Molecular Ligand Biology Research Team
The Molecular Ligand Biology Research Team aims to provide unique screening systems and figure out novel biological principles establishing bases for new drug discovery. To this end, we study the regulation of transcription/translation, hormonal reaction, chromatin function, immune reaction, differentiation of stem cells, and organogenesis relating to protein modification as well as epigenetics. We investigate the effects of newly discovered and/or synthesized molecular ligands on biological functions described above utilizing cultured animal and plant cells as well as animal and plant models.
- Development of unique chemical screening systems
- Exploration of novel functions and quality control via post-translational modification of proteins
- Basic studies for establishing new diagnosis and therapy
- March 02,2010
- Vascular endothelial cells regulate angiopoiesis through sialic acid formation
- May 01, 2009
- Protein cross-linking leads to cell death, induces alcohol-related hepatic deficit: Discovery of new mechanism for hepatic cell death in liver damaged by alcohol
- Tatsukawa, H., Fukaya, Y., Frampton, G., Martinez-Fuentes, A., Suzuki, K., Kuo, T.-F., Nagatsuma, K., Shimokado, K., Okuno, M., Wu, J., lismaa, S., Matsuura, T., Tsukamoto, H., Zern, M. A., Graham, R. M., and Kojima, S.:
"Role of transglutaminase 2 in liver injury via crosslinking and silencing of transcription factor, Sp1."
Gastroenterology., 136: 1783-1795 (2009) - Tsuzuki, S., Wada, A., and Ito, Y.:
"Photo-immobilization of biological components on gold-coated chips for measurements using surface plasmon resonance (SPR) and a quartz crystal microbalance (QCM)"
Biotechnol. Bioeng. 102: 700-707 (2009) - Komatsu T., Kawaide H., Saito C., Yamagami A., Shimada S., Nakazawa M., Matsui M., Nakano A., Tsujimoto M., Natsume M., Abe H., Asami T., and Nakano T.:
"The chloroplast protein BPG2 functions in brassinosteroid-mediated post-transcriptional accumulation of chloroplast rRNA."
The Plant Journal., 61: 409-422 (2010) - Mukhopadhyay, B., Liu, J. Osei-Hyiaman, D., Godlewski, G., Mukhopadhyay, P., Wang, L., Jeong, W., Gao, B., Duester, G., Mackie, K., Kojima, S., and Kunos, G.:
"Transcriptional regulation of cannabinoid receptor-1 expression in the liver by retinoic acid acting via retinoic acid receptor-γ."
J. Biol. Chem. 285(25):19002-19011 (2010) - Furumai R , Uchida K, Komi Y, Yoneyama M, Ishigami K, Watanabe H, Kojima S, and Yoshida M.:
"Spliceostatin A blocks angiogenesis by inhibiting global gene expression including VEGF"
Cancer Science 101(11): 2483-2489 (2010) - Tatsukawa H, Sano T, Fukaya Y, Ishibashi N, Watanabe M, Okuno M, Moriwaki H and Kojima S.:
"Dual induction of caspase 3- and transglutaminase-dependent apoptosis by acyclic retinoid in hepatocellular carcinoma cells."
Mol Cancer. 10: 4 (11pages) (2011) - Y. Ogiso, K. Tsuneizumi, N. Masuda, M. Sato and T. Tabata.:
"Robustness of the Dpp morphogen activity gradient depends on negative feedback regulation by the inhibitory Smad, Dad."
Develop. Growth and Differ. 53(5) : 668-678 (2011) - A. Ohnishi, J. J. Hull, M. Kaji, K. Hashimoto, J. M. Lee, K. Tsuneizumi, T. Suzuki, N. Dohmae, and S. Matsumoto.:
"Hormone signaling linked to silkmoth sex pheromone biosynthesis involves Ca2+/calmodulin-dependent protein kinase II (CaMKII)-mediated phosphorylation of the insect PAT family protein Bombyx mori lipid storage droplet protein-1 (BmLSD1)"
J. Biol. Chem. 286(27) : 24101-24112 (2011) - E. Matsuo, T. Nagamine, S. Matsumoto and K. Tsuneizumi.:
"Drosophila GTPase Nucleostemin 2 changes cellular distribution during larval development and GTP-binding motif is essential for the nucleoplasmic localization."
Biosci. Biotechnol. Biochem. 75(8) : 1511-1515 (2011) - Kuo TF, Tatsukawa H, Matsuura T, Nagatsuma K, Hirose S and Kojima S.:
"Free fatty acids induce transglutaminase 2-dependent apoptosis in hepatocytes via ER stress-stimulated PERK pathways"
J Cell Physiol. 227: 1130-1137 (2012)
Principal Investigator
- Soichi KOJIMA
- Team Leader
Staff Scientist
- Yoshihiro ITO
- Takeshi NAKANO
- Senior Research Scientist
- Hiroshi ABE
- Senior Research Scientist
- Kotaro SAKATA
- Collaboration Research from Industry
Postdoctoral Fellow
- Mitsuko HARA
- Postdoctoral Researcher
- Akiko KIRITA
- Special Technical Staff
Student Trainee
- Xian-Yang QIN
- Junior Research Associate
- Eun-Seo LEE
- International Program Associate
- Yuka YAMAMOTO
- Student Trainee
- Nozomi SATOU
- Company-Sponsored Researcher
- Takahiro AIKAWA
- Company-Sponsored Researcher
- Eri MATSUMURA
- Company-Sponsored Researcher
Technical Assistant
- Akiko NAKAMURA
- Technical Staff I
Administrative Assistant
- Kimie TAJIMA
- Assistant
Visiting Research Staff
- Tomokazu MATSUURA
- Visiting Scientist
- Keisuke NAGATSUMA
- Visiting Scientist
- Hideki TATSUKAWA
- Visiting Scientist
- Rajan Shrestha SHRESTHA
- Visiting Technician
- Norio IGARASHI
- Visiting Technician
Others
- Yasuyo TAKAYAMA
- Part-timer2
- Yuta HATANO
- Part-timer3

