Hydrated Protein Structure Research Team
Research Areas
We analyze the accurate hydrated protein structures including water molecules using high resolution crystallography. There are three classes of water molecules in protein structure;
(1) water molecule(s) to exert(s) the protein function. (2) Water molecules are part of the protein structure and (3) Waters as the environments of the protein structure and function. These waters are part of the crystal structure or dynamically hydration of protein.
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Research Subject
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List of Selected Publications
| (1) | Nishibori, E., Nakamura, T., Arimoto, M., Aoyagi, S., Ago, H., Miyano, M., Ebisuzaki, T., and Sakata, M.: "Application of maximum-entropy maps in the accurate refinement of a putative acylphosphatase using 1.3 Å X-ray diffraction data." Acta Crystal. D64:237-247 (2008). |
| (2) | Shimamura, T., Hiraki, K., Takahashi, N., Hori, T., Ago, H., Masuda, K., Takio, K., Ishiguro, M., and Miyano, M.: "Crystal structure of squid rhodopsin with intracellularly extended cytoplasmic region. J. Biol. Chem." 283:17753-17756 (2008). |
| (3) | Ago, H., Kanaoka, Y., Irikura, D., Lam, B.K., Shimamura, T., Austen, K.F., and Miyano, M.: "Crystal structure of a human membrane protein involved in cysteinyl leukotriene.biosynthesis." Nature. 448:609-612 (2007). |
| (4) | Ishijima, J., Nagasaki, N., Maeshima, M., and Miyano, M.: "RVCaB, a calcium-binding protein in radish vacuoles, is predominantly an unstructured protein with a polyproline type II helix." J. Biochem. 142: 201-211 (2007) |
| (5) | Kurahashi Y, Sugahara M, Ago H, Aoyama S, Takahashi N, Takio K, Katsukawa M, Yamamoto S, and Miyano M.: "Crystallization and preliminary diffraction studies of prostaglandin E2-specific monoclonal antibody Fab fragment in the ligand complex." Acta Crystallogr F 64:1027-1030 (2008). |