Molecular Ligand Synthesis Research Team
Team Leader
Mikiko SODEOKA (D.Phar.)
This Team focuses on the development of novel types of ligand molecules, which can activate or inhibit the functions of their target proteins, based on synthetic organic chemistry. In particular, the ligand molecules, which interact with proteins involved in post-translational modification such as protein phosphorylation, glycosylation, methylation, acetylation will be designed and synthesized. We plan to design the ligand molecules based on the structure of physiological ligands and substrates of target molecules, the information on the ligand molecules found by Molecular Ligand Discovery Research Team and the structural information on target molecules found by Molecular Ligand Target Research Team. This Team also expects to contribute to identification of target molecules by optimizing ligand molecules and developing the probe molecules. In addition, we do innovate in the novel synthetic methodologies for synthesizing ligand molecules.
- Development of molecular ligands controlling protein modification
- Synthesis of molecular ligand derivatives for analysis of target proteins
- Development of synthetic methodology for molecular ligands
- Ayako Tsuchiya, Go Hirai, Yusuke Koyama, Kana Oonuma, Yuko Otani, Hiroyuki Osada, and Mikiko Sodeoka,:
"Dual-specificity Protein Phosphatase CDC25A/B Inhibitor Identified from a Focused Library with Non-electrophilic Enamine Core Structure"
ACS Med. Chem. Lett. in press - Akihito Ishiwata, Ayaka Sakurai, Yoshiyuki Nishimiya, Sakae Tsuda, and Yukishige Ito,:
"Synthetic study and structural analysis of the antifreeze agent xylomannan from Upis ceramboides"
J. Am. Chem. Soc., 133, 19524-19535 (2011). - Yuko Izuchi, Hiroyuki Koshino, Yayoi Hongo, Nobuhiro Kanomata, and Shunya Takahashi,:
"Synthesis and Structural Revision of Phomopsin B, a Novel Polyketide Carrying a 10-Membered Cyclic-Ether Ring"
Org. Lett. 13, 3360-3363 (2011) - Go Hirai, Ayako Tsuchiya, Yusuke Koyama, Yuko Otani, Kana Oonuma, Kosuke Dodo, Siro Simizu, Hiroyuki Osada, and Mikiko Sodeoka,:
"Development of a Vaccinia H1-Related (VHR) Phosphatase Inhibitor with a NonAcidic Phosphate-Mimicking Core Structure"
ChemMedChem 6, 617-622 (2011). - Yu Nakagawa, Takashi Doi, Yuichi Masuda, K. Tagegoshi, Yasuhiro Igarashi, and Yukishige Ito,:
"Mapping of the primary mannose binding site of Pradimicin A"
J. Am. Chem. Soc., 133, 17485-17493 (2011). - Shunya Takahashi, Yayoi Hongo, Yue Qi Ye, and Hiroyuki Koshino,:
"Simple and Efficient Synthesis of Highly Functionalized Cyclohexanones; Formal Total Synthesis of Ovalicin and Fumagillin"
Tetrahedron: Asymmetry 22, 703-707 (2011). - Eriko Iwasa, Yoshitaka Hamashima, Shinya Fujishiro, Eisuke Higuchi, Akihiro Ito, Minoru Yoshida, and Mikiko Sodeoka,:
"Total Synthesis of (+)-Chaetocin and its Analogues: Their Histone Methyltransferase G9a Inhibitory Activity"
J. Am. Chem. Soc., 132, 4078-4079 (2010).
Principal Investigator
- Mikiko SODEOKA
- Team Leader
Staff Scientist
- Yukishige ITO
- Hiroyuki KOSHINO
- Go HIRAI
- Senior Research Scientist
- Shun-ya TAKAHASHI
- Senior Research Scientist
- Takemichi NAKAMURA
- Senior Research Scientist