Electron Microscope Laboratory
Head,Electron Microscope Laboratory
Shigenobu YONEMURA (Ph.D.)
Various types of cells that constitute the body have their specific shapes to play their specific roles. It is an important basis to understand development of the whole body which elucidate the molecular mechanism of cellular morphogenesis. Although cytoskeletons such as actin filaments and microtubules are known to be major materials for morphogenesis, our knowledge about the regulatory mechanism for their construction/destruction is still fragmentary. Our laboratory aims at understanding the molecular mechanism of organization of cell-to-cell junctions and of dynamic cellular morphological changes at cytokinesis or wound closure movement, taking morphological approaches as well as molecular biological approaches. Regulatory mechanism of force generation within cells and how cells use mechanical signals for establishement of cell polarity and cell-to-cell junctions are our recent projects.
- Regulation of adherens junction remodellig by forces using alpha-catenin as a mechanotransducer.
- Molecular mechanism of perception of dead cells and signaling of wound closure in cell sheets.
- Role of force generated by myosin II on establishment of epithelial polarity.
- December 24, 2010
- Pulling it together
- Ikeya, M.. Fukushima, K.. Kawada, M., Onishi, S., Furuta, Y., Yonemura, S., Kitamura, T., Nosaka, T.,Sasai, Y.:
"Cv2, functioning as a pro-BMP factor via twisted gastrulation, is required for early development of nephron precursors. "
Dev Biol. 337:405-414 (2010) - Nojima, H., Rothhamel. S., Shimizu, T., Kim, C. H., Yonemura, S., Marlow, F. L., Hibi, M.:
"Syntabulin, a motor protein linker, controls dorsal determination. "
evelpoment. 137:923-933 (2010) - *Haruta, T., Warrior, R., Yonemura, S, Oda, H.:
"The proximal half of the Drosophila E-cadherin extracellular region is dispensable for many cadherin-dependent events but required for ventral furrow formation."
Genes Cells. 15:193-208 (2010) - Sokabe, T., Fukumi-Tominaga, T., Yonemura, S., Mizuno, A., Tominaga, M.:
"The TRPV4 channel contributes to intercellular junction formation in keratinocytes. "
J Biol Chem. 285:18749-18758 (2010) - *Yonemura, S., Wada, Y., Watanabe, T., Nagafuchi, A. and Shibata, M.:
"α-catenin as a tension transducer that induces adherens junction development. "
Nature Cell Biol. 12:533-542 (2010) - Tajiri, R., Misaki, K., Yonemura, S., and Hayashi, S.:
"Dynamic shape changes of ECM-producing cells drive morphogenesis of ball-and-socket joints in the fly leg."
Development. 137:2055-2063 (2010) - *Iida, A., Sakaguchi, K., Sato, K., Sakurai, H., Nishimura, D., Iwaki, A., Takeuchi, M., Kobayashi, M., Misaki, K., Yonemura, S., Kawahara, A., and Sehara-Fujisawa, A.:
"Metalloprotease-dependent onset of blood circulation in zebrafish. "
Curr. Biol. 20:1110-1116 (2010) - *Otani T, Oshima K, Onishi S, Takeda M, Shinmyozu K, Yonemura S, and Hayashi S.:
"Kke regulates cell elongation through recycling endosome shuttling."
Dev. Cell. 20: 219-232 (2011) - Yamamoto, M., Morita, R., Mizoguchi, T., Matsuo, H., Isoda, M., Ishitani, T., Chitnis, A. B., Matsumoto, K., Crump, G., Hozumi, K., Yonemura, S., Kawakami, K., and Itoh, M.:
"Mib-Jag1-Notch signaling regulates patterning and structural roles of the notochord by controlling cell-fate decisions. "
Development. 137: 2527-2537 (2010) - *Takeuchi, K., Nakano, Y., Kato, U., Kaneda, M., Aizu, M., Awano, W., Yonemura, S., Kiyonaka, S., Mori, Y., Yamamoto, D., and Umeda M.:
"Changes in temperature preferences and energy homeostasis in dystroglycan mutants."
Science. 323, 1740-1743 (2009)