saeki Koichi, Shikamura Masayuki, Takada Nozomi, Inoue Makoto, Hasegawa Mamoru, Kawamata Shin, Nishikawa Shinichi.:
"Efficient generation of transgene-free human induced pluripotent stem cells (iPSCs) by temperature-sensitive Sendai virus vectors"
PNAS 108, 14234-14239, 2011 - Fukushima Yoko, Okada Mitsuhiro, Kataoka Hiroshi, Hirashima Masanori, Yoshida Yutaka, Mann Fanny, Gomi Fumi, Nishida Kohji, Nishikawa Shinichi, Uemura Akiyoshi.:
"Sema3E-PlexinD1 signaling selectively suppresses disoriented angiogenesis in ischemic retinopathy in mice"
J Clin Inv, 121, 1974-1985, 2011 - Kubota Yasushi, Osawa Masatake, Lars Jakt Martin, Yoshikawa Kazuaki, Nishikawa Shinichi.:
"Necdin restricts proliferation of hematopoietic stem cells during hematopoietic regeneration"
Blood114:4383-4392, 2009 - Eilken Hanna Nishikawa Shinichi, Schroeder Timm.:
"Continuous single-cell imaging of blood generation from haemogenic endothelium"
Nature 457, 896-900, 2009 - Kinoshita Masaki, Era Takumi, Jakt L Martin, Nishikawa Shinichi.:
"The novel protein kinase Vlk is essential for stromal function of mesenchymal cells."
Development, 136(12), 2063-79, 2009 - Egawa Gyouhei, Osawa Masatake, Uemura Akiyoshi, Miyachi Yoshiki, Nishikawa Shinichi.:
"Transient expression of ephrin b2 in perinatal skin is required for maintenance of keratinocyte homeostasis"
J. Invst Dermatol, 129, 2386-2395, 2009 - Nishikawa Shinichi, Goldstein Robert A, Nierras Concepcion R.:
"The promise of human induced pluripotent stem cells for research and therapy"
Nature Rev Mol Cell Biol, 9, 725-729, 2008 - Takashima Yasuhiro, Era Takumi, Nakao Kazuki, Kondoh Saki, Kasuga Masato, Smith Austin, Nishikawa Shinichi.:
"Neuroepithelial Cells Supply an Initial Transient Wave of MSC Differentiation"
Cell, 129, 1377-1388, 2007 - Samokhvalov Igor M, Samokhvalova Natalia I, Nishikawa Shinichi.:
"Cell tracing shows the contribution of the yolk sac to adult haematopoiesis."
Nature, 446, 1056-1061, 2007
Principal Investigator
- Shinichi NISHIKAWA
- Group Director
Members
- Lars Martin JAKT
- Research Specialist
- Yosuke TANAKA
- Research Scientist
- YanFung WONG
- Research Scientist
- Guo DING
- Research Scientist
- Takao YAMADA
- Visiting Researcher
- Satomi NISHIKAWA
- Technical Staff I
- Satoko MORIWAKI
- Technical Staff I
- Naoko YOSHIOKA
- Technical Staff I
- Misato HAYASHI
- Technical Staff I
- Iori SATO
- Technical Staff I
- Shino HIRAHARA
- Technical Staff I
- Kumiko KOBAYASHI
- Technical Staff I