Laboratories
Kibo In-cabin Research Team
Akihiko NAKANO
Team Leader
Akihiko NAKANO (D.Sci.)
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Research Areas

Our team aims at utilizing the Pressurized Vessel of the Japan Experimental Module "Kibo" which comprises the International Space Station. The Pressurized Vessel will be used for a wide variety of in-cabin biological/life science researches, including responses of higher animals and plants to microgravity and high-dose cosmic rays, reproduction of mammals, development of relevant microscopic systems, high-quality protein crystallization for structural biology, and brain research on spatial recognition of astronauts, which will be conducted in collaboration of research groups within and outside of RIKEN.

Research Subject

  1. A variety of biological experiments on orbit under microgravity and high-dose cosmic rays
  2. High-quality protein crystallization for structural biology
  3. Brain research on spatial recognition of astronauts

Related links

  1. RIKEN Advanced Science Institute Website_Laboratories PageNew Window

List of Selected Publications

  1. F. Yatagai, M. Honma, A. Ukai, K. Omori, H. Suzuki, T. Shimazu, A. Takahashi, T. Ohnishi, N. Dohmae, N. Ishioka.:
    "Preliminary results of space experiment: Implications for the effects of space radiation and microgravity on survival and mutation induction in human cells"
    Adv. Space Res. 49, 479-486 (2012)
  2. Tomohiro Uemura, Hyeran Kim, Chieko Saito, Kazuo Ebine, Takashi Ueda, Paul Schulze-Lefert, and Akihiko Nakano.:
    "Qa-SNAREs localized to the trans-Golgi network regulate multiple transport pathways and extracellular disease resistance in plants"
    Proc. Natl. Acad. Sci. U. S. A. 109:1784-1789 (2012)
  3. Chieko Saito, Tomohiro Uemura, Chie Awai, Motoki Tominaga, Kazuo Ebine, Jun Ito, Takashi Ueda, Hiroshi Abe, Miyo Terao Morita, Masao Tasaka, and Akihiko Nakano.:
    "The occurence of bulbs, a complex configuration of the vacuolar membrane, is affected by mutations vacuolar SNARE and phospholipase in Arabidopsis"
    Plant J. 68:64-73 (2011)
  4. Kazuo Ebine, Masaru Fujimoto, Yusuke Okatani, Tomoaki Nishiyama, Tatsuaki Goh, Emi Ito, Tomoko Dainobu, Aiko Nishitani, Tomohiro Uemura, Masa H. Sato, Hans Thordal-Christensen, Nobuhiro Tsutsumi, Akihiko Nakano, and Takashi Ueda.:
    "A membrane trafficking pathway regulated by the plant-specific RAB GTPase ARA6"
    Nat. Cell Biol. 13:853-859 (2011)
  5. Masaru Fujimoto, Shin-ichi Arimura, Takashi Ueda, Hideki Takanashi, Yoshikazu Hayashi, Akihiko Nakano, and Nobuhiro Tsutsumi.:
    "Arabidopsis dynamin-related proteins DRP2B and DRP1A participate together in clathrin-coated vesicle formation during endocytosis"
    Proc. Natl. Acad. Sci. U. S. A. 107:6094-6099 (2010)
  6. Hashiguchi, Y., Niihama, M., Takahashi, T., Saito, C., Nakano, A., Tasaka, M., and Morita, M.T.:
    "Loss-of-function mutations of retromer large subunits suppress the phenotype of zig mutant that lacks Qb-SNARE VTI11"
    Plant Cell 22, 159-172 (2010).
  7. Akeo Kadota, Noboru Yamada, Noriyuki Suetsugu, Mana Hirose, Chieko Saito, Keiko Shoda, Satoshi Ichikawa, Takatoshi Kagawa, Akihiko Nakano, and Masamitsu Wada.:
    "Short actin-based mechanism for light-directed chloroplast movement in Arabidopsis"
    Proc. Natl. Acad. Sci. U. S. A. 106:13106-13111 (2009)
  8. Morita, M.T., Saito, C., Nakano, A., and Tasaka, M.:
    "endodermal-amyloplast less 1 is a novel allele of SHORT-ROOT"
    Advances Space Res. 39, 1127-1133 (2007).
  9. Niihama, M., Uemura, T., Saito, C., Nakano, A., Sato, M.H., Tasaka, M., and Morita, M.T.:
    "Conversion of functional specificity in Qb-SNARE VTI1 homologues of Arabidopsis"
    Curr. Biol. 15, 555-560 (2005).
  10. Morita, M.T., Kato, T., Nagafusa, K., Saito, C., Ueda, T., Nakano, A., and Tasaka, M.:
    "Involvement of the vacuoles of the endodermis in the early process of shoot gravitropism in Arabidopsis"
    Plant Cell 14, 47-56 (2002).

Members

Principal Investigator

Akihiko NAKANO
Team Leader

Staff Scientist

Masaki YAMAMOTO
Masashi MIYANO
Yuji KAMIYA
Teruhiko WAKAYAMA
Atsushi IRIKI
Yoshitsugu SHIRO
Atsushi MIYAWAKI
Teruo HASHIMOTO
Research Scientist