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Laboratory for Growth Control Signaling
Takashi NISHIMURA
Team Leader
Takashi NISHIMURA (Ph.D.)
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Research Areas

The processes of animal development, including organ size and body size, are genetically predetermined, but these processes are also influenced by environmental factors such as nutrition. Linking the nutrient sensory system to an endocrine signaling network allows organisms to control the timing of cell proliferation and differentiation during animal development. Our team's research aims to shed light on the molecular basis for growth control and developmental timing at the cellular and tissue/organ level using Drosophila as a model system.

Research Subject

  1. Regulatory mechanisms for cell proliferation during animal development
  2. Regulatory mechanisms for developmental timing
  3. Molecular mechanisms for nutrient sensing

Related links

  1. RIKEN Center for Developmental Biology Website_Laboratories PageNew Window

List of Selected Publications

  1. Okamoto, N., Nishimori, Y. & Nishimura, T.:
    "Conserved role for the Dachshud protein with Drosophila Pax6 homolog Eyeless in insulin expression."
    Proc. Natl. Acad. Sci. USA. 109: 2406-2411. (2012)
  2. Wirtz-Peitz, F., Nishimura, T. & Knoblich, J.A.:
    "Linking cell cycle to asymmetric divisions: Aurora-A phosphorylates the Par complex to regulate Numb localization."
    Cell. 135: 161-173. (2008)
  3. Nishimura, T. & Kaibuchi, K.:
    "Numb controls integrin endocytosis for directional cell migration with aPKC and PAR-3."
    Dev. Cell. 13: 15-28. (2007)
  4. Nishimura, T., Yamaguchi, T., Tokunaga, A., Hara, A., Hamaguchi, T., Kato, K., Iwamatsu, A., Okano, H. & Kaibuchi, K.:
    "Role of Numb in dendritic spine development with a Cdc42 GEF interserctin and EphB2."
    Mol. Biol. Cell. 17: 1273-1285. (2006)
  5. Nishimura, T., Yamaguchi, T., Kato, K., Yoshizawa, M., Nabeshima, Y., Ohno, S., Hoshino, M. & Kaibuchi, K.:
    "PAR-6-PAR-3 mediates Cdc42-induced Rac activation through the Rac GEFs STEF/Tiam1."
    Nat. Cell Biol. 7: 270-277. (2005)

Members

Principal Investigator

Takashi NISHIMURA
Team Leader

Members

Tomoka MURAI
Research Scientist
Naoki OKAMOTO
Special Postdoctoral Researcher
Rinna NAKAMORI
Technical Staff I
Yuki YAMAUCHI
Technical Staff II
Takayuki YAMADA
Technical Staff II
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