Laboratory for Cell Adhesion and Tissue Patterning
Group Director
Masatoshi TAKEICHI (Ph.D.)
To understand how animal cells constitute the multicellular systems, we study the regulatory mechanisms of cell-cell adhesion, focusing on cadherin adhesion molecules and associated proteins, such as catenins. One of our interests along this line is to identify signaling mechanisms that regulate cell-cell contacts, and to determine their roles in morphogenetic cell rearrangement. We are expecting that the outcomes of these studies would also contribute to our understanding of how cancer cells become invasive and metastatic. Our another interest is to explore the mechanisms of how neurons recognize each other and establish synaptic connections, leading to the organization of complex neural networks. The potential roles of cadherins and other membrane-associated proteins in such neural developmental processes are being studied.
- Regulation of morphogenesis by cadherins and catenins
- Mechanisms of abnormal cell adhesion in cancer cells
- Cell recognition mechanisms in interneuronal connections
- Microtubule dynamics and cellular architecture
- Taguchi, K., Ishiuchi, T., and Takeichi, M.:
"Mechanosensitive EPLIN-dependent remodeling of adherens junctions regulates epithelial reshaping."
J. Cell Biol. 194, 643-656 (2011) - Takeichi, M.:
"Self-organization of animal tissues: cadherin-mediated processes."
Dev. Cell 21,24-26 (2011) - Togashi, H., Kominami, K., Waseda, M., Komura, H., Miyoshi, J., Takeichi, M., and Takai, Y.:
"Nectins establish a checkerboard-like cellular pattern in the auditory epithelium. "
Science 333, 1144-1147 (2011) - Oda, H., and Takeichi, M.:
"Structural and functional diversity of cadherin at the adherens junction."
J. Cell Biol. 193, 1137-1146 (2011) - Ishiuchi, T., and Takeichi, M.:
"Willin and Par3 cooperatively regulate epithelial apical constriction through aPKC-mediated ROCK phosphorylation. "
Nature Cell Biol. 13, 860-866 (2011) - Sugawara, Y., Matsumura, T., Takegahara, Y., Jin, Y., Tsukasaki, Y., Takeichi, M., and Fujinaga, Y.:
"Botulinum hemagglutinin disrupts the intercellular epithelial barrier by directly binding E-cadherin."
J. Cell Biol. 189, 691-700. - Meng, W. and Takeichi, M.:
"Adherens Junction: Molecular architecture and regulation."
Cold Spring Harbor Laboratory Press 49-61 (2010) - Nishimura, T., and Takeichi, M.:
"Remodeling of the adherens junctions during morphogenesis."
Curr. Top. Dev. Biol. 89, 33-54 (2009) - Ito, S., and Takeichi, M.:
"Dendrites of cerebellar granule cells correctly recognize their target axons for synaptogenesis in vitro."
Proc. Natl. Acad. Sci. USA 106, 12792-12797(2009) - Ishiuchi, T., Misaki, T., Yonemura, S., Takeichi, M., and Tanoue, T.:
"Mammalian Fat and Dachsous cadherins regulate apical membrane organization in the embryonic cerebral cortex."
J. Cell Biol. 185, 959-967 (2009)
Principal Investigator
- Masatoshi TAKEICHI
- Group Director
Members
- Shoko ITO
- Research Scientist
- Vassil Stenkov VASSILEV
- Research Scientist
- Mika TOYA
- Research Scientist
- Anna Karolina PLATEK
- Research Scientist
- Shuichi HAYASHI
- Research Scientist
- Kyoko KUBOTA
- Research Scientist
- Shigenori NAGAE
- Research Associate
- Nobutoshi TANAKA
- Research Associate
- Miwako NOMURA
- Technical Staff II
- Hiroko SAITO
- Technical Staff II
- Saeko KOBAYASHI
- Technical Staff II
- Yoko INOUE
- Technical Staff II
- Sylvain Jean Victor HIVER
- Technical Staff II