Laboratories
Molecular Ligand Biology Research Team
Soichi KOJIMA
Team Leader
Soichi KOJIMA (Ph.D.)
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Research Areas

The Molecular Ligand Biology Research Team aims to provide unique screening systems and figure out novel biological principles establishing bases for new drug discovery. To this end, we study the regulation of transcription/translation, hormonal reaction, chromatin function, immune reaction, differentiation of stem cells, and organogenesis relating to protein modification as well as epigenetics. We investigate the effects of newly discovered and/or synthesized molecular ligands on biological functions described above utilizing cultured animal and plant cells as well as animal and plant models.

Research Subject

  1. Development of unique chemical screening systems
  2. Exploration of novel functions and quality control via post-translational modification of proteins
  3. Basic studies for establishing new diagnosis and therapy

Related links

  1. RIKEN Advanced Science Institute Website_Laboratories PageNew Window
  2. Individual Website Laboratory PageNew Window

Press release

March 02,2010
Vascular endothelial cells regulate angiopoiesis through sialic acid formation
May 01, 2009
Protein cross-linking leads to cell death, induces alcohol-related hepatic deficit: Discovery of new mechanism for hepatic cell death in liver damaged by alcohol

List of Selected Publications

  1. Tatsukawa, H., Fukaya, Y., Frampton, G., Martinez-Fuentes, A., Suzuki, K., Kuo, T.-F., Nagatsuma, K., Shimokado, K., Okuno, M., Wu, J., lismaa, S., Matsuura, T., Tsukamoto, H., Zern, M. A., Graham, R. M., and Kojima, S.:
    "Role of transglutaminase 2 in liver injury via crosslinking and silencing of transcription factor, Sp1."
    Gastroenterology., 136: 1783-1795 (2009)
  2. Tsuzuki, S., Wada, A., and Ito, Y.:
    "Photo-immobilization of biological components on gold-coated chips for measurements using surface plasmon resonance (SPR) and a quartz crystal microbalance (QCM)"
    Biotechnol. Bioeng. 102: 700-707 (2009)
  3. Komatsu T., Kawaide H., Saito C., Yamagami A., Shimada S., Nakazawa M., Matsui M., Nakano A., Tsujimoto M., Natsume M., Abe H., Asami T., and Nakano T.:
    "The chloroplast protein BPG2 functions in brassinosteroid-mediated post-transcriptional accumulation of chloroplast rRNA."
    The Plant Journal., 61: 409-422 (2010)
  4. Mukhopadhyay, B., Liu, J. Osei-Hyiaman, D., Godlewski, G., Mukhopadhyay, P., Wang, L., Jeong, W., Gao, B., Duester, G., Mackie, K., Kojima, S., and Kunos, G.:
    "Transcriptional regulation of cannabinoid receptor-1 expression in the liver by retinoic acid acting via retinoic acid receptor-γ."
    J. Biol. Chem. 285(25):19002-19011 (2010)
  5. Furumai R , Uchida K, Komi Y, Yoneyama M, Ishigami K, Watanabe H, Kojima S, and Yoshida M.:
    "Spliceostatin A blocks angiogenesis by inhibiting global gene expression including VEGF"
    Cancer Science 101(11): 2483-2489 (2010)
  6. Tatsukawa H, Sano T, Fukaya Y, Ishibashi N, Watanabe M, Okuno M, Moriwaki H and Kojima S.:
    "Dual induction of caspase 3- and transglutaminase-dependent apoptosis by acyclic retinoid in hepatocellular carcinoma cells."
    Mol Cancer. 10: 4 (11pages) (2011)
  7. Y. Ogiso, K. Tsuneizumi, N. Masuda, M. Sato and T. Tabata.:
    "Robustness of the Dpp morphogen activity gradient depends on negative feedback regulation by the inhibitory Smad, Dad."
    Develop. Growth and Differ. 53(5) : 668-678 (2011)
  8. A. Ohnishi, J. J. Hull, M. Kaji, K. Hashimoto, J. M. Lee, K. Tsuneizumi, T. Suzuki, N. Dohmae, and S. Matsumoto.:
    "Hormone signaling linked to silkmoth sex pheromone biosynthesis involves Ca2+/calmodulin-dependent protein kinase II (CaMKII)-mediated phosphorylation of the insect PAT family protein Bombyx mori lipid storage droplet protein-1 (BmLSD1)"
    J. Biol. Chem. 286(27) : 24101-24112 (2011)
  9. E. Matsuo, T. Nagamine, S. Matsumoto and K. Tsuneizumi.:
    "Drosophila GTPase Nucleostemin 2 changes cellular distribution during larval development and GTP-binding motif is essential for the nucleoplasmic localization."
    Biosci. Biotechnol. Biochem. 75(8) : 1511-1515 (2011)
  10. Kuo TF, Tatsukawa H, Matsuura T, Nagatsuma K, Hirose S and Kojima S.:
    "Free fatty acids induce transglutaminase 2-dependent apoptosis in hepatocytes via ER stress-stimulated PERK pathways"
    J Cell Physiol. 227: 1130-1137 (2012)

Members

Principal Investigator

Soichi KOJIMA
Team Leader

Staff Scientist

Yoshihiro ITO
Takeshi NAKANO
Senior Research Scientist
Hiroshi ABE
Senior Research Scientist
Kotaro SAKATA
Collaboration Research from Industry

Postdoctoral Fellow

Mitsuko HARA
Postdoctoral Researcher
Akiko KIRITA
Special Technical Staff

Student Trainee

Xian-Yang QIN
Junior Research Associate
Eun-Seo LEE
International Program Associate
Yuka YAMAMOTO
Student Trainee
Nozomi SATOU
Company-Sponsored Researcher
Takahiro AIKAWA
Company-Sponsored Researcher
Eri MATSUMURA
Company-Sponsored Researcher

Technical Assistant

Akiko NAKAMURA
Technical Staff I

Administrative Assistant

Kimie TAJIMA
Assistant

Visiting Research Staff

Tomokazu MATSUURA
Visiting Scientist
Keisuke NAGATSUMA
Visiting Scientist
Hideki TATSUKAWA
Visiting Scientist
Rajan Shrestha SHRESTHA
Visiting Technician
Norio IGARASHI
Visiting Technician

Others

Yasuyo TAKAYAMA
Part-timer2
Yuta HATANO
Part-timer3