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Seed Compounds Exploratory Unit for Drug Discovery Platform
Minoru YOSHIDA
Unit Leader
Minoru YOSHIDA (D.Agr.)
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Research Areas

In this year, we set up HTS facilities, expanded a compound library for HTS, and completed HTS for 5 targets. The HTS campaign generated many primary hits, and promising candidates of hits were identified after the evaluation by secondary screenings.

Research Subject

  1. High throughput screening using in vitro and cell-based assay systems
  2. High content screening based on cell morphological changes
  3. High throughput screening for compounds that recover yeast phenotypes induced by human genes

Related links

  1. RIKEN Advanced Science Institute Website_Laboratories PageNew Window

List of Selected Publications

  1. Yashiroda, Y., Okamoto, R., Hatsugai, K., Takemoto, Y., Goshima, N., Saito, T., Hamamoto, M., Sugimoto, Y., Osada, H., Seimiya, H., and Yoshida, M.:
    "A novel yeast cell-based screen identifies flavone as a tankyrase inhibitor."
    Biochem. Biophys. Res. Commun. 394, 569-573, (2010).

Members

Principal Investigator

Minoru YOSHIDA
Unit Leader

Staff Scientist

Tetsuo ONUKI
Deputy Unit Leader

Postdoctoral Fellow

Kousiki MINO
Contract Researcher
Norio KUDO
Contract Researcher
Masako ABE
Special Technical Staff

Technical Assistant

Reika OKAMOTO
Technical Staff I
Iku KUWAHARA
Technical Staff I
Mami YOSHIMURA
Technical Staff I
Takeshi SONODA
Technical Staff II
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