Research Areas

In collaboration with a group of Max Planck Institute (MPI) of Molecular Physiology (group of Prof. Herbert Waldmann), we study the cell cycle control through the identification of small molecule inhibitors of the proteins that have an important role for the progression of cell division. We propose the collaboration of these two groups by taking the merits of both different approaches by frequently exchanging materials, technologies and information. For example, after sending compounds of RIKEN NPDepo chemical library to MPI, the MPI group will screen for compounds that arrest cell division with interesting phenotypes. Then we will analyze the mechanism of action of the compounds by identifying the target proteins of the compounds. In the opposite way, MPI group will provide their compounds for the screening by the high throughput system of us. The isolated interesting compounds will be deeply analyzed by the MPI cell biology group.

Research Subject

1. High contents screening for small compounds with effects on cell cycle progression and analyses of their mechanism of action
2. Screening and analyses of small compounds with effects on cell cycle progression using chemical array

Related links

1. RIKEN Advanced Science Institute Website_Laboratories Page