Laboratory for Cell Adhesion and Tissue Patterning
Group Director
Masatoshi TAKEICHI (Ph.D.)
To understand how animal cells constitute the multicellular systems, we study the regulatory mechanisms of cell-cell adhesion, focusing on cadherin adhesion molecules and associated proteins, such as catenins. One of our interests along this line is to identify signaling mechanisms that regulate cell-cell contacts, and to determine their roles in morphogenetic cell rearrangement. We are expecting that the outcomes of these studies would also contribute to our understanding of how cancer cells become invasive and metastatic. Our another interest is to explore the mechanisms of how neurons recognize each other and establish synaptic connections, leading to the organization of complex neural networks. The potential roles of cadherins and other membrane-associated proteins in such neural developmental processes are being studied.
- Regulation of cell-cell adhesion by cadherins and catenins
- Mechanisms of abnormal cell adhesion in cancer cells
- Cell recognition mechanisms in interneuronal connections
- December 09, 2009
- Tracks to the junction: Microtubules tethered to zonula adherens
- April 25, 2008
- Shroom3 recruits ROCKs to the apical junction
- December 17, 2007
- A mystery of the cadherin-actin interaction resolved
- August 30, 2007
- Protocadherin in neural pathways
- March 28, 2007
- Tracing bloodlines: Cell tagging shows an extraembryonic source of hematopoietic cells.
- December 25, 2006
- Cadherins go with the flow
- Meng, W., and Takeichi, M.:
"Adherens Junction: Molecular architecture and regulation."
J.Cell Biol. in press (2010) - Nishimura, T., and Takeichi, M.:
"Remodeling of the adherens junctions during morphogenesis."
Curr. Top. Dev. Biol. 89, 33-54 (2009) - Ito, S., and Takeichi, M.:
"Dendrites of cerebellar granule cells correctly recognize their target axons for synaptogenesis in vitro."
Proc. Natl. Acad. Sci. USA 106, 12792-12797(2009) - Ishiuchi, T., Misaki, T., Yonemura, S., Takeichi, M., and Tanoue, T.:
"Mammalian Fat and Dachsous cadherins regulate apical membrane organization in the embryonic cerebral cortex."
J. Cell Biol. 185, 959-967 (2009) - Meng, W., Mushika, Y., Ichii, T., and Takeichi, M.:
"Anchorage of microtubule minus-ends to adherens junctions regulates epithelial cell-cell contacts."
Cell 135, 948-959 (2008) - Nakao, S., Platek, A., Hirano, S., and Takeichi, M.:
"Contact-dependent promotion of cell migration by the OL-protocadherin-Nap1 interaction."
J. Cell Biol. 182, 2 395-410 (2008) - Nishimura , T., and Takeichi, M.:
"Shroom3-mediated recruitment of Rho kinases to the apical cell junctions regulates epithelial and neuroepithelial planar remodeling."
Development 135, 1493-15028 (2008) - Abe, K., and Takeichi, M.:
"EPLIN mediates linkage of the cadherin-catenin complex to F-actin and stabilizes the circumferential actin belt."
Proc. Natl. Acad. Sci. USA, 105, 13-19 (2008) - Uemura, M., Nakao, S., Suzuki, S.T., Takeichi, M., and Hirano, S.:
"OL-protocadherin is essential for growth of striatal axons and thalamocortical projections."
Nature Neuroscience, 10, 1151-1159 (2007) - Ichii, T., and Takeichi, M.:
"p120-catenin regulates microtubule dynamics and cell migration in a cadherin-independent manner."
Genes to Cells 12, 827-839 (2007)