Molecular Ligand Synthesis Research Team

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Molecular Ligand Synthesis Research Team

Research Areas

This Team focuses on the development of novel types of ligand molecules, which can activate or inhibit the functions of their target proteins, based on synthetic organic chemistry. In particular, the ligand molecules, which interact with proteins involved in post-translational modification such as protein phosphorylation, glycosylation, methylation, acetylation will be designed and synthesized. We plan to design the ligand molecules based on the structure of physiological ligands and substrates of target molecules, the information on the ligand molecules found by Molecular Ligand Discovery Research Team and the structural information on target molecules found by Molecular Ligand Target Research Team. This Team also expects to contribute to identification of target molecules by optimizing ligand molecules and developing the probe molecules. In addition, we do innovate in the novel synthetic methodologies for synthesizing ligand molecules.

Team Leader
Mikiko SODEOKA (D.Phar.)

Research Subject

(1)	Development of molecular ligands controlling protein modification
(2)	Synthesis of molecular ligand derivatives for analysis of target proteins
(3)	Development of synthetic methodology for molecular ligands

List of Selected Publications

(1)	Fukuda, I., Ito, A., Hirai, G., Nishimura, S., Kawasaki, H., Saitoh, H., Kimura, K., Sodeoka, M., and Yoshida, M.: "Ginkgolic Acid Inhibits Protein SUMOylation by Blocking Formation of the E1-SUMO Intermediate." Chemistry & Biology 16, 133-140 (2009).
(2)	Watanabe, T., Hirai, G., Kato, M., Hashizume, D., Miyagi, T., and Sodeoka, M.: "Synthesis of CH2-Linked ƒ¿(2,3)Sialylgalactose Analogue: On the Stereoselectivity of the Key Ireland-Claisen Rearrangement." Org. Lett. 10, 4167-4160 (2008).
(3)	Totani, K., Ihara, Y., Matsuo, I., and Ito, Y.: "Effects of Macromolecular crowding on glycoprotein processing enzymes." J. Am. Chem. Soc. 130, 2101-2107 (2008).
(4)	Uchiyama, M., Kobayashi, Y., Furuyama, T., Nakamura, S., Kajihara, Y., Miyoshi, T., Sakamoto, T., Kondo, Y., and Morokuma, K.: "Generation and Suppression of 3-/4-Functionalized Benzynes Using Zinc Ate Base (TMP-Zn-ate): New Approaches to Multi-substituted Benzenes." J. Am. Chem. Soc. 130, 472-480 (2008).
(5)	Takahashi, S., Hongo, Y., Tsukagoshi, Y., and Koshino, H.: "Structural determination of montanacin D by total synthesis." Org. Lett. 10, 4223-4226 (2008).

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