Molecular Ligand Synthesis Research Team
Team Leader
Mikiko SODEOKA (D.Phar.)
This Team focuses on the development of novel types of ligand molecules, which can activate or inhibit the functions of their target proteins, based on synthetic organic chemistry. In particular, the ligand molecules, which interact with proteins involved in post-translational modification such as protein phosphorylation, glycosylation, methylation, acetylation will be designed and synthesized. We plan to design the ligand molecules based on the structure of physiological ligands and substrates of target molecules, the information on the ligand molecules found by Molecular Ligand Discovery Research Team and the structural information on target molecules found by Molecular Ligand Target Research Team. This Team also expects to contribute to identification of target molecules by optimizing ligand molecules and developing the probe molecules. In addition, we do innovate in the novel synthetic methodologies for synthesizing ligand molecules.
- Development of molecular ligands controlling protein modification
- Synthesis of molecular ligand derivatives for analysis of target proteins
- Development of synthetic methodology for molecular ligands
- Go Hirai, Ayako Tsuchiya, Yusuke Koyama, Yuko Otani, Kana Oonuma, Kosuke Dodo, Siro Simizu, Hiroyuki Osada, and Mikiko Sodeoka:
"Development of a Vaccinia H1-Related (VHR) Phosphatase Inhibitor with a NonAcidic Phosphate-Mimicking Core Structure"
ChemMedChem, in press - Eriko Iwasa, Yoshitaka Hamashima, Shinya Fujishiro, Eisuke Higuchi, Akihiro Ito, Minoru Yoshida, and Mikiko Sodeoka:
"Total Synthesis of (+)-Chaetocin and its Analogues: Their Histone Methyltransferase G9a Inhibitory Activity"
J. Am. Chem. Soc., 132, 4078-4079 (2010). - Atsushi Miyagawa, Kiichiro Totani, Ichiro Matsuo, and Yukishige Ito:
"Promiscuous activity of ER glucosidase II discovered through donor specificity analysis of UGGT"
Biochem. Biophys. Res. Commun., 403, 322-328 (2010). - Yue Qi Ye, Hiroyuki Koshino, Jun-ichi Onose, Kunie Yoshikawa, Naoki Abe, and Shunya Takahashi:
"Expeditious synthesis of vialinin B, an extremely potent inhibitor of TNF-α production"
Org. Lett. 11, 5074-5077 (2009). - Isao Fukuda, Akihiro Ito, Go Hirai, Shinichi Nishimura, Hisashi Kawasaki, Hisato Saitoh, Ken-ichi Kimura, Mikiko Sodeoka, Minoru Yoshida:
"Ginkgolic Acid Inhibits Protein SUMOylation by Blocking Formation of the E1-SUMO Intermediate"
Chemistry & Biology 16, 133-140 (2009). - Megumi Ohkubo, Go Hirai, Mikiko Sodeoka:
"Synthesis of the DFGH ring system of Type B Physalins: Highly Oxygenated, Cage-Shaped Molecules"
Angew. Chem. Int. Ed. 48, 3862-3866 (2009). - Taisuke Watanabe, Kiichiro Totani, Ichiro Matsuo, Jun-ichi Maruyama, Katsuhiko Kitamoto, and Yukishige Ito:
"Genetic analysis of glucosidase II β-subunit in trimming of high-mannose-type glycans"
Glycobiology 19, 834-840 (2009). - Yue Qi Ye, Hiroyuki Koshino, Jun-ichi Onose, Chiemi Negishi, Kunie Yoshikawa, Naoki Abe, and Shunya Takahashi:
"Structural Revision of Thelephantin G by Total Synthesis and the Inhibitory Activity against TNF-α Production"
J. Org. Chem. 74, 4642-4645 (2009).