Team Leader
Naoyuki TANIGUCHI (D.Med.Sci.)

Research Areas

We promote interdisciplinary research projects to study glycan-related cancers and infectious diseases through multiple approaches combining glycobiology, chemical biology, structural biology and bioinformatics. Intense attentions are paid to glycan structures which are closely related to cancer metastasis and progression. We aim to develop inhibitors for cancer-related glycosyltransferases. In addition, we analyze the binding mode of antibodies or lectins toward glycan-based cancer antigens. Structural information obtained will be used for exploiting the bioprobes specialized for the diagnosis of various cancers. Furthermore, we establish a basis for the development of therapeutics for COPD by understanding the relationship between glycan and the pathogenesis.

Research Subject

1. Screening and development of specific inhibitors for cancer-related glycosyltransferases
2. Development of bioprobes for the detection of cancer-related glycans.
3. Understanding the molecular mechanism of COPD and its application to the development of therapeutics.

Related links

1. RIKEN Advanced Science Institute Website_Laboratories Page