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Research Group for Lipid Dynamics
Research Areas
Lipids are emerging as the last target of post-genome era. Accumulating evidence indicates the importance of lipids in most of the biological phenomena. However, their study has been hampered by the lack of appropriate techniques. Taking advantage of the outstanding scientists working in physics to biology field at RIKEN, we are developing a new and challenging approach to apprehend lipid science through an extensive interdisciplinary collaboration.
 

Toshihide KOBAYASHI
Group Head
Toshihide KOBAYASHI (Ph.D.)
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Research Subject
(1) Research for Imaging Lipids
(2) Research for Lipid Function
(3) Research for Molecular Dynamics of Lipids
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List of Selected Publications
(1) Matsunaga, S., Matsunaga, T., Iwamoto, K., Yamada, T., Shibayama, M., Kawai, M., and Kobayashi, T.:
"Visualization of Phospholipid Particle Fusion Induced by Duramycin."
Langmuir in press (2009).
(2) Kohyama-Koganeya, A., Kim, YJ., Miura, M., and Hirabayashi, Y.:
"A Drosophila orphan G protein-coupled receptor BOSS functions as a glucose-responding receptor: loss of boss causes abnormal energy metabolism."
Proc. Natl. Acad. Sci. U S A. 105, 15328-33 (2008).
(3) Takahashi, M., Murate, M., Fukuda, M., Sato, SB., Ohta, A., and Kobayashi, T.:
"Cholesterol controls lipid endocytosis through Rab11."
Mol. Biol. Cell 18, 2667-2677 (2007).
(4) Hayakawa, T., Makino, A., Murate, M., Sugimoto, I., Hashimoto, Y., Takahashi, H., Ito, K., Fujisawa, T., Matsuo, H., and Kobayashi, T.:
"pH-dependent formation of membranous cytoplasmic body-like structure of ganglioside GM1/bis(monoacylglycero)phosphate mixed membranes."
Biophys. J. 92, L13-16 (2007).
(5) Iwamoto, K., Hayakawa, T., Murate, M., Makino, A., Ito, K., Fujisawa, T., and Kobayashi, T.:
"Curvature-dependent recognition of ethanolamine phospholipids by duramycin and cinnamycin."
Biophys. J. 93, 1608-1619 (2007)